| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
Murine thrombocytopenia model showed that nascent platelets contained specific microRNAs. ROS triggered autophagy flux at megakaryocytic and nascent platelets, and autophagy regulated adequate distribution of cellular organelle and microRNAs in individual platelets. In human specimens, the ratio of autophagosome and RNA positive platelets were significant higher in immune thrombocytopenia. However, the ratio of autophagosome and microRNA positive platelets were significant lower in patients with myelodysplastic syndrome and aplastic anemia. Autophagy in nascent platelets may guarantee a quality of individual platelets via regulation of adequate distribution of cellular organelle and microRNAs in individual platelets.
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