Targeting of bone marrow mesenchymal stromal/stem cells for the treatment of B cell acute lymphoblastic leukemia

• Project/Area Number: 15K09453
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: Kyoto University
• Principal Investigator: MIURA Yasuo 京都大学, 医学研究科, 助教 (70605146)
• Research Collaborator: IWASA Masaki 滋賀医科大学, 消化器血液内科, 大学院生 ; FUJISHIRO Aya 滋賀医科大学, 消化器血液内科, 大学院生 ; FUJII Sumie 京都大学, 血液・腫瘍内科, 大学院生
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 急性リンパ性白血病 / 間葉系間質細胞 / 抗がん剤抵抗性 / 細胞接着 / 骨髄微小環境 / 間葉系幹細胞 / ボルテゾミブ / 急性リンパ性白血病細胞 / 骨髄間葉系間質細胞

Outline of Final Research Achievements

Adult B cell acute lymphoblastic leukemia (B-ALL) belongs to an entity of intractable hematological diseases. In this study, we found that human B-ALL cells that adhered to human bone marrow mesenchymal stromal/stem cells (BM-MSC) showed resistance to anti-cancer drugs. Proteasome inhibitors interfered with the adhesion of B-ALL cells to BM-MSCs and subsequently restored chemosensitivity of B-ALL cells. In B-ALL mouse model, chemotherapy with bortezomib-containing anti-cancer drugs prolonged the survival of the mice. These findings suggest that pharmacological targeting of BM-MSCs is effective for the treatment of patients with B-ALL.

Research Products

• [Journal Article] Bortezomib interferes with adhesion of B cell precursor acute lymphoblastic leukemia cells through SPARC up-regulation in human bone marrow mesenchymal stromal/stem cells. (2017)
  • Author(s): Iwasa M, Miura Y, Fujishiro A, Fujii S, Sugino N, Yoshioka S, Yokota A, Hishita T, Hirai H, Andoh A, Ichinohe T, Maekawa T.
  • Journal Title: Int J Hematol. Volume: 105 Issue: 5 Pages: 587-597
  • DOI: 10.1007/s12185-016-2169-x
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Isolation of mesenchymal stromal/stem cells from cryopreserved umbilical cord blood cells (2017)
  • Author(s): Fujii S, Miura Y, Iwasa M, Yoshioka S, Fujishiro A, Sugino N, Kaneko H, Nakagawa Y, Hirai H, Takaori-Kondo A, Ichinohe T, Maekawa T.
  • Journal Title: Journal of Clinical and Experimental Hematopathology Volume: 57 Issue: 1 Pages: 1-8
  • DOI: 10.3960/jslrt.16019
  • NAID: 130005709558
  • ISSN: 1346-4280, 1880-9952
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Effects of acute exposure to low-dose radiation on the characteristics of human bone marrow mesenchymal stromal/stem cells (2017)
  • Author(s): Fujishiro Aya、Miura Yasuo、Iwasa Masaki、Fujii Sumie、Sugino Noriko、Andoh Akira、Hirai Hideyo、Maekawa Taira、Ichinohe Tatsuo
  • Journal Title: Inflamm Regen Volume: 37 Issue: 1 Pages: 1-12
  • DOI: 10.1186/s41232-017-0049-2
  • Peer Reviewed / Open Access
• [Journal Article] Graft-Versus-Host Disease Amelioration by Human Bone Marrow Mesenchymal Stromal/Stem Cell-Derived Extracellular Vesicles Is Associated with Peripheral Preservation of Naive T Cell Populations (2017)
  • Author(s): Fujii Sumie、Miura Yasuo、Fujishiro Aya、Shindo Takero、Shimazu Yutaka、Hirai Hideyo、Tahara Hidetoshi、Takaori-Kondo Akifumi、Ichinohe Tatsuo、Maekawa Taira
  • Journal Title: Stem Cells Volume: 36 Issue: 3 Pages: 434-445
  • DOI: 10.1002/stem.2759
  • NAID: 120006454670
  • Peer Reviewed / Open Access
• [Journal Article] ヒト間葉系幹細胞の基礎と臨床. (2017)
  • Author(s): 三浦康生
  • Journal Title: Clin Calcium. Volume: 27 Pages: 851-856
• [Journal Article] Pharmacological targeting of bone marrow mesenchymal stromal/stem cells for the treatment of hematological disorders. (2017)
  • Author(s): Sugino N, Ichinohe T, Takaori-Kondo A, Maekawa T, Miura Y.
