Analysis of the mechanisms of beta cell destruction by DNA and RNA viruses identified in the pancreases of patients with fulminant type 1 diabetes
| Project/Area Number |
15K09429
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Osaka Medical College (2016-2017)
Osaka University (2015) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
岩橋 博見 大阪大学, 医学系研究科, 寄附講座准教授 (60397627)
福井 健司 大阪大学, 医学系研究科, 助教 (60513009)
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| Research Collaborator |
YONEDA Sho
HOSOKAWA Yoshiya
BADEN Megu
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 劇症１型糖尿病 / １型糖尿病 |
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| Outline of Final Research Achievements |
We identified ZBP1 and RIG-I (virus receptors) and IRF3 (transcription factor for type I interferon production) as candidate key molecules by the analysis of pancreas specimens of a fulminant type 1 diabetic patient with cytomegalovirus reactivation. We also established in vitro treatment model of fulminant type 1 diabetes by using insulin positive cells induced from healthy individuals-derived iPS cells and identified GLP-1 receptor agonist as a candidate drug which could reduce apoptosis and beta cell destruction.
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Report
(4 results)
Research Products
(13 results)
