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Novel regulatory mechanism of B-cell lymphoma

Research Project

Project/Area Number 15K09491
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hematology
Research InstitutionAichi Medical University

Principal Investigator

Akashi-Takamura Sachiko  愛知医科大学, 医学部, 教授 (00325599)

Co-Investigator(Renkei-kenkyūsha) Odkhuu Erdenezaya  愛知医科大学, 医学部, 助教 (40737681)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
KeywordsMD-1 / RP105 / 脂質受容体 / S1P
Outline of Final Research Achievements

As a new control structure of B cell lymphoma, B-cell activated control by serum protein MD-1 was suggested. Because MD-1 is a lipid binding molecule and it also associates with RP105 inducing B-cell activation, lipid combination and the connection with the B-cell activation are thought about. Further analysis is necessary how the B cell lymphoma tendency is gained in the MD-1 deleted SLE model mouse by the B-cell activation reinforcement through Lipid and the receptor.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (30 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (3 results) Journal Article (9 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 9 results,  Open Access: 5 results,  Acknowledgement Compliant: 2 results) Presentation (14 results) (of which Int'l Joint Research: 1 results) Book (2 results) Remarks (2 results)

  • [Int'l Joint Research] モンゴル大学(モンゴル)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] アイルランド大学(アイルランド)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] モンゴル大学(モンゴル)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Neutralizing Antibodies Induced by Gene-Based Hydrodynamic Injection Have a Therapeutic Effect in Lethal Influenza Infection2018

    • Author(s)
      Yamazaki Tatsuya、Nagashima Maria、Ninomiya Daisuke、Ainai Akira、Fujimoto Akira、Ichimonji Isao、Takagi Hidekazu、Morita Naoko、Murotani Kenta、Hasegawa Hideki、Chiba Joe、Akashi-Takamura Sachiko
    • Journal Title

      Frontiers in Immunology

      Volume: 9 Pages: 47-47

    • DOI

      10.3389/fimmu.2018.00047

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epithelial membrane protein 3 (Emp3) downregulates induction and function of cytotoxic T lymphocytes by macrophages via TNF-α production2018

    • Author(s)
      Kusumoto Yutaka、Okuyama Hiromi、Shibata Takuma、Konno Kazunori、Takemoto Yusuke、Maekawa Daisuke、Kononaga Tomoyuki、Ishii Takashi、Akashi-Takamura Sachiko、Saitoh Shin-ichiroh、Ikebuchi Ryoyo、Moriya Taiki、Ueda Mizuki、Miyake Kensuke、Ono Shiro、Tomura Michio
    • Journal Title

      Cellular Immunology

      Volume: 324 Pages: 33-41

    • DOI

      10.1016/j.cellimm.2017.12.001

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Core fucose is critical for CD14-dependent Toll-like receptor 4 signaling2017

    • Author(s)
      4.Iijima J, Kobayashi S, Kitazume S*, Kizuka Y, Fujinawa R, Korekane H, Shibata T, Saitoh S, Akashi-Takamura S, Miyake K, Miyoshi E, and Taniguch N
    • Journal Title

      Glycobiology

      Volume: 2017 Issue: 11 Pages: 1006-1015

    • DOI

      10.1093/glycob/cwx075

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Funiculosin variants and phosphorylated derivatives promote innate immune responses via the Toll-like receptor 4/myeloid differentiation factor-2 complex2017

    • Author(s)
      Okamoto N, Mizote K, Honda H, Saeki A, Watanabe Y, Yamaguchi-Miyamoto T, Fukui R, Tanimura N, Motoi Y, Akashi-Takamura S, Kato T, Fujishita S, Kimura T, Ohto U, Shimizu T, Hirokawa T, Miyake K, Fukase K, Fujimoto Y, Nagai Y, Takatsu K
    • Journal Title

      Journal of Biological Chemistry

      Volume: 292 Issue: 37 Pages: 15378-15394

    • DOI

      10.1074/jbc.m117.791780

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] C4b-binding protein negatively regulates TLR4/MD-2 response but not TLR3 response2017

    • Author(s)
      Morita Naoko、Yamazaki Tatsuya、Murakami Yusuke、Fukui Ryutaro、Yamai Ikuko、Ichimonji Isao、Nakashima Akina、Nagaoka Fumiaki、Takagi Hidekazu、Miyake Kensuke、Akashi-Takamura Sachiko
    • Journal Title

