Regulation of human beta cell mass

• Project/Area Number: 15K09399
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Keio University
• Principal Investigator: Saisho Yoshifumi 慶應義塾大学, 医学部(信濃町), 講師 (90327510)
• Co-Investigator(Renkei-kenkyūsha): YAMADA Taketo 慶應義塾大学, 医学部, 講師 (60230463) ; SATO Seiji 慶應義塾大学, 医学部, 助教 (90528762) ; INAISHI Jun 慶應義塾大学, 医学部, 助教 (60724565) ; MURAKAMI Rie 慶應義塾大学, 医学部, 助教 (40645719) ; KITAGO Minoru 慶應義塾大学, 医学部, 講師 (70296599)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 糖尿病 / 2型糖尿病 / β細胞量 / 肥満 / 日本人 / 膵内分泌細胞 / 組織学

Outline of Final Research Achievements

Aim of the study was to explore physiological and pathological regulations in beta cell mass in humans (Japanese). We have examined effects of obesity and diabetes on alpha and beta cell mass in humans and found a reduction in beta cell mass by 46% in Japanese patients with type 2 diabetes (Inaishi J et al. J Clin Endocrinol Metab 2016). Deleterious effects of pancreatic fat accumulation on beta cell has been shown in animal studies, which is postulated as a cause of type 2 diabetes development. By examining human pancreas, we have shown that intra-pancreatic fat accumulation has little effect on beta cell mass and glucose intolerance (Murakami R et al. J Clin Endocrinol Metab 2017).

