Function of APOBEC3 in EBV-positive T or NK-cell lymphoproliferative diseases

• Project/Area Number: 15K09468
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: ARAI Ayako 東京医科歯科大学, 大学院保健衛生学研究科, 准教授 (70359678)
• Co-Investigator(Kenkyū-buntansha): 今留 謙一 国立研究開発法人国立成育医療研究センター, 高度感染症診断部, 部長 (70392488)
• Co-Investigator(Renkei-kenkyūsha): OHARA Osamu 公益財団法人かずさDNA研究所, ゲノム医療推進部, 部長 (20370926)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: EBV陽性T,NKリンパ増殖症 / EBウイルス / NF-ｋB / bortezomib / APOBEC3B / NF-kB / EBV陽性T、NK細胞リンパ増殖症 / Epstein-Barr Virus / NF-κB / Bortezomib / P糖蛋白

Outline of Final Research Achievements

Chronic active EBV infection (CAEBV) is a neoplasm of EBV-infected T- or NK-cells. It was newly defined as a disorder including conventional CAEBV, severe mosquito bite allergy, and hydroa vacciniforme-like lymphoproliferative disorder according to the WHO classification of lymphoid neoplasms revised in 2017. CAEBV is resistant to chemotherapies, and the only curative treatment strategy thus far has been hematopoietic stem cell transplantation. We found that APOBEC3B expression was increased in the EBV-positive T- or NK-cell lines cells from patients of CAEBV, one of EBV-positive T or NK-cell lymphoproliferative diseases. A proteasome inhibitor, bortezomib suppressed APOBEC3B expression in these cells and inhibited proliferation and cytokine production in these cells. In addition, bortezomib administration decreased EBV-DNA load in the peripheral blood of CAEBV xenograft models. Based on the results, we started an investigator-initiated clinical research of bortezomib for CAEBV.

Research Products

• [Journal Article] EBV induces persistent NF-κB activation and contributes to survival of EBV-positive neoplasmtic T- or NK-cells. (2017)
  • Author(s): Imadome K*., Takada H*. , Shibayama H., Yoshimori M., Wang L., Saitoh Y., Uota S., Yamaoka S., Koyama T., Shimizu N., Yamamoto K., Fujiwara S., Miura O., Arai A.
  • Journal Title: PLoS One. Volume: 12(3) Issue: 3 Pages: e0174136-e0174136
  • DOI: 10.1371/journal.pone.0174136
  • Peer Reviewed / Open Access
• [Journal Article] Development of Extranodal NK/T-cell Lymphoma Nasal Type in Cerebrum Following Epstein-Barr Virus-positive Uveitis (2017)
  • Author(s): Imai A, Takase H, Imadome KI, Matsuda G, Ohnishi I, Yamamoto K, Kudo K, Tanaka Y, Maehara T, Miura O, Arai A.
  • Journal Title: Internal Medicine Volume: 56 Issue: 11 Pages: 1409-1414
  • DOI: 10.2169/internalmedicine.56.7573
  • NAID: 130006857222
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] Common Variable Immunodeficiency Caused by FANC Mutations (2017)
  • Author(s): Sekinaka Y., Mitsuiki N., Imai K., Yabe M., Yabe H., Mitsui-Sekinaka K., Honma K., Takagi M., Arai A., Yoshida K., Okuno Y., Shiraishi Y., Chiba K., Tanaka H., Miyano S., Muramatsu H., Kojima S., Hira A., Takata M., Ohara O., Ogawa S., Morio T., Nonoyama S.
