| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Knockout mouse of GABAB receptors in the reward system consumed a more high fat diet than wild-type mice when they were given the food intermittently. There were no significant differences in body weight or glucose tolerance between genotypes, suggesting that GABAB receptors in the reward system is not involved in the regulation of energy homeostasis, Baclofen, a GABAB agonist, decreased the consumption of the high fat diet when given just before the high fat diet was presented in wild-type, but not in the knockout mice in the intermittent high fat die protocol. These data indicate that the GABAB neurons in the reward system plays an inhibitory role in the binge eating of a high fat diet.
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