| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
In this study, we examined the involvement of receptor for advanced glycation end products (RAGE) in hypothalamic-pituitary-adrenal axis.
In vivo, adrenal gland of Ager -/- mice was significantly heavier than that of Ager +/+ mice though without significant differences in body weight. Histological examination showed that RAGE was exclusively expressed in adrenocortical cells, and that adrenocortical cells in Ager -/- mice exhibited hypertrophic change as compared with those in Ager +/+ mice. The amount of corticosterone in 24-hour urine in Ager -/- mice was significantly less than that in Ager +/+ mice. Changes in serum corticosterone concentration following lipopolysaccharide (LPS) injection serum corticosterone concentration of Ager -/- mice were significantly lower than those of Ager +/+ mice. In vitro, RAGE expressed in adrenocortical cell appears to accelerate LPS-induced corticosterone production in mouse, where ERK 1/2 MAP kinase signaling may partly play a role.
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