  • Journal Title: Inflammation and Regeneration. Volume: - Issue: 1 Pages: 1-7
  • DOI: 10.1186/s41232-017-0038-5
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] ヒト骨髄間葉系幹細胞を用いた急性GVHDの治療 (2016)
  • Author(s): 三浦康生
  • Journal Title: 血液内科 Volume: 73 Pages: 410-415
  • NAID: 40020963587
• [Journal Article] Human mesenchymal stem cell therapy for acute graft versus host disease. (2016)
  • Author(s): Yoshioka S, Miura Y.
  • Journal Title: Translational Medicine Volume: 6 Issue: 3 Pages: 171-171
  • DOI: 10.4172/2161-1025.1000171
  • NAID: 120005980825
  • Peer Reviewed / Open Access
• [Journal Article] 生着の判定とキメリズム解析 (2016)
  • Author(s): 三浦康生
  • Journal Title: みんなに役立つ造血幹細胞移植の基礎と臨床. Ⅰ基礎編 第14章. 改訂3版 Volume: 3 Pages: 152-161
• [Journal Article] Genotyping of relapsing polychondritis identified novel susceptibility HLA alleles and distinct genetic characteristics from other rheumatic diseases. (2016)
  • Author(s): Terao C, Yoshifuji H, Yamano Y, Kojima H, Yurugi K, Miura Y, Maekawa T, Handa H, Ohmura K, Saji H, Mimori T, Matsuda F.
  • Journal Title: Rheumatology(Oxford) Volume: 55(9) Issue: 9 Pages: 1686-92
  • DOI: 10.1093/rheumatology/kew233
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Early osteoinductive human bone marrow mesenchymal stromal/stem cells support an enhanced hematopoietic cell expansion with altered chemotaxis- and adhesion-related gene expression profiles. (2016)
  • Author(s): Sugino N, #Miura Y, Yao H, Iwasa M, Fujishiro A, Fujii S, Hirai, Takaori-Kondo A, Ichinohe T, Maekawa T (#Corresponding author).
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 469 Issue: 4 Pages: 823-829
  • DOI: 10.1016/j.bbrc.2015.12.061
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Human bone marrow mesenchymal stromal/stem cells: current clinical applications and potential for hematology. (2016)
  • Author(s): Miura Y.
  • Journal Title: International Journal of Hematology Volume: 103 Issue: 2 Pages: 122-128
  • DOI: 10.1007/s12185-015-1920-z
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Guest editorial: Human mesenchymal stromal/stem cell (MSC). (2016)
  • Author(s): Miura Y.
  • Journal Title: International Journal of Hematology Volume: 103 Issue: 2 Pages: 119-121
  • DOI: 10.1007/s12185-015-1931-9
  • Peer Reviewed / Open Access
• [Journal Article] Human mesenchymal stromal/stem cell-mediated bone marrow organization. (2015)
  • Author(s): #Miura Y, Ichinohe T, Maekawa T (#Corresponding author).
  • Journal Title: Japanese Journal of Transfusion and Cell Therapy Volume: 61 Pages: 489-490
  • NAID: 130005103552
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Isolation of mesenchymal stromal/stem cells from small-volume umbilical cord blood units that do not qualify for the banking system. (2015)
  • Author(s): Yoshioka S, #Miura Y, Iwasa M, Fujishiro A, Yao H, Miura M, Fukuoka M, Nakagawa Y, Yokota A, Hirai H, Ichinohe T, Takaori-Kondo A, Maekawa T (#Corresponding author).