  • Journal Title: Journal of clinical immunology Volume: 37 Issue: 5 Pages: 434-444
  • DOI: 10.1007/s10875-017-0396-4
  • Peer Reviewed / Open Access
• [Journal Article] Pathogenesis and FDG-PET/CT findings of Epstein?Barr virus-related lymphoid neoplasms (2017)
  • Author(s): Toriihara A, Nakajima R, Arai A, Nakadate M, Abe K, Kubota K, Tateishi U
  • Journal Title: Annals of Nuclear Medicine Volume: 31 Issue: 6 Pages: 425-436
  • DOI: 10.1007/s12149-017-1180-5
  • Peer Reviewed
• [Journal Article] Inflammatory cytokine production in chronic active Epstein-Barr virus infection (2017)
  • Author(s): 小野澤 枝里香、柴山 春奈、今留 謙一、廿楽 明穂、小山 高敏、三浦 修、新井 文子
  • Journal Title: Rinsho Ketsueki Volume: 58 Issue: 3 Pages: 189-196
  • DOI: 10.11406/rinketsu.58.189
  • NAID: 130005549392
  • ISSN: 0485-1439, 1882-0824
  • Peer Reviewed
• [Journal Article] Virus-specific cytotoxic T cells in chronic active Epstein-Barr virus infection (2017)
  • Author(s): 柴山 春奈、今留 謙一、小野澤 枝里香、廿楽 明穂、三浦 修、小山 高敏、新井 文子
  • Journal Title: Rinsho Ketsueki Volume: 58 Issue: 6 Pages: 583-588
  • DOI: 10.11406/rinketsu.58.583
  • NAID: 130005709602
  • ISSN: 0485-1439, 1882-0824
  • Peer Reviewed
• [Journal Article] FDG-PET/CT findings of chronic active Epstein?Barr virus infection (2017)
  • Author(s): Torihara A, Arai A. Nakadate M, Yamamoto K, Imadome K, Miura O, Tateish U
  • Journal Title: Leukemia & Lymphoma Volume: 12 Issue: 6 Pages: 1-4
  • DOI: 10.1080/10428194.2017.1387902
  • Peer Reviewed
• [Journal Article] Chronic active Epstein-Barr virus infection with cutaneous lymphoproliferation: haemophagocytosis in the skin and haemophagocytic syndrome (2017)
  • Author(s): Tokoro S.、Namiki T.、Miura K.、Watanabe K.、Arai A.、Imadome K.、Yokozeki H.
  • Journal Title: Journal of the European Academy of Dermatology and Venereology Volume: 32 Issue: 3
  • DOI: 10.1111/jdv.14640
  • Peer Reviewed
• [Journal Article] Effective therapy with infliximab for clinically mild encephalitis/encephalopathy with a reversible splenial lesion in an infant with Kawasaki disease (2017)
  • Author(s): Kurokawa Y, Masuda H, Kobayashi T, Ono H, Kato H, Imadome KI, Abe J, Abe Y, Ito S, Ishiguro A
  • Journal Title: Japanese Journal of Clinical Immunology Volume: 40 Issue: 3 Pages: 190-195
  • DOI: 10.2177/jsci.40.190
  • NAID: 130005865101
  • ISSN: 0911-4300, 1349-7413
  • Peer Reviewed
• [Journal Article] A Rho-associated coiled-coil containing kinases (ROCK) inhibitor, Y-27632, enhances adhesion, viability and differentiation of human term placenta-derived trophoblasts in vitro (2017)
  • Author(s): Kenichiro Motomura, Naoko Okada, Hideaki Morita, Mariko Hara, Masato Tamari, Keisuke Orimo, Go Matsuda, Ken-Ichi Imadome, Akio Matsuda, Takeshi Nagamatsu, Mikiya Fujieda, Haruhiko Sago, Hirohisa Saito, and Kenji Matsumoto
  • Journal Title: PLOS ONE Volume: in press Issue: 5 Pages: e0177994-e0177994
  • DOI: 10.1371/journal.pone.0177994
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] An Epstein-Barr virus susceptible immature T-cell line, WILL4, established from a patient with T-lymphoblastic lymphoma bearing CD21 and a clonal EBV genome (2017)
  • Author(s): Hosoi H, Imadome KI, Tamura S, Kuriyama K, Murata S, Yamashita Y, Mushino T, Oiwa T, Kobata H, Nishikawa A, Nakakuma H, Hanaoka N, Isobe Y, Ohshima K, Sonoki T
  • Journal Title: Leukemia Research Volume: 55 Pages: 1-5
  • DOI: 10.1016/j.leukres.2017.01.022
  • Peer Reviewed
• [Journal Article] Clinically Mild Encephalitis/Encephalopathy With a Reversible Splenial Lesion Accompanied by Epstein-Barr Virus Hemophagocytic Lymphohistiocytosis: A Case Report and Review of the Literature. (2017)
  • Author(s): Yamaguchi H., Ishida T., Yokoi T., Tanaka T., Maruyama A., Nagase H., Hasegawa D., Imadome K., Takeda H., Kosaka Y., Uetani Y.
