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Development of a new detection system of autoantibodies in Hashimoto encephalopathy and search for the pleiotropy

Research Project

Project/Area Number 15K09440
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Endocrinology
Research InstitutionFukui Prefectural University

Principal Investigator

YONEDA Makoto  福井県立大学, 看護福祉学部, 教授 (70270551)

Co-Investigator(Kenkyū-buntansha) 篁 俊成  金沢大学, 医学系, 教授 (00324111)
樋口 理  独立行政法人国立病院機構長崎川棚医療センター(臨床研究部), その他の研究科, 研究員(移行) (50361720)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords橋本脳症 / 抗NAE抗体 / 分子診断マーカー / LIPS法 / 生物発光
Outline of Final Research Achievements

Hashimoto’s encephalopathy is an autoimmune neuropsychiatric disorder associated with chronic thyroiditis, Hashimoto’s thyroiditis. We discovered specific autoantibodies (Abs) against NAE protein in the patient’s serum. In this research, we developed a new detection system of anti-NAE Abs by a bioluminescence/immunoprecipitation method (luciferase immunoprecipitation systems; LIPS). We were succeeded in the construction of a plasmid expressing a NAE/luciferase chimeric protein, expressed it in a human cultured cells HEK293, and purified the recombinant protein. We verified the immunoreactivity and bioluminescence of the recombinant NAE/luciferase chimeric protein with the patient’s serum. This LIPS system to detect anti-NAE Abs showed a similar tendency to that in the previous immunoblot method.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (38 results)

All 2018 2017 2016 2015

All Journal Article (21 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Open Access: 5 results,  Acknowledgement Compliant: 2 results) Presentation (7 results) (of which Int'l Joint Research: 4 results,  Invited: 2 results) Book (10 results)

  • [Journal Article] Limbic encephalitis associated with anti-NH2-terminal of α-enolase antibodies: A clinical subtype of Hashimoto encephalopathy.2017

    • Author(s)
      Kishitani T, Matsunaga A, Ikawa M, Hayashi K, Yamamura O, Hamano T, Watanabe O, Tanaka K, Nakamoto Y, Yoneda M
    • Journal Title

      Medicine

      Volume: 96(10) Issue: 10 Pages: e6181-e6181

    • DOI

      10.1097/md.0000000000006181

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Precise Evaluation of Striatal Oxidative Stress Corrected for Severity of Dopaminergic Neuronal Degeneration in Patients with Parkinson’s Disease: A Study with <sup>62</sup>Cu-ATSM PET and <sup>123</sup>I-FP-CIT SPECT2017

    • Author(s)
      Neishi H, Ikawa M, Okazawa H, Tsujikawa T, Arishima H, Kikuta KI, Yoneda M
    • Journal Title

      European Neurology

      Volume: 78 Issue: 3-4 Pages: 161-168

    • DOI

      10.1159/000479627

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical findings of a probable case of MM2-cortical-type sporadic Creutzfeldt-Jakob disease with antibodies to anti-N-terminus of α-enolase2017

    • Author(s)
      4.Hayashi Y, Yamada M, Kimura A, Asano T, Satoh K, Kitamoto T, Yoneda M, Inuzuka T
    • Journal Title

      Prion

      Volume: 11(6) Pages: 454-464

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Case of Hashimoto's encephalopathy showing atypical clinical course with magnetic resonance imaging abnormalities2017

    • Author(s)
      Hirose D, Hirao K, Kaneko Y, Fukasawa R, Sato T, Shimizu S, Kanetaka H, Umahara T, Sakurai H, Yoneda M, Hanyu H
    • Journal Title

      Geriatr Gerontol Int

      Volume: 17(8) Issue: 8 Pages: 1235-1237

    • DOI

      10.1111/ggi.13057

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of Autoantibodies and the Efficacy of Immunotherapy for Autoimmune Cerebellar Ataxia2016

    • Author(s)
      Nanri K, Okuma M, Sato S, Yoneda M, Taguchi T, Mitoma H, Yamada J, Unezaki S, Nagatani T, Otsubo S, Sugawara M, Tanaka N, Mizusawa H
    • Journal Title

      Internal Medicine

      Volume: 55 Issue: 5 Pages: 449-454

    • DOI

      10.2169/internalmedicine.55.5156

    • NAID

      130005132612

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Acute Disseminated Encephalomyelitis Following Immunization with Human Papillomavirus Vaccines.2016

    • Author(s)
      Yoneda M
    • Journal Title

      Intern Med

      Volume: 55(21) Pages: 3077-3078

    • NAID

      130005276912

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] One point advice,橋本病と小脳失調.2016

    • Author(s)
      米田誠
    • Journal Title

      Medical Practice

      Volume: 33 Pages: 816-816

    • Related Report
      2016 Research-status Report
  • [Journal Article] 橋本脳症の臨床スペクトラムとその病態.2016

    • Author(s)
      米田誠
    • Journal Title

      神経治療学

      Volume: 33 Pages: 27-33

    • Related Report
      2016 Research-status Report
  • [Journal Article] 内分泌機能異常に伴う認知症;治せる認知症-2016

