The central regulatory mechanism of FGF21 on carbohydrate preference
| Project/Area Number |
15K09405
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | University of the Ryukyus (2016-2017)
National Institute for Physiological Sciences (2015) |
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Principal Investigator |
Okamoto Shiki 琉球大学, 医学(系)研究科(研究院), 特命講師 (40342919)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | FGF21 / 炭水化物嗜好性 / AMPK |
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| Outline of Final Research Achievements |
The activation of an AMPK in a subset of CRH-positive neurons in the paraventricular hypothalamus mediates the fasting-induced increase in high carbohydrate selection. The hepatokine, FGF21, modulates AMPK responsible CRH neurons directly. This mechanism might contribute the rapid recovery from the energy crisis in the starvation.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Activation of AMPK-Regulated CRH Neurons in the PVH is Sufficient and Necessary to Induce Dietary Preference for Carbohydrate over Fat.2018
Author(s)
Okamoto S, Sato T, Tateyama M, Kageyama H, Maejima Y, Nakata M, Hirako S, Matsuo T, Kyaw S, Shiuchi T, Toda C, Sedbazar U, Saito K, Asgar NF, Zhang B, Yokota S, Kobayashi K, Foufelle F, Ferré P, Nakazato M, Masuzaki H, Shioda S, Yada T, Kahn BB, Minokoshi Y.
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Journal Title
Cell Rep.
Volume: 22
Issue: 3
Pages: 706-721
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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