microRNA in nascent platelet
Project/Area Number |
15K09458
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Hematology
|
Research Institution | Iwate Medical University |
Principal Investigator |
Kowata Shugo 岩手医科大学, 医学部, 講師 (30418884)
|
Co-Investigator(Kenkyū-buntansha) |
石田 陽治 岩手医科大学, 医学部, 助教授 (70151389)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
Keywords | 新生血小板 / Autophagy / microRNA / 細胞内小器官 / miRNA / 血小板産生 / 血小板減少症 / 特発性血小板減少性紫斑病 |
Outline of Final Research Achievements |
Murine thrombocytopenia model showed that nascent platelets contained specific microRNAs. ROS triggered autophagy flux at megakaryocytic and nascent platelets, and autophagy regulated adequate distribution of cellular organelle and microRNAs in individual platelets. In human specimens, the ratio of autophagosome and RNA positive platelets were significant higher in immune thrombocytopenia. However, the ratio of autophagosome and microRNA positive platelets were significant lower in patients with myelodysplastic syndrome and aplastic anemia. Autophagy in nascent platelets may guarantee a quality of individual platelets via regulation of adequate distribution of cellular organelle and microRNAs in individual platelets.
|
Report
(4 results)
Research Products
(18 results)