  • Journal Title: J Pediatr Hematol Oncol. Volume: 39(2) Issue: 2 Pages: 92-96
  • DOI: 10.1097/mph.0000000000000708
  • Peer Reviewed / Open Access
• [Journal Article] Generation and Analysis of Humanized Mouse Model of EBV Infection (2017)
  • Author(s): Imadome KI, Fujiwara S.
  • Journal Title: Methods Mol Biol Volume: 1532 Pages: 241-254
  • DOI: 10.1007/978-1-4939-6655-4_18
  • ISBN: 9781493966530, 9781493966554
  • Peer Reviewed
• [Journal Article] Transmission of chromosomally integrated humanherpesvisus 6 via cord blood transplantation. (2017)
  • Author(s): Yamada Y., Osumi T., Imadome K., Takahashi E., Ohye T., Yoshikawa T., Tomizawa D., Kato M., Matsumoto K.
  • Journal Title: Transpl Infect Dis. Volume: 19(1) Issue: 1 Pages: 1-4
  • DOI: 10.1111/tid.12636
  • Peer Reviewed
• [Journal Article] Achievement of disease control with donor-derived EB virus-specific cytotoxic T cells after allogeneic peripheral blood stem cell transplantation for aggressive NK-cell leukemia (2017)
  • Author(s): Haji S, Shiratsuchi M, Matsushima T, Takamatsu A, Tsuda M, Tsukamoto Y, Tanaka E, Ohno H, Fujioka E, Ishikawa Y, Imadome KI, Ogawa Y.
  • Journal Title: International Journal of Hematology Volume: 105 Issue: 4 Pages: 540-544
  • DOI: 10.1007/s12185-016-2131-y
  • Peer Reviewed
• [Journal Article] Hematopoietic stem cell transplantation for adults with EBV-positive T- or NK- cell lymphoproliferative disorders: efficacy and predictive markers. (2016)
  • Author(s): Arai A., Sakashita C., Hirose C., Imadome K., Yamamoto M., Jinta M., Fujiwara S., Tomita M., Shimizu N., Morio T., Miura O.
  • Journal Title: Bone Marrow Transplant. Volume: 22 Issue: 6 Pages: 879-82
  • DOI: 10.1038/bmt.2016.3
  • Peer Reviewed / Open Access
• [Journal Article] High-dose methotrexate following intravitreal methotrexate administration in preventing central nervous system involvement of primary intraocular lymphoma. (2016)
  • Author(s): Akiyama H, Takase H, Kubo F, Miki T, Yamamoto M, Tomita M, Mochizuki M, Miura O, Arai A.
  • Journal Title: Cancer Sci. Volume: 107 Issue: 10 Pages: 1458-1464
  • DOI: 10.1111/cas.13012
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Epstein-Barr Virus-positive T-cell Lymphoproliferative Disease Following Umbilical Cord Blood Transplantation for Acute Myeloid Leukemia (2016)
  • Author(s): Yui S., Yamaguchi H., Imadome K., Arai A., Takahashi M., Ohashi R., Asayama T., Kondo A., Moriya K., Nakayama K., Dan K., Shimizu S., Inokuchi K.
  • Journal Title: Journal of Nippon Medical School Volume: 83 Issue: 1 Pages: 35-42
  • DOI: 10.1272/jnms.83.35
  • NAID: 130005132782
  • ISSN: 1345-4676, 1347-3409
  • Peer Reviewed / Open Access
• [Journal Article] MLL-AF9遺伝子転座を伴う難治性の乳房原発骨髄肉腫 (2016)
  • Author(s): 内田 慧美, 渡邉 健, 押川 学, 坂下 千瑞子, 黒須 哲也, 福田 哲也, 新井 文子, 村上 直巳, 三浦 修, 山本 正英.
  • Journal Title: 臨床血液 Volume: 57 Pages: 47-51
  • NAID: 130005125837
  • Peer Reviewed
• [Journal Article] Long-term outcome of patients with acquired chronic pure red cell aplasia (PRCA) following immunosuppressive therapy: a final report of the nationwide cohort study in 2004/2006 by the Japan PRCA collaborative study group. (2015)
  • Author(s): Hirokawa M, Sawada K, Fujishima N, Teramura M, Bessho M, Dan K, Tsurumi H, Nakao S, Urabe A, Fujisawa S, Yonemura Y, Kawano F, Oshimi K, Sugimoto K, Matsuda A, Karasawa M, Arai A, Komatsu N, Harigae H, Omine M, Ozawa K, Kurokawa M; PRCA Collaborative Study Group.