  • Journal Title: International Journal of Hematology Volume: 102 Issue: 2 Pages: 218-229
  • DOI: 10.1007/s12185-015-1828-7
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The role of growth differentiation factor 15 in the pathogenesis of primary myelofibrosis. (2015)
  • Author(s): Uchiyama T, Kawabata H, Miura Y, Yoshioka S, Iwasa M, Yao H, Sakamoto S, Fujimoto M, Haga H, Kadowaki N, Maekawa T, Takaori-Kondo A.
  • Journal Title: Cancer Medicine Volume: 4 Issue: 10 Pages: 1558-1572
  • DOI: 10.1002/cam4.502
  • NAID: 120005844250
  • Peer Reviewed / Open Access
• [Journal Article] Mesenchymal stromal/stem cellの基礎と臨床. (2015)
  • Author(s): 三浦康生.
  • Journal Title: 臨床血液 Volume: 56 Pages: 2195-2204
  • NAID: 130005103284
  • Peer Reviewed
• [Presentation] ヒト骨髄間葉系幹細胞由来細胞外小胞はナイーヴ制御性T細胞を保持し、急性移植片対宿主病を緩和する. (2018)
  • Author(s): 藤井紀恵，三浦康生，藤城綾，進藤岳郎，島津裕，平位秀世，高折晃史，一戸辰夫，前川平.
  • Organizer: 第40回日本造血細胞移植学会総会
• [Presentation] Perspectives of MSC-based clinical therapy. (2017)
  • Author(s): 三浦康生
  • Organizer: 第22回東海HSCT懇話会
  • Place of Presentation: 名古屋
  • Year and Date: 2017-03-10
  • Invited
• [Presentation] 臍帯血由来間葉系細胞 (2017)
  • Author(s): 三浦康生
  • Organizer: 第65回日本輸血・細胞治療学会総会 シンポジウム12「胎児組織由来間葉系細胞と新たな可能性」
  • Invited
• [Presentation] Effects of acute exposure to low-dose radiation on the characteristics of human bone marrow mesenchymal stromal/stem cells. (2017)
  • Author(s): Fujishiro A, Miura Y, Fujii S, Ichinohe T.
  • Organizer: The 1st International Symposium of the network-type Joint Usage/Research Center for Radio Disaster Medical Science
  • Int'l Joint Research
• [Presentation] Human bone marrow mesenchymal stromal/stem cell-derived extracellular vesicles ameliorate graft-versus-host disease-related manifestations. (2017)
  • Author(s): Fujii S, Miura Y, Fujishiro A, Shindo T, Shimazu Y, Hirai H, Takaori-Kondo A, Ichinohe T, Maekawa T.
  • Organizer: American Society of Hematology, 59th Annual Meeting
  • Int'l Joint Research
• [Presentation] 放射線照射が骨髄間葉系幹細胞の機能に与える影響の基礎的検討. (2017)
  • Author(s): 岩佐磨佐紀，三浦康生, 藤城綾，藤井紀恵，安藤朗，前川平，一戸辰夫.
  • Organizer: 第58回原子爆弾後遺症研究会
• [Presentation] CP-1/アルブミンを用いて凍結保存された，細胞数が少ないさい帯血ユニットからの間葉系幹細胞分離. (2017)
  • Author(s): 藤井紀恵，三浦康生，岩佐磨佐紀，吉岡聡，藤城綾，杉野典子，平位秀世，高折晃史，一戸辰夫，前川平.
  • Organizer: 第65回日本輸血・細胞治療学会総会
• [Presentation] Bortezomib contributes to the elimination of B-ALL cells through SPARC upregulation in BM-MSCs. (2017)
  • Author(s): Iwasa M, Miura Y, Fujishiro A, Fujii S, Sugino N, Yoshioka S, Hirai H, Andoh A, Ichinohe T, Maekawa T.
