Genomic and epigenomic regulations of metabolic syndrome related diseases.
| Project/Area Number |
15K09409
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 糖尿病 / メタボリックシンドローム / 内科 / エピゲノム |
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| Outline of Final Research Achievements |
Accumulation of adipose tissue cause insulin resistance and lead to metabolic syndrome and type 2 diabetes mellitus. Genomic changes in protein coding lesion of signaling molecules correlated to structural changes and disease severity. We analyzed epigenetic change in adipose tissue and found fat-specific epigenetic changes. Genetic and epigenetic regulations of protein structure and gene expressions are supposed to be important to disease progression. These findings may contribute to elucidate the molecular mechanisms of metabolic syndrome and type 2 diabetes mellitus.
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] Structural Basis and Genotype-Phenotype Correlations of INSR Mutations Causing Severe Insulin Resistance.2017
Author(s)
Hosoe J, Kadowaki H, Miya F, Aizu K, Kawamura T, Miyata I, Satomura K, Ito T, Hara K, Tanaka M, Ishiura H, Tsuji S, Suzuki K, Takakura M, Boroevich KA, Tsunoda T, Yamauchi T, Shojima N, Kadowaki T
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Journal Title
Diabetes
Volume: 66
Issue: 10
Pages: 2713-2723
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Severe Insulin Resistance Caused by Mutations in INSR: Genotype-phenotype Correlations and Structural Characterization of the Mutations.2017
Author(s)
Jun Hosoe, Hiroko Kadowaki, Fuyuki Miya, Katsuya Aizu, Ichiro Miyata, Tomoyuki Kawamura, Kenichi Satomura, Takeru Ito, Ken Suzuki, Tatsuhiko Tsunoda, Toshimasa Yamauchi, Nobuhiro Shojima, Takashi Kadowaki
Organizer
77th Scientific Sessions of the American Diabetes Association
Related Report
Int'l Joint Research
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[Presentation] Genotype-phenotype and structure-phenotype correlations of the insulin receptor gene mutations in patients with severe insulin resistance.2017
Author(s)
Jun Hosoe, Hiroko Kadowaki, Fuyuki Miya, Minaka Takakura, Katsuya Aizu, Ichiro Miyata, Tomoyuki Kawamura, Kenichi Satomura, Takeru Ito, Kazuo Hara, Masaki Tanaka, Hiroyuki Ishiura, Shoji Tsuji, Ken Suzuki, Tatsuhiko Tsunoda, Nobuhiro Shojima, Toshimasa Yamauchi, Takashi Kadowaki
Organizer
2017 American Society of Human Genetics (ASHG) Meeting
Related Report
Int'l Joint Research
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[Presentation] インスリン受容体遺伝子変異に関するタンパク質立体構造への影響と表現型の相関(structure-phenotype correlation)2017
Author(s)
細江隼,門脇弘子,宮冬樹,会津克哉,宮田市郎,川村智行,里村憲一,鈴木顕,高倉美菜香,角田達彦,山内敏正,庄嶋伸浩,門脇 孝
Organizer
第60回日本糖尿病学会年次学術集会
Place of Presentation
名古屋国際会議場(名古屋)
Related Report
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[Presentation] Severe Insulin Resistance Caused by Mutations in INSR: Genotype-Phenotype2017
Author(s)
JUN HOSOE, HIROKO KADOWAKI, FUYUKI MIYA, KATSUYA AIZU, ICHIRO MIYATA, TOMOYUKI KAWAMURA, KENICHI SATOMURA, TAKERU ITO, KEN SUZUKI, TATSUHIKO TSUNODA, TOSHIMASA YAMAUCHI, NOBUHIRO SHOJIMA, TAKASHI KADOWAKI
Organizer
American Diabetes Association’s 77th Scientific Sessions
Place of Presentation
San Diego, California
Related Report
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