      FEBS Letters

      Volume: 591 Issue: 12 Pages: 1732-1741

    • DOI

      10.1002/1873-3468.12693

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C4b binding protein negatively regulates TLR1/2 response2017

    • Author(s)
      Naoko Morita, Ikuko Yamai, Koichiro Takahashi,Yutaka Kusumoto, Takuma Shibata, Toshihiko Kobayashi, Mayumi I Nonaka, Isao Ichimonji, Hidekazu Takagi, Kensuke Miyake and Sachiko A Takamura.
    • Journal Title

      Innate Immunity

      Volume: 23 Issue: 1 Pages: 11-19

    • DOI

      10.1177/1753425916672312

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Inflammatory responses increase secretion of MD-1 protein2016

    • Author(s)
      Thomas Jennings R, Odkhuu E, Nakashima A, Morita N, Kobayashi T, Yamai I, Tanaka M, Suganami T, Haga S, Ozaki M, Watanabe Y, Nagai Y, Takatsu K, Kikuchi-Ueda T, Ichimonji I, Ogawa Y, Takagi H, Yamazaki T, Miyake K, Akashi-Takamura S
    • Journal Title

      International Immunology

      Volume: 28 Issue: 10 Pages: 503-512

    • DOI

      10.1093/intimm/dxw031

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Delayed liver regeneration in C3H/HeJ mice: possible involvement of haemodynamic and structural changes in the hepatic microcirculation2016

    • Author(s)
      Marlini M, Mabuchi A, Mallard BL, Hairulhisyam N, Akashi-Takamura S, Harper JL, Wheatley AM
    • Journal Title

      Experimental Physiology

      Volume: 101 Issue: 12 Pages: 1492-1505

    • DOI

      10.1113/ep085727

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Eritoran inhibits S100A8-mediated TLR4/MD-2 activation and tumor growth by changing the immune microenvironment.2016

    • Author(s)
      Deguchi A, Tomita T, Ohto U, Takemura K, Kitao A, Akashi-Takamura, S, Miyake K, and Maru Y.
    • Journal Title

      Oncogene

      Volume: 35 Issue: 11 Pages: 1445-1456

    • DOI

      10.1038/onc.2015.211

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Inflammatory responses increase secretion of MD-1 protein2017

    • Author(s)
      Sachiko Akashi Takamura, Jennings Thomas Richard, Odkhoo Erdenezaya, Akina Nakashima, Naoko Morita, Toshihiko Kobayashi, Miyako Tanaka, Takayoshi Suganami, Sanae Haga, Yoshinori Nagai, Kensuke Miyake
    • Organizer
      第19回武田科学振興財団生命科学シンポジウム 慢性炎症・機序と制御
    • Place of Presentation
      大阪 武田科学振興財団
    • Year and Date
      2017-01-20
    • Related Report
      2016 Research-status Report
  • [Presentation] 補体制御因子 C4BP は TLR4/MD-2 応答も制御する2017

    • Author(s)
      高村祥子、森田奈央子、山崎達也
    • Organizer
      日本エンドトキシン・自然免疫研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] インフルエンザウイルス感染に対する中和抗体遺伝子を用いた治療法の検討2017

    • Author(s)
      山崎達也、千葉 丈 、高村(赤司)祥子
    • Organizer
      日本エンドトキシン・自然免疫研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] C4b binding protein negatively regulates cell-surface TLRs response2017

    • Author(s)
      Sachiko Akashi-Takamura, Naoko Morita, Tatsuya Yamazaki, Isao Ichimonji, Yusuke Murakami, Ryutaro Fukui, Takuma Shibata, Toshihiko Kobayashi, Yutaka Kusumoto, Kensuke Miyake
    • Organizer
      日本免疫学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Neutralizing antibodies induced by gene-base hydrodynamic injection have a therapeutic effect in nasal influenza virus infection2017

    • Author(s)
      Tatsuya Yamazaki, Akira Ainai, Isao Ichimonji, Naoko Morita, Sachiko Akashi-Takamura
    • Organizer
      日本免疫学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Novel antibodies detect the increased level of soluble MD-1 during inflammation2016