  • Journal Title: Br J Haematol. Volume: in press Issue: 6 Pages: 879-886
  • DOI: 10.1111/bjh.13376
  • Peer Reviewed / Open Access
• [Journal Article] P-glycoprotein is expressed and causes resistance to chemotherapy in EBV-positive T-cell lymphoproliferative diseases (2015)
  • Author(s): Yoshimori M, Takada H, Imadome K, Kurata M, Yamamoto K, Koyama T, Shimizu N, Fujiwara S, Miura O and Arai A
  • Journal Title: Cancer medicine Volume: 4 Issue: 10 Pages: 1494-1504
  • DOI: 10.1002/cam4.494
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Efficacy and safety of bortezomib-containing induction chemotherapy for autologous stem cell transplantation-eligible Japanese multiple myeloma patients -A phase 2 multicenter trial- (2015)
  • Author(s): Kudo D, Ohashi K, Komeno K, Nakamura Y, Shinagawa A, Yoshida C, Katsura Y, Ota I, Kakihana K, Kobayashi T, Kawai N, Kato A, Arai A, Yamamoto K, Toyota S, Kumagai T, Ohwada A, Miki T, Hori M, Okoshi Y, Kojima H, and Sakamaki H
  • Journal Title: International Journal of Myeloma Volume: 5 Pages: 12-22
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] L-Asparaginase monotherapy for EBV-positive T/NK lymphoproliferative diseases: A pilot Study (2015)
  • Author(s): Jinta M, Imadome K, Komatsu H, Yoshimori M, Kurata M, Fujiwara S, Miura O, Arai A.
  • Journal Title: Journal of Medical and Dental Sciences Volume: 62 Issue: 1 Pages: 1-9
  • DOI: 10.11480/620101
  • NAID: 110009889970
  • ISSN: 1342-8810, 2185-9132
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 中枢神経リンパ腫に対するbusulfanを含む前処置を用いた自家末梢血幹細胞移植の検討 (2017)
  • Author(s): 山下知子, 水地大輔, 吉藤康太, 田中圭祐, 野上彩子, 渡邊健, 坂下千瑞子, 福田哲也, 新井文子, 川又紀彦, 三浦修, 山本正英
  • Organizer: 第39回日本造血細胞移植学会総会
• [Presentation] 若年成人T細胞性急性リンパ性白血病に対するL-asparaginase投与に伴う超高トリグリセリド血症 (2017)
  • Author(s): 酒井伸, 吉藤康太, 齋藤達也, 山下知子, 野上彩子, 渡邉健, 新井文子 ,川又紀彦 三浦修
  • Organizer: 日本内科学会関東地方会
• [Presentation] 慢性活動性EBウイルス感染症におけるEBV特異的細胞傷害性T細胞 (2017)
  • Author(s): 柴山 春奈，今留 謙一，小野澤 枝里香，廿楽 明穂，三浦 修，小山 高敏，新井 文子
  • Organizer: 第26回EBウイルス感染症研究会
• [Presentation] 性活動性EBウイルス感染症における炎症性サイトカインの産生の解析 (2017)
  • Author(s): 小野澤枝里香、柴山春奈、今留謙一、廿楽明穂、小山高敏、三浦修、新井文子
  • Organizer: 第26回EBウイルス感染症研究会
• [Presentation] 腫瘍随伴性天疱瘡と閉塞性細気管支炎を合併した濾胞性リンパ腫の 1 例. (2017)
  • Author(s): 渡邉 健，吉藤 康太，齋藤 達也，山下 知子，野上 彩子，山本 正英，坂下 千瑞子, 福田 哲也，新井 文子，東田 修二，川又 紀彦，三浦 修
  • Organizer: 第4回日本血液学会関東甲信越地方会
• [Presentation] EBウイルス陽性T,NK細胞培養上清は単球系細胞のマクロファージへの分化とサイトカイン産生を誘導する. (2017)
  • Author(s): 廿楽明穂、吉森真由美、小野澤枝里香、今留謙一、大川龍之介、戸塚実、三浦修、小山高敏、新井文子
  • Organizer: 第4回日本血液学会関東甲信越地方会