  • Organizer: The 79th Annual Meeting of the Japanese Society of Hematology
• [Presentation] Late Adherent Subpopulation in Umbilical Cord Blood Has the Same Characteristics and Hematopoiesis-Supporting Capacity As Mesenchymal Stromal/Stem Cells. (2016)
  • Author(s): Yoshioka S, Miura Y, Iwasa M, Fujishiro A, Sugino N, Fujii S, Nakagawa Y, Sato A, Yokota A, Hirai H, Ichinohe T, Takaori-Kondo A, Maekawa T.
  • Organizer: American Society of Hematology, 58th Annual Meeting
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2016-12-02
  • Int'l Joint Research
• [Presentation] C/EBPβ Is a Critical Regulator of CML Stem Cell Differentiation and Exhaustion Induced By Interferon-α. (2016)
  • Author(s): Yokota A, Hirai H, Hayashi Y, Sato R, Adachi H, Sato F, Sato A, Tamura A, Iwasa M, Fujishiro A, Shoji T, Kashiwagi T, Kamio N, Torikoshi Y, Miura Y, Nakano M, Tashiro K, Maekawa T.
  • Organizer: American Society of Hematology, 58th Annual Meeting
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2016-12-02
  • Int'l Joint Research
• [Presentation] C/EBPβ Is Required for Survival of Ly6C- Monocytes after Committment to Monocyte Lineage through Upregulation of Csf1r. (2016)
  • Author(s): Tamura A, Hirai H, Yokota A, Kamio N, Sato A, Shoji T, Kashiwagi T, Iwasa M, Fujishiro A, Miura Y, Maekawa T.
  • Organizer: American Society of Hematology, 58th Annual Meeting
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2016-12-02
  • Int'l Joint Research
• [Presentation] ヒト間葉系幹細胞の造血幹細胞移植への応用. (2016)
  • Author(s): 三浦康生
  • Organizer: 第15回京阪神輸血・免疫・血液研究会
  • Place of Presentation: 大阪
  • Year and Date: 2016-10-29
  • Invited
• [Presentation] ヒト間葉系幹細胞. (2016)
  • Author(s): 三浦康生
  • Organizer: 第36回セルセラピーセミナー
  • Place of Presentation: 高崎，群馬
  • Year and Date: 2016-10-28
  • Invited
• [Presentation] ヒト骨髄間葉系幹細胞は免疫調節薬による造血幹前駆細胞の分化に影響を及ぼす. (2016)
  • Author(s): 藤井紀恵，三浦康生，岩佐磨佐紀，藤城綾，杉野典子，平位秀世，高折晃史，一戸辰夫，前川平.
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-06
• [Presentation] The C/EBPβ transcription factor promotes exhaustion of CML stem cells in response to interferon-α. (2016)
  • Author(s): Yokota A, Hirai H, Hayashi Y, Sato R, Adachi H, Sato F, Sato A, Tamura A, Miura Y, Nakano M, Tashiro K, Maekawa T.
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-06
• [Presentation] The C/EBPβ Transcription Factor Mediates the Effect of IFNα on CML Stem Cells Through Promoting Their Differentiation and Exhaustion. (2016)
  • Author(s): Yokota A, Hirai H, Hayashi Y, Sato R, Adachi H, Sato F, Sato A, Tamura A, Iwasa M, Fujishiro A, Shoji T, Kashiwagi T, Miura Y, Nakano M, Tashiro K, Maekawa T.
