Novel regulatory mechanism of B-cell lymphoma
| Project/Area Number |
15K09491
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Aichi Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
Odkhuu Erdenezaya 愛知医科大学, 医学部, 助教 (40737681)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | MD-1 / RP105 / 脂質受容体 / S1P |
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| Outline of Final Research Achievements |
As a new control structure of B cell lymphoma, B-cell activated control by serum protein MD-1 was suggested. Because MD-1 is a lipid binding molecule and it also associates with RP105 inducing B-cell activation, lipid combination and the connection with the B-cell activation are thought about. Further analysis is necessary how the B cell lymphoma tendency is gained in the MD-1 deleted SLE model mouse by the B-cell activation reinforcement through Lipid and the receptor.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] C4b binding protein negatively regulates TLR1/2 response2017
Author(s)
Naoko Morita, Ikuko Yamai, Koichiro Takahashi,Yutaka Kusumoto, Takuma Shibata, Toshihiko Kobayashi, Mayumi I Nonaka, Isao Ichimonji, Hidekazu Takagi, Kensuke Miyake and Sachiko A Takamura.
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Journal Title
Innate Immunity
Volume: 23
Pages: 11-19
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Inflammatory responses increase secretion of MD-1 protein.2016
Author(s)
Thomas Jennings R, Odkhuu E, Nakashima A, Morita N, Kobayashi T, Yamai I, Tanaka M, Suganami T, Haga S, Ozaki M, Watanabe Y, Nagai Y, Takatsu K, Kikuchi-Ueda T, Ichimonji I, Ogawa Y, Takagi H, Yamazaki T, Miyake K, Akashi-Takamura S
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Journal Title
Int Immunol
Volume: 28
Pages: 503-512
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Inflammatory responses increase secretion of MD-1 protein2017
Author(s)
Sachiko Akashi Takamura, Jennings Thomas Richard, Odkhoo Erdenezaya, Akina Nakashima, Naoko Morita, Toshihiko Kobayashi, Miyako Tanaka, Takayoshi Suganami, Sanae Haga, Yoshinori Nagai, Kensuke Miyake
Organizer
第19回武田科学振興財団生命科学シンポジウム 慢性炎症・機序と制御
Place of Presentation
大阪 武田科学振興財団
Year and Date
2017-01-20
Related Report
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[Presentation] Novel antibodies detect the increased level of soluble MD-1 during inflammation2016
Author(s)
Akashi-Takamura Sachiko, Jennings Richard, Nakashima Akina, Motita Naoko, Kobayashi Toshihiko, Watanabe Yasuharu, Nagai Yoshinori, Takatsu Kiyoshi, Kikuchi-Ueda Takane, Ichimonji Isao, Takagi Hidekazu, Yamazaki Tatsuya, Miyake Kensuke
Organizer
第45回日本免疫学会総会・学術集会
Place of Presentation
沖縄コンベンションセンター
Year and Date
2016-12-05
Related Report
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