• [Presentation] Epstein-Barrウイルス陽性T,NK細胞培養上清は単球系細胞のマクロファージへの分化を誘導する (2017)
  • Author(s): 今野夏乃子、廿楽明穂、吉森真由美、小野澤枝里香、今留謙一、大川龍之介、戸塚実、新井文子
  • Organizer: 第12回 日本臨床検査学教育学会学術大会
• [Presentation] 慢性活動性Epstein-Barrウイルス感染症 ～炎症と腫瘍、2つの顔を持つ疾患～. (2017)
  • Author(s): 新井文子
  • Organizer: 第45回日本臨床免疫学会総会ワークショップ慢性炎症と免疫不全
  • Invited
• [Presentation] 慢性活動性EBウイルス感染症の本邦における診療実態の全国調査 (2017)
  • Author(s): 米瀬 一朗、坂下 千瑞子、今留 謙一、小林 徹、澤田 明久、伊藤 嘉規, 福原 規子、廣瀬朝生、竹田 勇輔、牧田雅典、遠藤 知之、木村 俊一、石村 匡崇、冨田 誠、中村 桂子、三浦 修、大賀正一、木村宏、藤原 成悦、新井 文子
  • Organizer: 第79回日本血液学会総会
• [Presentation] 慢性活動性EBウイルス感染症におけるAPOBEC3Bの発現亢進 (2017)
  • Author(s): 廿楽明穂、今留謙一、大内史彦、柴山春奈、小原収、今井耕輔、松田剛、小野澤枝里香、吉森真由美、小山高敏、三浦修、新井文子
  • Organizer: 第79回日本血液学会総会
• [Presentation] 慢性活動性Epstein-Barrウイルス感染症ではSTAT3が恒常的に活性化し治療標的となりうる (2017)
  • Author(s): 小野澤枝里香、柴山春奈、高田穂菜実、今留謙一、青木奨、吉森真由美、藤原成悦、小山高敏、三浦修、新井文子
  • Organizer: 第79回日本血液学会総会
• [Presentation] Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma with 11q Deletion (2017)
  • Author(s): Yamashita T, Tsutsumi H, Yoshifuji K, Saito T, Umezawa Y, Nogami A, Watanabe K, Nagao T, Sakashita C, Yamamoto M, Arai A, Kawamata N, Miura O, Fukuda T
  • Organizer: 第79回日本血液学会学術集会
• [Presentation] 定量ストリップ法によるEpstein-Barr virus DNA測定法の開発 (2017)
  • Author(s): 吉森真由美、今留謙一、新井文子、川野布由子、石川百合子、高橋絵都子、和田尚美、湯之前雄太、外丸靖浩、清水則夫
  • Organizer: 第64回日本臨床検査医学会学術集会
• [Presentation] STAT3 is constitutively activated and can be a therapeutic target of JAK inhibitors in chronic active Epstein-Barr virus infection (2017)
  • Author(s): Onozawa E, Shibayama H, Aoki S, Tuzura A, Imadome K, Koyama K, Miura O, Arai A.
  • Organizer: The 22th Congress of European society of Hematology
  • Int'l Joint Research
• [Presentation] Tumor Cells from EBV-Positive T- or NK-Cell Neoplasms Induce Differentiation and Activation of Macrophages by Secreting Humoral Factors (2017)
  • Author(s): Tsuzura A, Yoshimori M, Konno K, Imadome K, Onozawa E, Ohkawa R, Tozuka M, Miura O, Arai A
  • Organizer: The 49th American Society of Hematology Annual Meeting
  • Int'l Joint Research
• [Presentation] 術前診断が困難であった右後頭葉の節外性NK/T細胞リンパ腫の一例 (2016)
  • Author(s): 足立拓也、鳥井原彰、大山潤、立石宇貴秀、新井文子、工藤琢巳、高瀬博、大西威一郎
  • Organizer: 第449回 日本医学放射線学会
  • Place of Presentation: 東京都文京区
  • Year and Date: 2016-12-10
• [Presentation] In vitro and in vivo effects of proteasome inhibitor bortezomib on Epstein-Barr virus-positive T- or NK-cell lymphoproliferative diseases. (2016)
  • Author(s): Haruna Shibayama, Ken-ichi Imadome, Chizuko Sakashita, Ken Watanabe, Norio Shimizu, Takatoshi Koyama, Shigeyoshi Fujiwara, Osamu Miura, Ayako Arai.
  • Organizer: 第78回日本血液学会総会.