    • Author(s)
      松永晶子,米田誠
    • Journal Title

      Brain & Nerve

      Volume: 68 Pages: 399-405

    • Related Report
      2016 Research-status Report
  • [Journal Article] 橋本脳症2016

    • Author(s)
      米田誠
    • Journal Title

      Modern Physician

      Volume: 36(7) Pages: 692-695

    • Related Report
      2016 Research-status Report
  • [Journal Article] 橋本脳症;辺縁系脳炎との関連から-2016

    • Author(s)
      米田誠
    • Journal Title

      Neuroinfection

      Volume: 21 Pages: 14-17

    • Related Report
      2016 Research-status Report
  • [Journal Article] 橋本脳症の症状、診断、治療.2016

    • Author(s)
      米田誠
    • Journal Title

      日本医事新報社

      Volume: 4816 Pages: 60-60

    • Related Report
      2016 Research-status Report
  • [Journal Article] Consensus Paper: NeuroimmuneMechanisms of Cerebellar Ataxias2015

    • Author(s)
      Mitoma H, Adhikari K, Aeschlimann D, Chattopadhyay P, Hadjivassiliou M, Hampe CS, Honnorat J, Joubert B, Kakei S, Lee J, Manto M, Matsunaga A, Mizusawa H,Nanri K, Shanmugarajah P, Yoneda M, Yuki N.
    • Journal Title

      Cerebellum

      Volume: on line Issue: 2 Pages: 213-32

    • DOI

      10.1007/s12311-015-0664-x

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 免疫グロブリン静注療法,血漿交換療法に抵抗性で,長期ステロイド経口投与が有効であった辺縁系型の橋本脳症の一例2015

    • Author(s)
      徳田直輝,今井啓輔,笠井高士,木村彩香,阿部能成,富永敏行,福居顯二,米田誠,中川正法,水野敏樹
    • Journal Title

      臨床神経

      Volume: 55 Pages: 737-41

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 抗αエノラーゼN末端抗体陽性のレヴィ小体型認知症の1例 橋本脳症との鑑別診断2015

    • Author(s)
      伊倉 崇浩, 藤城 弘樹, 高橋 幸利, 米田誠, 斎藤 知之, 千葉 悠平, 鎌田 鮎子, 勝瀬 海, 平安 良雄
    • Journal Title

      Brain and Nerve

      Volume: 67 Pages: 967-72

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 橋本脳症.α-エノラーゼ,自己免疫性脳炎:抗原・抗体は何をしている?2015

    • Author(s)
      米田誠
    • Journal Title

      Clin Neurosci

      Volume: 33 Pages: 104-7

    • Related Report
      2015 Research-status Report
  • [Journal Article] 橋本脳症.Ⅱ.知っておきたい神経疾患2015

    • Author(s)
      松永晶子,米田誠
    • Journal Title

      精神科

      Volume: 26 Pages: 159-63

    • Related Report
      2015 Research-status Report
  • [Journal Article] 橋本脳症.免疫性神経疾患 - 基礎・臨床研究の最新知見 -2015

    • Author(s)
      米田誠
    • Journal Title

      日本臨床(別冊)

      Volume: 73 Pages: 603-6

    • Related Report
      2015 Research-status Report
  • [Journal Article] 橋本脳症.免疫症候群(Ⅰ) -その他の免疫疾患を含めて-2015

    • Author(s)
      松永晶子,米田誠
    • Journal Title

      日本臨床別冊(増刊)領域別症候群シリーズ

      Volume: 34 Pages: 99-101

    • Related Report
      2015 Research-status Report
  • [Journal Article] 橋本脳症.免疫性神経疾患 - 病態解明と治療の最前線2015

    • Author(s)
      米田誠
    • Journal Title

      医学のあゆみ

      Volume: 255 Pages: 533-5

    • Related Report
      2015 Research-status Report
  • [Journal Article] 内分泌疾患に伴う認知症2015

    • Author(s)
      松永晶子,米田誠
    • Journal Title

      Brain and Nerve

      Volume: 68 Pages: 399-405

    • Related Report
      2015 Research-status Report
  • [Presentation] The clinical features and pathophysiology of ataxic form of Hashimoto’s encephalopathy2018

    • Author(s)
      Makoto Yoneda, Akiko Matsunaga, Masamichi Ikawa, Yasunari Nakamoto, Hiroshi Mitoma
    • Organizer
      The 70th Annual Meeting of American Academy of Neurology (AAN)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Autoimmune limbic encephalitis associated with anti-NAE antibodies as a clinical subtype of Hashimoto’s encephalopathy2017

    • Author(s)
      Akiko Matsunaga, Toru Kishitani, Masamichi Ikawa, Kouji Hayashi, Osamu Yamamura, Tadanori Hamano, Osamu Watanabe, Keiko Tanaka, Yasunari Nakamoto, Makoto Yoneda
    • Organizer
      World Congress of Neurology2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 認知症と橋本脳症,シンポジウム「自己免疫性神経疾患と認知症」2017

