• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Identification of susceptibility genes for autoimmunity and beta-cell specificity of type 1 diabetes

Research Project

Project/Area Number 15K09404
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Metabolomics
Research InstitutionKindai University

Principal Investigator

IKEGAMI Hiroshi  近畿大学, 医学部, 教授 (20221062)

Co-Investigator(Kenkyū-buntansha) 馬場谷 成  近畿大学, 医学部, 講師 (10449837)
廣峰 義久  近畿大学, 医学部, 講師 (30460851)
川畑 由美子  近畿大学, 医学部, 准教授 (80423185)
能宗 伸輔  近畿大学, 医学部, 講師 (90460849)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords1型糖尿病 / 自己免疫 / 遺伝子 / 疾患感受性 / 臓器特異性 / 自己免疫疾患 / 免疫寛容 / バセドウ病 / 円形脱毛症 / 標的臓器
Outline of Final Research Achievements

The purpose of this study was to identify genes responsible for both autoimmuninty and organ-specificity of type 1 diabetes. Type 1 diabetes and autoimmune thyroid diseases (AITD), alopecia areata and AITD, are often develop in the same individuals, whereas type 1 diabetes and AA are very rare to be observed in the same individuals. HLA-DR4 haplotype (DRB1*04:05-DQB1*04:01) was found to be responsible for beta-cell specificity in autoimmune diseases. targeted disruption of MafA in NOD mice resulted in protection, but not accerelation, of beta-cell autoimmunity and type 1 diabetes. Accumulation of regulatory T-cells in insulitis legion was suggested to be possible mechanism of protection from beta-cell autoimmunity and type 1 diabetes.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (20 results)

All 2018 2017 2016 2015

All Journal Article (14 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 14 results,  Open Access: 12 results,  Acknowledgement Compliant: 2 results) Presentation (6 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] Congenic mapping and candidate gene analysis for streptozotocin-induced diabetes susceptibility locus on mouse chromosome 112018

    • Author(s)
      Maegawa Tomoki、Miyasaka Yuki、Kobayashi Misato、Babaya Naru、Ikegami Hiroshi、Horio Fumihiko、Takahashi Masahide、Ohno Tamio
    • Journal Title

      Mammalian Genome

      Volume: 29 Issue: 3-4 Pages: 273-280

    • DOI

      10.1007/s00335-018-9742-y

    • NAID

      120006517666

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Insulin deficiency with and without glucagon: A comparative study between total pancreatectomy and type 1 diabetes.2018

    • Author(s)
      Niwano F, Hiromine Y, Noso S, Babaya N, Ito H, Yasutake S, Matsumoto I, Takeyama Y, Kawabata Y, Ikegami H.
    • Journal Title

      J Diabetes Investig.

      Volume: 9 Issue: 5 Pages: 1084-1090

    • DOI

      10.1111/jdi.12799

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of dosage and dosing frequency on the efficacy and safety of high-dose metformin in Japanese patients with type 2 diabetes mellitus.2018

    • Author(s)
      Kanto K, Ito H, Noso S, Babaya N, Hiromine Y, Taketomo Y, Toma J, Niwano F, Yasutake S, Kawabata Y, Ikegami H.
    • Journal Title

      J Diabetes Investig.

      Volume: 9 Issue: 3 Pages: 587-593

    • DOI

      10.1111/jdi.12755

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 自己免疫疾患の標的臓器を決定する因子 -なぜ膵β細胞だけが攻撃されるのか-2018

    • Author(s)
      池上博司、能宗伸輔、川畑由美子
    • Journal Title

      日本体質医学会雑誌

      Volume: 80

    • NAID

      40021496848

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Common phenotype and different non-HLA genes in Graves' disease and alopecia areata2017

    • Author(s)
      Taketomo Y, Noso S, Babaya M, Hiromine Y, Ito H, Kanto K, Niwano F, Oiso N, Kawada A, Kawabata Y, Ikegami H
    • Journal Title

      Hum Immunol

      Volume: 78 Issue: 2 Pages: 185-189

    • DOI

      10.1016/j.humimm.2016.10.019

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A rare HLA genotype in two siblings with type 1 diabetes in a Japanese family clustered with type 1 diabetes2017

    • Author(s)
      Ina Y, Kawabata Y, Sakamoto R, Sekiguchi N and Ikegami H
    • Journal Title

      J Diabetes Investig

      Volume: 印刷中 Issue: 6 Pages: 762-765

    • DOI

      10.1111/jdi.12628

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical features of cases of seroconversion of anti-glutamic acid decarboxylase antibody during the clinical course of type 2 diabetes: a nationwide survey in Japan2017

    • Author(s)
      Oikawa Y, Shimada A, Awata T, Fukui T, Ikegami H, Imagawa A, Kajio H, Kawabata Y, Kawasaki E, Miura J, Osawa H, Takahashi K, Tanaka S, Uchigata Y, Yasuda H, Yasuda K, Hanafusa T, Kobayashi T
    • Journal Title

      Diabetol Int

      Volume: 8 Issue: 3 Pages: 306-315

    • DOI

      10.1007/s13340-017-0312-4

    • NAID

      40021293601

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case of fulminant type 1 diabetes mellitus with a precipitous decrease in pancreatic volume, induced by nivolmab for malignant melanoma: analysis of HLA and CTLA4 porymorphism.2017

    • Author(s)
      Ishikawa K, Shono-Saito T, Yamate T, Kai Y, Sakai T, Shimizu F, Yamada Y, Mori H, Noso S, Ikegami H, Kojima H, Tanaka H, Fujiwara S, Hatano Y
    • Journal Title

      Eur J Dermatol

      Volume: 27 Issue: 2 Pages: 184-185

    • DOI

      10.1684/ejd.2016.2923

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Case report: schwannoma arising from the unilateral adrenal area with bilateral hyperaldosteronism.2017

    • Author(s)
      Babaya N, Makutani Y, Noso S, Hiromine Y, Ito H, Taketomo Y, Ueda K, Ushijima H, Komoike Y, Yamazaki Y, Sasano H, Kawabata Y, Ikegami H.
    • Journal Title

      BMC Endocr Disord.

