Analysis of the function of Ptprz1 during the development of HSC in mouse embryo
| Project/Area Number |
15K09495
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2015-10-21 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 造血幹細胞出現機構 / 受容体型ホスファターゼ / 造血幹細胞発生 / 造血幹細胞前駆体 / 受容体チロシンフォスファターゼ / 造血幹細胞 / 受容体型チロシンホスファターゼ |
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| Outline of Final Research Achievements |
In this study, we investigated the role of Ptprz1, which is expressed at the appearance of cluster cells that form the basis of hematopoietic stem cells. Based on the fact that Ptprz 1 is expressed in vascular endothelial cells in the clustering cell appearance region in the mouse embryo and from the experiment that inhibits the activity of Ptprz 1, cluster cells are decreased, Ptprz 1 is transformed from intravascular cells to cluster cells It was suggested that it is involved in migration / differentiation. It is expected that these knowledge will help the development of hematopoietic stem cell induction and acquisition technology in the cell culture system.
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Report
(4 results)
Research Products
(2 results)