  • Organizer: The 5th JCA-AACR Special Joint Conference
  • Place of Presentation: Urayasu, Chiba, Japan
  • Year and Date: 2016-07-14
  • Int'l Joint Research
• [Presentation] ヒト間葉系幹細胞を標的とした難治性造血器悪性疾患治療. (2016)
  • Author(s): 三浦康生
  • Organizer: 第8回播磨血液疾患・輸血療法研究会
  • Place of Presentation: 姫路，兵庫
  • Year and Date: 2016-06-29
  • Invited
• [Presentation] ヒト間葉系幹細胞を標的とした難治性造血器悪性疾患治療. (2016)
  • Author(s): 三浦康生
  • Organizer: 第37回日本炎症・再生医学会 シンポジウム5「組織幹細胞治療と炎症」
  • Place of Presentation: 京都
  • Year and Date: 2016-06-16
  • Invited
• [Presentation] 間葉系幹細胞の急性GVHDに対する治療効果のメカニズム解析. (2016)
  • Author(s): 藤井紀恵，三浦康生，藤城綾，岩佐磨佐紀，杉野典子，高折晃史，一戸辰夫，前川平．
  • Organizer: 第47回京都造血幹細胞移植研究会
  • Place of Presentation: 京都
  • Year and Date: 2016-06-10
• [Presentation] Mesenchymal stromal/stem cellの基礎と臨床. (2016)
  • Author(s): 三浦康生
  • Organizer: 第45回福島造血幹細胞移植治療研究会
  • Place of Presentation: 福島
  • Year and Date: 2016-04-16
  • Invited
• [Presentation] ヒト間葉系幹細胞の特性に基づいた治療への応用の可能性. (2016)
  • Author(s): 三浦康生
  • Organizer: 第64回日本輸血・細胞治療学会総会 シンポジウム6 間葉系幹細胞を用いた細胞治療＜細胞治療サイエンス・フォーラム＞
  • Place of Presentation: 京都
  • Year and Date: 2016-04-09
  • Invited
• [Presentation] さい帯血バンクの保存基準に満たない少容量さい帯血からの間葉系幹細胞の分離 [Abstract #O2-3]. (2016)
  • Author(s): 吉岡聡，三浦康生，岩佐磨佐紀，藤城綾，藤井紀恵，杉野典子，平位秀世，一戸辰夫，高折晃史，前川平.
  • Organizer: 第38回日本造血細胞移植学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2016-03-03
• [Presentation] Human bone marrow mesenchymal stromal/sem cells modulate IMiDs-induced differentiation of HSPCs. (2016)
  • Author(s): Fujii S, Miura Y, Iwasa M, Fujishiro A, Sugino N, Sato A, Yokota A, Hirai H, Takaori-Kondo A, Ichinohe T, Maekawa T.
  • Organizer: The 78th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: 横浜
• [Presentation] Vitamin K2 supports hematopoiesis through acting on human bone marrow mesenchymal stromal/stem cells. (2016)
  • Author(s): Fujishiro A, Miura Y, Iwasa M, Fujii S, Sugino N, Sato A, Yokota A, Hirai H, Andoh A, Tohyama K, Ichinohe T, Maekawa T.
  • Organizer: The 78th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: 横浜
• [Presentation] The C/EBPβ transcription factor mediates exhaustion of CML stem cells induced by IFNα. (2016)
  • Author(s): Yokota A, Hirai H, Sato A, Tamura A, Shoji T, Kashiwagi T, Fujishiro A, Iwasa M, Miura Y, Hayashi Y, Maekawa T.
  • Organizer: The 78th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: 横浜
• [Presentation] Stress-induced translational alteration of C/EBPβ isoforms regulates the behavior og HSPCs. (2016)
  • Author(s): Sato A, Hirai H, Yokota A, Tamura A, Shoji T, Kashiwagi T, Iwasa M, Fujishiro A, Miura Y, Maekawa T.
  • Organizer: The 78th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: 横浜
• [Presentation] Bortezomib Attenuates Adhesion of B Cell Precursor Acute Lymphoblastic Leukemia Cells to Bone Marrow Mesenchymal Stromal/Stem Cells Via Regulating SPARC Expression [Abstract #786] [Oral presentation] [Abstract Achievement Award]. (2015)
  • Author(s): Iwasa M, Miura Y, Fujishiro A, Fujii S, Sugino N, Tamura A, Sato A, Yokota A, Yoshioka S, Kito K, Ando A, Hirai H, Takaori-Kondo A, Ichinohe T, Maekawa T.