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2016-10-14
• [Presentation] Common variable immunodeficiency caused by FANC mutations. (2016)
  • Author(s): Yujin Sekinaka, Noriko Mitsuiki, Kohsuke Imai, Miharu Yabe, Hiromasa Yabe, Masatoshi Takagi, Ayako Arai, Kenichi Yoshida, Yusuke Okuno, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Seiji Kojima, Asuka Hira, Minoru Takata, Osamu Ohara, Seishi Ogawa, Tomohiro Morio, and Shigeaki Nonoyama.
  • Organizer: .17th Biennial Meeting of European Society for Immunodeficiencie.
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2016-09-21
  • Int'l Joint Research
• [Presentation] 再発・難治性マントル細胞リンパ腫(MCL)を対象とした経口フルダラビンとリツキシマブ併用(FR)療法の多施設共同臨床第Ⅱ相試験（造血器腫瘍研究会FR-MCL試験） (2016)
  • Author(s): 小椋美知則、鈴木律朗、前田義治、塚本憲史、薄井紀子、大間知謙、新井文子、薬師神芳洋、堀田知光、木下朝博、
  • Organizer: 第56回日本リンパ網内系学会総会.
  • Place of Presentation: 熊本県熊本市
  • Year and Date: 2016-09-01
• [Presentation] In vitro and in vivo effects of proteasome inhibitor bortezomib on Epstein-Barr virus-positive T- or NK-cell lymphoproliferative diseases. (2016)
  • Author(s): Haruna Shibayama, Ken-ichi Imadome, Chizuko Sakashita, Ken Watanabe, Norio Shimizu, Takatoshi Koyama, Shigeyoshi Fujiwara, Osamu Miura, Ayako Arai
  • Organizer: 17th International Symposium on EBV and associated diseases.
  • Place of Presentation: Zurich, Switzerland
  • Year and Date: 2016-08-08
  • Int'l Joint Research
• [Presentation] 慢性活動性EBウイルス感染症における炎症性サイトカインの産生の解析. (2016)
  • Author(s): 小野澤枝里香、柴山春奈、今留謙一、廿楽明穂、青木奨、小山高敏、三浦修、新井文子.
  • Organizer: 第13回EBウイルス研究会.
  • Place of Presentation: 東京都港区
  • Year and Date: 2016-07-09
• [Presentation] 蚊刺過敏症で発症しT細胞リンパ腫へ進展したEBウイルス陽性Tリンパ増殖症. (2016)
  • Author(s): 米瀬一朗、今留謙一、小林大輔、山本浩平、三浦修、新井文子.
  • Organizer: 第13回EBウイルス研究会.
  • Place of Presentation: 東京都港区
  • Year and Date: 2016-07-09
• [Presentation] EBV陽性T,NKリンパ増殖症におけるEBV特異的CTL活性. (2016)
  • Author(s): 柴山春奈、今留謙一、小野澤枝里香、廿楽明穂、青木奨、三浦修、小山高敏、新井文子.
  • Organizer: 第5回日本血液学会関東甲信越地方会
  • Place of Presentation: 新潟県新潟市
  • Year and Date: 2016-07-02
• [Presentation] 慢性活動性EBウイルス感染症における炎症性サイトカインの産生の解析. (2016)
  • Author(s): 小野澤枝里香、柴山春奈、今留謙一、廿楽明穂、青木奨、小山高敏、三浦修、新井文子.
  • Organizer: 第5回日本血液学会関東甲信越地方会
  • Place of Presentation: 新潟県新潟市
  • Year and Date: 2016-07-02
• [Presentation] 蚊刺過敏症で発症しT細胞リンパ腫へ進展したEBウイルス陽性Tリンパ増殖症. (2016)
  • Author(s): 米瀬一朗、今留謙一、小林大輔、山本浩平、三浦修、新井文子.
  • Organizer: 第5回日本血液学会関東甲信越地方会
  • Place of Presentation: 新潟県新潟市
  • Year and Date: 2016-07-02
• [Presentation] 慢性活動性EBウイルス感染症に合併した末梢神経障害の臨床的特徴. (2016)
  • Author(s): 天野永一朗，大久保卓哉，服部高明，齊藤麻美，東山雄一，児矢野繁，田中章景，新井文子，三浦修，横田隆徳.
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2016-05-19
• [Presentation] EBV陽性T,NKリンパ増殖症に対するBortezomibの有用性の検討. (2016)
  • Author(s): 柴山春奈、今留謙一、藤原成悦、渡邊健、清水則夫、坂下千瑞子、小山高敏、三浦修、新井文子.