    • Author(s)
      米田誠
    • Organizer
      第36回 日本認知症学会学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 抗甲状腺抗体と抗GAD抗体が陽性であった自己免疫性小脳失調症の一例2016

    • Author(s)
      野村俊,高橋祐介,阿部隆太,小川有香,宮崎大吾,関島良樹,米田誠,池田修一
    • Organizer
      第21回日本神経感染症学会
    • Place of Presentation
      金沢東急ホテル(石川県,金沢市)
    • Year and Date
      2016-10-21
    • Related Report
      2016 Research-status Report
  • [Presentation] 橋本脳症の診断と治療.シンポジウム「自己免疫性脳炎の臨床像と治療」2015

    • Author(s)
      米田誠
    • Organizer
      第20回日本神経感染症学会総会・学術大会
    • Place of Presentation
      ホテルメルパルク長野
    • Year and Date
      2015-10-22
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Clinical and immunological features of limbic form of Hashimoto’s encephalopathy2015

    • Author(s)
      Toru Kishitani, Akiko Matsunaga, Masamichi Ikawa, Tomomi Kame, Osamu Yamamura, Tadanori Hamano, Yasunari Nakamoto, Makoto Yoneda.
    • Organizer
      The 67th Annual Meeting of American Academy of Neurology
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2015-04-18
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Pathophysiological decrease in the regional cerebral blood flow in Hashimoto’s encephalopathy: A multiple-case SPECT study.2015

    • Author(s)
      Masamichi Ikawa, Tomoko Muramatsu, Katsuya Sugimoto, Akiko Matsunaga, Osamu Yamamura, Tadanori Hamano, Yasunari Nakamoto, Hidehiko Okazawa, Makoto Yoneda
    • Organizer
      The 67th Annual Meeting of American Academy of Neurology
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2015-04-18
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Book] 帯状回発作.てんかん用語集(第2版)2017

    • Author(s)
      米田誠
    • Total Pages
      166
    • Publisher
      診断と治療社
    • ISBN
      9784787823410
    • Related Report
      2017 Annual Research Report
  • [Book] Neuroimmunological Diseases2016

    • Author(s)
      Makoto Yoneda, Akiko Matsunaga, Masamichi Ikawa, Osamu Higuchi, Susumu Kusunoki,他
    • Total Pages
      292
    • Publisher
      Springer, NY, USA
    • Related Report
      2016 Research-status Report
  • [Book] EBMに基づく脳神経疾患の基本治療指針第4版2016

    • Author(s)
      米田誠,田村晃,松谷雅生,清水輝夫,辻貞俊,塩川芳昭,成田善孝,他
    • Total Pages
      807
    • Publisher
      メディカルビュー社,東京
    • Related Report
      2016 Research-status Report
  • [Book] 臨床神経内科学改定第6版2016

    • Author(s)
      米田誠,平山惠造,廣瀬源二郎,田代邦雄,葛原茂樹,他
    • Total Pages
      968
    • Publisher
      南山堂,東京
    • Related Report
      2016 Research-status Report
  • [Book] シリーズ《アクチュアル 脳・神経疾患の臨床》『免疫性神経疾患 病態と治療のすべて 』2016

    • Author(s)
      米田誠,南里和紀,大熊美咲,樋口理,辻省次,吉良潤一,他
    • Total Pages
      551
    • Publisher
      中山書店,東京
    • Related Report
      2016 Research-status Report
  • [Book] Hashimoto’s encephalopathy. In Neuroimmunological Diseases2016

    • Author(s)
      Makoto Yoneda, Akiko Matsunaga, Masamichi Ikawa
    • Publisher
      Springer
    • Related Report
      2015 Research-status Report
  • [Book] 橋本脳症.シリーズ《アクチュアル 脳・神経疾患の臨床》『免疫性神経疾患 病態と治療のすべて 』2016

    • Author(s)
      米田誠
    • Total Pages
      551
    • Publisher
      中山書店
    • Related Report
      2015 Research-status Report
  • [Book] 小脳失調症に免疫療法は有用か.シリーズ《アクチュアル 脳・神経疾患の臨床》『免疫性神経疾患 病態と治療のすべて 』2016

    • Author(s)
      南里和紀,大熊美咲,米田誠
    • Total Pages
      551
    • Publisher
      中山書店
    • Related Report
      2015 Research-status Report
  • [Book] SIADH,CPM,橋本脳症,感染と薬剤の両方が関与する脳炎,臨床神経内科学改定第6版2016

    • Author(s)
      米田誠
    • Total Pages
      968
    • Publisher
      南山堂
    • Related Report
      2015 Research-status Report
  • [Book] 甲状腺機能異常に伴う神経・筋障害EBMに基づく脳神経疾患の「基本治療指針第4版」2016

    • Author(s)
      米田誠
    • Total Pages
      807
    • Publisher
      メディカルビュー社
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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