| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
The present study using osteoblast-specific AMPK knockout mice showed that deletion of osteoblast AMPK induced retardation of postnatal bone development, as well as reduction in trabecular and cortical bone volume, by decreasing osteoblast differentiation and increasing RANKL expression. These findings suggest that osteoblast AMPK plays important roles in bone modeling and remodeling. Accordingly, activation of osteoblast AMPK may be a candidate for treatment of osteoporosis with high bone turnover, as well as diabetes-related osteoporosis, although further studies are necessary to clarify the roles of AMPK in bone.
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