| Project/Area Number |
15K09423
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Nagoya University |
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Principal Investigator |
Tanaka Miyako 名古屋大学, 環境医学研究所, 助教 (60622793)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMASAKI Sho 大阪大学, 微生物病研究所, 教授 (40312946)
Uezumi Akiyoshi 地方独立行政法人東京都健康長寿医療センター, 東京都健康長寿医療センター研究所, 専門副部長 (60434594)
Ogawa Yoshihiro 九州大学, 大学院医学研究院, 教授 (70291424)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | マクロファージ / 脂肪組織線維化 / 内因性リガンド / Mincle / 肥満 / 異所性脂肪 / 病原体センサー |
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| Outline of Final Research Achievements |
I developed a new animal model of adipose tissue fibrosis instead of high fat diet-induced obese model, which takes at least 4 months for adipose tissue fibrosis. Applying an ischemia-reperfusion model to the adipose tissue, I could establish the new model, which takes only 2 weeks for adipose tissue fibrosis involved in the upregulation of Mincle gene expression and CLS (crown-like structure) formation. I also identified the adipose tissue fibroblasts using high fat diet-induced obese mice that express GFP under collagen promoter. I found that the GFP-positive cells in epididymal fat tissue are almost all positive for PDGFRα. In addition, the character of PDGFRα-positive cells in epididymal fat tissue is different from that in subcutaneous fat tissue and more active type of fibroblasts.
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