Research Products

• [Journal Article] 膵α・β細胞容積 (2018)
  • Author(s): 税所芳史
  • Journal Title: 糖尿病 Volume: 61 Pages: 48-50
• [Journal Article] Pancreas fat and beta cell mass in humans with and without diabetes: An analysis in the Japanese population. (2017)
  • Author(s): Murakami R, Saisho Y, Watanabe Y, Inaishi J, Tsuchiya T, Kou K, Sato S, Kitago M, Kitagawa Y, Yamada T, Itoh H.
  • Journal Title: The Journal of Clinical Endocrinology & Metabolism Volume: 102 Issue: 9 Pages: 3251-3260
  • DOI: 10.1210/jc.2017-00828
  • Peer Reviewed
• [Journal Article] Ethnic Similarities and Differences in the Relationship between Beta Cell Mass and Diabetes (2017)
  • Author(s): Inaishi Jun、Saisho Yoshifumi
  • Journal Title: J Clin Med Volume: 6 Issue: 12 Pages: 113-113
  • DOI: 10.3390/jcm6120113
  • Peer Reviewed / Open Access
• [Journal Article] 2型糖尿病の発症メカニズム 膵β細胞workload仮説 (2017)
  • Author(s): 税所芳史
  • Journal Title: 臨床化学 Volume: 46 Pages: 157-159
• [Journal Article] Effects of obesity and diabetes on alpha and beta cell mass in surgically resected human pancreas (2016)
  • Author(s): Inaishi J, Saisho Y, Sato S, Kou K, Murakami R, Watanabe Y, Kitago M, Kitagawa Y, Yamada T, Itoh H
  • Journal Title: J Clin Endocrinol Metab Volume: 101 Issue: 7 Pages: 2874-82
  • DOI: 10.1210/jc.2016-1374
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 肥満、糖尿病におけるヒト膵δ・PP細胞量の変化についての検討 (2017)
  • Author(s): 渡辺雄祐、税所芳史、稲石淳、村上理恵、土屋多美、佐藤誠治、侯金成、北郷実、北川雄光、山田健人、伊藤裕
  • Organizer: 第60回日本糖尿病学会 名古屋
• [Presentation] ヒト膵脂肪含有量とα・β細胞量との関連についての検討 (2017)
  • Author(s): 村上理恵、税所芳史、稲石淳、渡辺雄祐、土屋多美、佐藤誠治、侯金成、山田健人、北郷実、北川雄光、伊藤裕
  • Organizer: 第60回日本糖尿病学会 名古屋
• [Presentation] Relationship between intra-pancreatic fat content and beta and alpha cell mass in humans with and without diabetes (2017)
  • Author(s): Murakami R, Saisho Y et al.
  • Organizer: 77th Scientific Sessions of the American Diabetes Association (ADA) San Diego, CA
  • Int'l Joint Research
• [Presentation] Effects of obesity and diabetes on delta and pancreatic polypeptide cell mass and the relative change among islet endocrine cell mass in humans (2017)
  • Author(s): Watanabe Y, Saisho Y et al.
  • Organizer: 77th Scientific Sessions of the American Diabetes Association (ADA) San Diego, CA
  • Int'l Joint Research
• [Presentation] Relathinship between intra-pancreatic fat content and beta and alpha cell mass in humans with and without diabetes (2016)
  • Author(s): Murakami R, Saisho Y, Kou K, Sato S, Watanabe Y, Kitago M, Kitagawa Y, Yamada T, Itoh H
  • Organizer: 52nd Annual Meeting of the European Association for the Study of Diabetes (EASD)
  • Place of Presentation: Munich, Germany
  • Year and Date: 2016-09-12
  • Int'l Joint Research
• [Presentation] ヒト膵脂肪含有量とα・β細胞量との関連についての検討 (2016)
  • Author(s): 村上理恵、税所芳史、侯金成、佐藤誠治、稲石淳、渡辺雄祐、北郷実、北川雄光、山田健人、伊藤裕
  • Organizer: 第34回日本肥満症治療学会学術集会
  • Place of Presentation: 東京コンベンションセンター（東京都中央区）
  • Year and Date: 2016-07-01
• [Presentation] 膵摘出例を用いた肥満、糖尿病でのヒトα・β細胞量の変化についての検討 (2016)
  • Author(s): 渡辺雄祐、税所芳史、稲石淳、佐藤誠治、村上理恵、侯金成、北郷実、北川雄光、山田健人、伊藤裕
  • Organizer: 第34回日本肥満症治療学会学術集会
  • Place of Presentation: 東京コンベンションセンター（東京都中央区）
  • Year and Date: 2016-07-01
• [Presentation] ヒト膵脂肪含有量とα・β細胞量との関連についての検討 (2016)
  • Author(s): 村上理恵、税所芳史、稲石淳、渡辺雄祐、佐藤誠治、侯金成、山田健人、北郷実、北川雄光、伊藤裕
  • Organizer: 第59回日本糖尿病学会年次学術集会
  • Place of Presentation: 国立京都国際会館（京都府京都市）
  • Year and Date: 2016-05-19
• [Presentation] 肥満、糖尿病でのヒトα・β細胞量の変化についての検討 (2016)
  • Author(s): 稲石淳、税所芳史、佐藤誠治、村上理恵、渡辺雄祐、侯金成、北郷実、北川雄光、山田健人、伊藤裕
  • Organizer: 第59回日本糖尿病学会年次学術集会
  • Place of Presentation: 国立京都国際会館（京都府京都市）
  • Year and Date: 2016-05-19
• [Presentation] Effects of obesity and diabetes on alpha and beta cell mass in surgically removed human pancreas (2015)
  • Author(s): Inaishi J, Saisho Y, Kou K, Sato S, Murakami R, Yamada T, Kitago M, Kitagawa Y, Itoh H
  • Organizer: 51st Annual Meeting of the European Association for the Study of Diabetes (EASD)
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2015-09-14
  • Int'l Joint Research
• [Presentation] 肥満、糖尿病でのヒトα・β細胞量の変化についての検討 (2015)
  • Author(s): 稲石淳、税所芳史、村上理恵、佐藤誠治、侯金成、北郷実、北川雄光、山田健人、伊藤裕
  • Organizer: 第58回日本糖尿病学会
  • Place of Presentation: 海峡メッセ下関（山口県下関市）
  • Year and Date: 2015-05-21
• [Presentation] 膵摘出症例におけるβ細胞量と糖代謝指標の関連についての検討 (2015)
  • Author(s): 稲石淳、税所芳史、村上理恵、佐藤誠治、侯金成、北郷実、北川雄光、山田健人、伊藤裕
  • Organizer: 第88回日本内分泌学会
  • Place of Presentation: ホテルニューオータニ東京（東京都千代田区）
  • Year and Date: 2015-04-23