Analysis and clinical application of BMP in the regulation of H-P-O axis.
Project/Area Number |
15K09434
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Endocrinology
|
Research Institution | Okayama University |
Principal Investigator |
Otsuka Fumio 岡山大学, 医歯薬学総合研究科, 教授 (40362967)
|
Project Period (FY) |
2015-10-21 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 卵巣 / 下垂体 / 視床下部 / 生殖内分泌 / 骨形成蛋白 / ステロイド合成 / 骨形成タンパク / BMP |
Outline of Final Research Achievements |
Female infertility is an urgent issue to be solved; however, the detailed regulatory mechanism of the reproductive axis composed of hypothalamus-pituitary-ovary (HPO) has yet to be fully clarified. We investigated the physiological and endocrinological significance of bone morphogenetic protein (BMP) molecules in the ovarian follicles as well as in the HPO axis. Here, we revealed that the BMP system plays critical roles as a intracellular communicator in the ovarian follicle and that it also works as a fine modulator with various circadian regulators in the HPO axis. These findings would be informative for the clinical application of BMPs for diagnosis and treatment of female infertility.
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Report
(4 results)
Research Products
(76 results)
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[Journal Article] Antiobesity action of ACAM by modulating the dynamics of cell adhesion and actin polymerization in adipocytes.2016
Author(s)
Murakami K, Eguchi J, Hida K, Nakatsuka A, Katayama A, Sakurai M, Choshi H, Furutani M, Ogawa D, Takei K, Otsuka F, Wada J
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Journal Title
Diabetes
Volume: 65(5)
Issue: 5
Pages: 1255-1267
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] 体重減少2016
Author(s)
灘 隆宏、大塚文男
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Journal Title
日本病院総合診療医学会雑誌
Volume: 10
Pages: 15-18
NAID
Related Report
Peer Reviewed
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