    • Author(s)
      Akashi-Takamura Sachiko, Jennings Richard, Nakashima Akina, Motita Naoko, Kobayashi Toshihiko, Watanabe Yasuharu, Nagai Yoshinori, Takatsu Kiyoshi, Kikuchi-Ueda Takane, Ichimonji Isao, Takagi Hidekazu, Yamazaki Tatsuya, Miyake Kensuke
    • Organizer
      第45回日本免疫学会総会・学術集会
    • Place of Presentation
      沖縄コンベンションセンター
    • Year and Date
      2016-12-05
    • Related Report
      2016 Research-status Report
  • [Presentation] Antibody-based immunotherapy with plasmid vector for influenza virus infection2016

    • Author(s)
      Yamazaki Tatsuya, Ainai Akira, Akashi-Takamura Sachiko
    • Organizer
      第45回日本免疫学会総会・学術集会
    • Place of Presentation
      沖縄コンベンションセンター
    • Year and Date
      2016-12-05
    • Related Report
      2016 Research-status Report
  • [Presentation] Regulatory roles against sphingosine-1-phosphate activity via MD-12016

    • Author(s)
      Tanimura Natsuko, Takamura Sachiko, Miyake Kensuke
    • Organizer
      第45回日本免疫学会総会・学術集会
    • Place of Presentation
      沖縄コンベンションセンター
    • Year and Date
      2016-12-05
    • Related Report
      2016 Research-status Report
  • [Presentation] Agonistic effects of synthetic derivatives of funiculosin on mouse/human TLR4/MD-22016

    • Author(s)
      Okamoto Naoki, Honda Hiroe, Akashi-Takamura Sachiko,Nagai Yoshinori, Takatsu Kiyoshi
    • Organizer
      第45回日本免疫学会総会・学術集会
    • Place of Presentation
      沖縄コンベンションセンター
    • Year and Date
      2016-12-05
    • Related Report
      2016 Research-status Report
  • [Presentation] Novel antibodies detect the increased level of soluble MD-1 during inflammation2016

    • Author(s)
      Sachiko Akashi-Takamura
    • Organizer
      第22回日本エンドトキシン・自然免疫研究会
    • Place of Presentation
      鹿児島大学
    • Year and Date
      2016-12-02
    • Related Report
      2016 Research-status Report
  • [Presentation] MD-1 is a valuable biomarker for inflammatory responses2016

    • Author(s)
      Richard Thomas Jennings, Erdenezaya Odkhuu, Kensuke Miyake, and Sachiko Akashi-Takamura、et al.
    • Organizer
      Keystone Symposia Q7&Q8 (Immunometabolism in Immune Function and Inflammatory Disease)
    • Place of Presentation
      Canada Banff
    • Year and Date
      2016-02-23
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 補体系制御因子C4BPはTLR2応答も制御する2015

    • Author(s)
      森田奈央子、高村(赤司)祥子
    • Organizer
      第21回日本エンドトキシン・自然免疫研究会
    • Place of Presentation
      東京
    • Year and Date
      2015-12-05
    • Related Report
      2015 Research-status Report
  • [Presentation] C4b-binding protein influences TLR2 response2015

    • Author(s)
      Naoko Morita, Eredenezaya Odkhoo, Isao Ichimonji, Kensuke Miyake, Sachiko Akashi-Takamura
    • Organizer
      日本免疫学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2015-11-18
    • Related Report
      2015 Research-status Report
  • [Presentation] MD-1 negatively regulates B cell-related inflammation2015

    • Author(s)
      Natsuko Tanimura, Sachiko Akashi-Takamura, Natsuko Yamakawa and Kensuke Miyake
    • Organizer
      日本免疫学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2015-11-18
    • Related Report
      2015 Research-status Report
  • [Book] エンドトキシン・自然免疫研究会20自然免疫における化学生物学の貢献2017

    • Author(s)
      一文字 功、高村(赤司)祥子
    • Total Pages
      82
    • Publisher
      医学図書出版株式会社
    • ISBN
      9784865171938
    • Related Report
      2017 Annual Research Report
  • [Book] エンドトキシン・自然免疫研究19 新たなる基礎と臨床の架け橋2016

    • Author(s)
      森田奈央子、高村(赤司)祥子
    • Total Pages
      5
    • Publisher
      医学図書出版株式会社
    • Related Report
      2016 Research-status Report
  • [Remarks] 愛知医科大学 医学部 感染・免疫学講座2

    • URL

      http://www.aichi-med-u.ac.jp/M-I2/index.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 愛知医科大学感染免疫学講座・免疫寄生虫学教室

    • URL

      http://www.aichi-med-u.ac.jp/M-I2/index.html

    • Related Report
      2016 Research-status Report 2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-12-27  

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