  • Organizer: 第25回EBV感染症研究会
  • Place of Presentation: ヤクルトホール （東京）
  • Year and Date: 2016-03-20
• [Presentation] EBウイルス陽性T/NKリンパ増殖性疾患のFDG-PET/CT所見とその有用性の検討. (2016)
  • Author(s): 鳥井原彰、新井文子、中館雅志、山本浩平、今留謙一、三浦修、立石宇貴秀.
  • Organizer: 第25回EBV感染症研究会
  • Place of Presentation: ヤクルトホール （東京）
  • Year and Date: 2016-03-20
• [Presentation] 皮疹部に血球貪食像を認め血球貪食症候群を合併したEBV-positive NK-lymphoproliferative diseaseの１例. (2016)
  • Author(s): 野老翔雲、並木剛、乾恵子、三浦圭子、渡邉健、今留謙一、新井文子、横関博雄.
  • Organizer: 第25回EBV感染症研究会
  • Place of Presentation: ヤクルトホール （東京）
  • Year and Date: 2016-03-20
• [Presentation] Gene expression profiling of primary vitreoretinal lymphoma. (2015)
  • Author(s): Arai A, Hiroshi Takase, Kouhei Yamamoto, Hiroki Akiyama, Manabu Mochizuki, Osamu Miura.
  • Organizer: 57th ASH Annual Meeting and Exposition
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-12-05
  • Int'l Joint Research
• [Presentation] FDG-PET/CT of Epstein-Barr virus-related lymphoproliferative disorders: knowledge for rapid and appropriate diagnosis. (2015)
  • Author(s): Toriihara A, Nakajima R, Arai A, Nakadate M, AbeK, Kubota K, Tateishi U.
  • Organizer: 101nd Scientific Assembly and Annual Meeting of Radiological Society of North America
  • Place of Presentation: Chicago, USA
  • Year and Date: 2015-11-29
  • Int'l Joint Research
• [Presentation] Gene expression profiling of primary vitreoretinal lymphoma. (2015)
  • Author(s): Arai A, Hiroshi Takase, Kouhei Yamamoto, Hiroki Akiyama, Manabu Mochizuki, Miura O.
  • Organizer: 第77回日本血液学会総会
  • Place of Presentation: 石川県立音楽堂他 （金沢）
  • Year and Date: 2015-10-16
• [Presentation] Postgraduate education in Kampo (traditional Japanese) medicine: A current survey of clinical training hospitals (2015)
  • Author(s): Arai M, Arai A, Izumi S
  • Organizer: An International Association of Medical Education (AMEE)
  • Place of Presentation: Glasgow, UK
  • Year and Date: 2015-09-05
  • Int'l Joint Research
• [Presentation] 脳病変より節外性NK/T細胞リンパ腫と確定診断されたEBウイルス陽性ぶどう膜炎の1例 (2015)
  • Author(s): 今井彩乃,高瀬博,松田剛,今留謙一,大西威一郎,鴨居功樹, 望月學,大野京子,新井文子.
  • Organizer: 第49回日本眼炎症学会
  • Place of Presentation: コングレコンベンションセンター （山口）
  • Year and Date: 2015-07-10
• [Presentation] 両眼性汎ぶどう膜炎症状を呈したEBウイルス陽性Tリンパ増殖症の２例. (2015)
  • Author(s): 高橋洋如、高瀬博、寺田裕紀子、鴨居功樹、新井文子、大野京子.
  • Organizer: 第119回日本眼科学会総会
  • Place of Presentation: ロイトン札幌 （札幌）
  • Year and Date: 2015-04-16
• [Book] 「今日の臨床サポート」改訂第3版 血球貪食症候群 (2017)
  • Author(s): 新井文子
  • Total Pages: 10
  • Publisher: エルゼビア
• [Book] 慢性活動性EBウイルス感染症とその類縁疾患の診療ガイドライン2016, (2016)
  • Author(s): 木村宏編集, 新井文子, 今留謙一, 澤田明久ら.
  • Total Pages: 5
  • Publisher: 診断と治療社
• [Book] 血液研修ノート (2016)
  • Author(s): 9.新井文子
  • Total Pages: 3
  • Publisher: 診断と治療社
• [Remarks] 東京医科歯科大学大学院医歯学総合研究科先端血液検査学新井研究室
  • URL: https://labohematology.jimdo.com/