  • Organizer: American Society of Hematology, 57th Annual Meeting
  • Place of Presentation: Orlando, FL, USA
  • Year and Date: 2015-12-05
  • Int'l Joint Research
• [Presentation] Vitamin K2 Supports Hematopoiesis through Acting on Bone Marrow Mesenchymal Stromal/Stem Cells [Abstract #1192]. (2015)
  • Author(s): Fujishiro A, Miura Y, Iwasa M, Fujii S, Tamura A, Sato A, Yokota A, Sugino N, Hirai H, Ando A, Takaori-Kondo A, Ichinohe T, Maekawa T.
  • Organizer: American Society of Hematology, 57th Annual Meeting
  • Place of Presentation: Orlando, FL, USA
  • Year and Date: 2015-12-05
  • Int'l Joint Research
• [Presentation] Mesenchymal stromal/stem cellの基礎と臨床 [Abstract #EL-7]. (2015)
  • Author(s): 三浦康生.
  • Organizer: 第77回日本血液学会総会
  • Place of Presentation: 金沢
  • Year and Date: 2015-10-16
  • Invited
• [Presentation] Effects of low-dose irradiation on human bone marrow mesenchymal stromal/stem cells [Abstract #PS-2-167]. (2015)
  • Author(s): Fujishiro A, Miura Y, Iwasa M, Tamura A, Sato A, Yokota A, Hirai H, Ando A, Maekawa T, Ichinohe T.
  • Organizer: The 76th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: Kanazawa, Japan
  • Year and Date: 2015-10-16
• [Presentation] ボルテゾミブは前駆B細胞性白血病細胞の骨髄間葉系幹細胞への接着を減弱させる [Abstract #P-3228]. (2015)
  • Author(s): 岩佐磨佐紀、三浦康生、藤城綾、杉野典子、佐藤淳至、田村彰広、横田明日美、木藤克之、平位秀世、安藤朗、高折晃史、一戸辰夫、前川平.
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] 放射線被ばくが骨髄由来間葉系幹細胞の機能に与える影響. (2015)
  • Author(s): 一戸辰夫, 大島久美, 岩佐磨佐紀, 藤城綾, 三浦康生, 前川平.
  • Organizer: 平成27年度広島大学・長崎大学連携研究カンファレンス
  • Place of Presentation: 広島
  • Year and Date: 2015-06-06
• [Presentation] 凍結保存されたさい帯血ユニットからの間葉系幹細胞分離の検討 [優秀演題賞]. (2015)
  • Author(s): 岩佐磨佐紀, 三浦康生, 藤城綾, 吉岡聡, 木藤克之, 安藤朗, 平位秀世, 一戸辰夫, 前川平.
  • Organizer: 第23回近畿臍帯血幹細胞移植研究会
  • Place of Presentation: 大阪
  • Year and Date: 2015-05-09
• [Presentation] 間葉系幹細胞を標的とした急性リンパ芽球性白血病の治療戦略の基礎検討. (2015)
  • Author(s): 岩佐磨佐紀, 三浦康生, 藤城綾, 杉野典子, 木藤克之, 平位秀世, 安藤明, 一戸辰夫, 高折晃史, 前川平.
  • Organizer: KYOTO BASIC SCIENCE FORUM
  • Place of Presentation: 京都
  • Year and Date: 2015-04-24
• [Remarks] 京都大学 教育研究活動データベース
  • URL: https://kyouindb.iimc.kyoto-u.ac.jp/j/rI5bL
• [Remarks] 文部科学省科学研究費新学術領域研究 平成27年度 がん研究分野の特性等を踏まえた支援活動
  • URL: http://ganshien.umin.jp/research/main/maekawa/05.html
• [Remarks] 三浦 康生 - 京都大学 教育研究活動データベース
  • URL: https://kyouindb.iimc.kyoto-u.ac.jp/j/rI5bL
• [Remarks] 三浦康生ー平成27年度 がん研究分野の特性等を踏まえた支援活動
  • URL: http://ganshien.umin.jp/research/main/maekawa/05.html
• [Remarks] 京都大学医学部附属病院 輸血細胞治療部 ホームページ
  • URL: http://dtm.kuhp.kyoto-u.ac.jp/staff