| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
We have uncovered that high concentration of thyroglobulin accumulated in the follicular lumen of the thyroid has two distinct activity: one is to suppress gene expressions necessary for biosynthesis of thyroid hormone and iodine transport and the other is rather to enhance colloid resorption, hydrolysis, transport, and secretion. This evidence indicates that follicular thyroglobulin is the intrinsic autoregulator of thyroid hormone biosynthesis, its storage and secretion by negative-feedback mechanisms. It is speculated that gain-of-function of this mechanism will lead to hypothyroidisms and loss-of-function will induce hyperthyroidisms.
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