      Volume: 17 Issue: 1 Pages: 74-74

    • DOI

      10.1186/s12902-017-0225-z

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical and Genetic Characteristics of Non-Insulin-Requiring Glutamic Acid Decarboxylase (GAD) Autoantibody-Positive Diabetes: A Nationwide Survey in Japan2016

    • Author(s)
      Yasui J, Kawasaki E, Tanaka S, Awata T, Ikegami H, Imagawa A, Uchigata Y, Osawa H, Kajio H, Kawabata Y, Shimada A, Takahashi K, Yasuda K, Yasuda H, Hanafusa T, Kobayashi T, Japan Diabetes Society Committee on Type 1 Diabetes Mellitus Research
    • Journal Title

      PLoS ONE

      Volume: 11 Issue: 5 Pages: 1-12

    • DOI

      10.1371/journal.pone.0155643

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Risk factors of sudden death and cardiac arrest at the onset of fulminant type 1 diabetes mellitus.2016

    • Author(s)
      Yamaguchi aden MY, Imagawa A, Iwahashi H, Shimomura I, Awata T, Ikegami H, Uchigata Y, Osawa H, Kajio H, Kawasaki E, Kawabata Y, Shimada A, Takahashi K, Tanaka S, Yasuda K, Yasuda H, Kobayashi T, Hanafusa T
    • Journal Title

      Diabetology Int

      Volume: なし Issue: 3 Pages: 281-288

    • DOI

      10.1007/s13340-015-0247-6

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immune checkpoint therapy and type 1 diabetes2016

    • Author(s)
      Ikegami H, Kawabata Y, Noso S
    • Journal Title

      Diabetol Int

      Volume: 7 Issue: 3 Pages: 221-227

    • DOI

      10.1007/s13340-016-0276-9

    • NAID

      40020934033

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Organ specificity in autoimmune diseases: thyroid and islet autoimmunity in alopecia areata.2015

    • Author(s)
      Noso S, Park C, Babaya N, Hiromine Y, Harada T, Ito H, Taketomo Y, Oiso N, Kawada A, Suzuki T, Kawabata Y, Ikegami H
    • Journal Title

      J Clin Endocrinol Metab

      Volume: 100 Issue: 5 Pages: 1976-1983

    • DOI

      10.1210/jc.2014-3985

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Low PD-1 expression in peripheral CD4+ T-cells in Japanese patients with autoimmune type 1 diabetes.2015

    • Author(s)
      Fujisawa R, Haseda F, Tsutsumi C, Hiromine Y, Noso S, Kawabata Y, Mitsui S, Terasaki J, Ikegami H, Imagawa A, Hanafusa T.
    • Journal Title

      Clin Exp Immunol

      Volume: Feb 12 Issue: 3 Pages: 452-457

    • DOI

      10.1111/cei.12603

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Identification of genetic variants co-segregated with islet-autoimmunity in multiplex families of type 1 diabetes by genome-wide exome analysis2017

    • Author(s)
      Noso S, Hosomichi K, Hiromine Y, Ito H, Taketomo Y, Kawabata Y, Ikegami H
    • Organizer
      Immunology of Diabetes Society, 15th International Congress 2017
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2017-01-20
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Whole-exome sequencing in rare families identified novel genetic variants for familial type 1 diabetes2017

    • Author(s)
      Noso S, Hosomichi K, Babaya N, Hiromine Y, Ito H, Taketomo Y, Kawabata Y, Ikegami H
    • Organizer
      53rd Annual Meeting of the European Association for the Study of Diabetes
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Insulin dependency with and without glucagon: marked difference in insulin requirement between patients with total pancreatectomy and type 1 diabetes2017

    • Author(s)
      Hiromine Y, Noso S, Babaya N, Ito H, Niwano F, Matsumoto I, Takeyama Y, Kawabata Y, Ikegami H
    • Organizer
      53rd Annual Meeting of the European Association for the Study of Diabetes
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 糖尿病の体質:予防と治療の個別化へむけて2015

    • Author(s)
      池上博司
    • Organizer
      第65回日本体質医学会総会 シンポジウム
    • Place of Presentation
      札幌(札幌コンベンションセンター)
    • Year and Date
      2015-07-04
    • Related Report
      2015 Research-status Report
  • [Presentation] 1型糖尿病の遺伝:common variantからrare variantまで2015

    • Author(s)
      川畑由美子、能宗伸輔、池上博司
    • Organizer
      第58回日本糖尿病学会年次学術集会 シンポジウム
    • Place of Presentation
      下関(ぱしふぃっくびぃなす)
    • Year and Date
      2015-05-21
    • Related Report
      2015 Research-status Report
  • [Presentation] Identification of genetic loci linked to type 1 diabetes susceptibility by linkage analysis with whole exome sequencing in clustered family2015

    • Author(s)
      Noso S, Kawabata Y, Babaya N, Hiromine Y, Hosomichi K, Ikegami H
    • Organizer
      Immunology of Diabetes Society, 14th International Congress
    • Place of Presentation
      Munich, Germany(Hilton Munich Park)
    • Year and Date
      2015-04-12
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

URL: 

Published: 2015-04-16   Modified: 2020-01-20  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi