Development of transgenic T lymphocytes to break down the immunosuppressive tumor microenvironment and its functional analysis

• Project/Area Number: 15K09497
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: Nagoya University
• Principal Investigator: Terakura Seitaro 名古屋大学, 医学部附属病院, 助教 (40625141)
• Research Collaborator: OKUNO Shingo ; JULAMANEE Jakrawadee ; MIYAO Kotaro ; SAKEMURA Reona
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: キメラ抗原レセプター / 遺伝子導入T細胞療法 / CD8陽性細胞 / Tリンパ球 / 腫瘍微小環境 / CD8陽性

Outline of Final Research Achievements

Based on the amino acid sequence information of the antibody against the molecule PD-L1 thought to be expressed on tumor cells in order that tumor cells escape from immune cells, a single-chain antibody binding to PD-L1 was prepared. We further created a novel molecule with CD28 or 4-1BB or both as a part of domain. When this antibody was stained by fluorescent-labeled PD-L1 molecule, it was found that it stained well, indicating that it binds well to the antigen. This gene was transfected into T lymphocytes and its function was examined in vitro and in vivo in mice. On the other hand, we tried to knock out CTLA-4 molecule, which is expressed after activation of T cells and supposedly acts suppressively on self.

Research Products

• [Journal Article] MonoMAC syndrome patient developing myelodysplastic syndrome following persistent EBV infection (2018)
  • Author(s): Yamamoto H, Hattori H, Takagi E, Morishita T, Ishikawa Y, Terakura S, Nishida T, Ito Y, Murata M, Kiyoi H.
  • Journal Title: Rinsho Ketsueki Volume: 59 Issue: 3 Pages: 315-322
  • DOI: 10.11406/rinketsu.59.315
  • NAID: 130006627422
  • ISSN: 0485-1439, 1882-0824
  • Peer Reviewed
• [Journal Article] Exploratory research for optimal GvHD prophylaxis after single unit CBT in adults: short-term methotrexate reduced the incidence of severe GvHD more than mycophenolate mofetil. (2017)
  • Author(s): Terakura S, Wake A, Inamoto Y, Murata M, Sakai R, Yamaguchi T, Takahashi S, Uchida N, Onishi Y, Ohashi K, Ozawa Y, Kanamori H, Yamaguchi H, Fukuda T, Ichinohe T, Takanashi M, Atsuta Y, Teshima T.
  • Journal Title: Bone Marrow Transplant Volume: 52 Issue: 3 Pages: 423-430
  • DOI: 10.1038/bmt.2016.255
  • Peer Reviewed
• [Journal Article] Impact of T-cell chimerism on relapse after cord blood transplantation for hematological malignancies: Nagoya Blood and Marrow Transplantation Group study (2017)
  • Author(s): Yokohata E, Kuwatsuka Y, Ohashi H, Terakura S, Kawashima N, Seto A, Kurahashi S, Ozawa Y, Goto T, Imahashi N, Nishida T, Miyao K, Sakemura R, Kato T, Sawa M, Kohno A, Sao H, Iida H, Kiyoi H, Naoe T, Miyamura K, Murata M
  • Journal Title: Bone Marrow Transplant. Volume: in press Issue: 4 Pages: 612-614
  • DOI: 10.1038/bmt.2016.323
  • Peer Reviewed
• [Journal Article] Phase II study of intrabone single unit cord blood transplantation for hematological malignancies (2017)
  • Author(s): Murata Makoto、Maeda Yoshinobu、Masuko Masayoshi、et.al
  • Journal Title: Cancer Science Volume: 108 Issue: 8 Pages: 1634-1639
  • DOI: 10.1111/cas.13291
  • Peer Reviewed / Open Access
• [Journal Article] Increase of bone marrow macrophages and CD8+ T lymphocytes predict graft failure after allogeneic bone marrow or cord blood transplantation. (2017)
  • Author(s): Kawashima N, Terakura S, Nishiwaki S, Koyama D, Ozawa Y, Ito M, Miyamura K
  • Journal Title: Bone Marrow Transplantation Volume: 52 Issue: 8 Pages: 1164-1170
  • DOI: 10.1038/bmt.2017.58
  • Peer Reviewed
• [Journal Article] GvHD prophylaxis after single-unit reduced intensity conditioning cord blood transplantation in adults with acute leukemia (2017)
  • Author(s): Terakura S, Kuwatsuka Y, Yamasaki S, Wake A, Kanda J, Inamoto Y, Mizuta S, Yamaguchi T, Uchida N, Kouzai Y, Aotsuka N, Ogawa H, Kanamori H, Nishiwaki K, Miyakoshi S, Onizuka M, Amano I, Fukuda T, Ichinohe T, Atsuta Y, Murata M, Teshima T
  • Journal Title: Bone Marrow Transplant Volume: 52 Issue: 9 Pages: 1261-1267
  • DOI: 10.1038/bmt.2017.116
  • NAID: 120006367975
  • Peer Reviewed
• [Journal Article] High incidence of extensive chronic graft-versus-host disease in patients with the REG3A rs7588571 non-GG genotype (2017)
  • Author(s): Koyama Daisuke、Murata Makoto、Hanajiri Ryo、Okuno Shingo、Kamoshita Sonoko、Julamanee Jakrawadee、Takagi Erina、Hirano Daiki、Miyao Kotaro、Sakemura Reona、Goto Tatsunori、Hayakawa Fumihiko、Seto Aika、Ozawa Yukiyasu、Miyamura Koichi、Terakura Seitaro、Nishida Tetsuya、Kiyoi Hitoshi
  • Journal Title: PLoS One Volume: 12 Issue: 9 Pages: e0185213-e0185213
  • DOI: 10.1371/journal.pone.0185213
  • Peer Reviewed / Open Access
• [Journal Article] Safety and persistence of WT1-specific T-cell receptor gene-transduced lymphocytes in patients with AML and MDS. (2017)
  • Author(s): Tawara I, Kageyama S, Miyahara Y, Fujiwara H, Nishida T, Akatsuka Y, Ikeda H, Tanimoto K, Terakura S, Murata M, Inaguma Y, Masuya M, Inoue N, Kidokoro T, Okamoto S, Tomura D, Chono H, Nukaya I, Mineno J, Naoe T, Emi N, Yasukawa M, Katayama N, Shiku H.
  • Journal Title: Blood Volume: 130 Issue: 18 Pages: 1985-1994
  • DOI: 10.1182/blood-2017-06-791202
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The activated conformation of integrin β7 as a target for multiple myeloma-specific chimeric antigen receptor T cell therapy. (2017)
  • Author(s): Hosen N, Matsunaga Y, Hasegawa K, Matsuno H, Nakamura Y, Makita M, Watanabe K, Yoshida M, Satoh K, Morimoto S, Fujiki F, Nakajima H, Nakata J, Nishida S, Tsuboi A, Oka Y, Manabe M, Ichihara H, Aoyama Y, Mugitani A, Nakao T, Hino M, Uchibori R, Ozawa K, Baba Y, et al.
  • Journal Title: Nat. Med. Volume: 23 Issue: 12 Pages: 1436-1443
  • DOI: 10.1038/nm.4431
  • Peer Reviewed
• [Journal Article] Efficacy and safety of autologous peripheral blood stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia: A study protocol for a multicenter exploratory prospective study (Auto-Ph17 study). (2017)
  • Author(s): Nishiwaki S, Sugiura I, Miyata Y, Saito S, Sawa M, Nishida T, Miyamura K, Kuwatsuka Y, Kohno A, Yuge M, Kasai M, Iida H, Kurahashi S, Osaki M, Goto T, Terakura S, Murata M, Nishikawa H, Kiyoi H
  • Journal Title: Medicine Volume: 96 Issue: 52 Pages: e9568-e9568
  • DOI: 10.1097/md.0000000000009568
  • Peer Reviewed / Open Access
• [Journal Article] Impact of graft-versus-host disease on outcomes after unrelated cord blood transplantation. (2017)
  • Author(s): Kanda J, Morishima Y, Terakura S, Wake A, Uchida N, Takahashi S, Ono Y, Onishi Y, Kanamori H, Aotsuka N, Ozawa Y, Ogawa H, Sakura T, Ohashi K, Ichinohe T, Kato K, Atsuta Y, Teshima T, Murata M.
  • Journal Title: Leukemia Volume: 31(3) Issue: 3 Pages: 663-668
  • DOI: 10.1038/leu.2016.288
  • Peer Reviewed / Open Access
• [Journal Article] Malignant lymphoma with cardiac involvement (2017)
  • Author(s): Terakura S, Onji M, Iriyama C, Goto T, Ushijima Y, Shimada K, Ishikawa Y, Nishida T, Hayakawa F, Murata M, Kiyoi H
  • Journal Title: Rinsho Ketsueki Volume: 58 Issue: 3 Pages: 239-242
  • DOI: 10.11406/rinketsu.58.239
  • NAID: 130005549372
  • ISSN: 0485-1439, 1882-0824
  • Peer Reviewed
• [Journal Article] Programmed Death-Ligand 1 on Antigen-presenting Cells Facilitates the Induction of Antigen-specific Cytotoxic T Lymphocytes: Application to Adoptive T-Cell Immunotherapy (2016)
  • Author(s): Goto T, Nishida T, Takagi E, Miyao K, Koyama D, Sakemura R, Hanajiri R, Watanabe K, Imahashi N, Terakura S, Murata M, Kiyoi H
  • Journal Title: J Immunother. Volume: 39 Issue: 8 Pages: 306-315
  • DOI: 10.1097/cji.0000000000000136
  • Peer Reviewed
• [Journal Article] A Tet-On Inducible System for Controlling CD19-Chimeric Antigen Receptor Expression upon Drug Administration (2016)
  • Author(s): Sakemura R, Terakura S, Watanabe K, Julamanee J, Takagi E, Miyao K, Koyama D, Goto T, Hanajiri R, Nishida T, Murata M, Kiyoi H
  • Journal Title: Cancer Immunol Res. Volume: 4 Issue: 8 Pages: 658-668
  • DOI: 10.1158/2326-6066.cir-16-0043
  • Peer Reviewed
• [Journal Article] Comparison of Outcomes of 8/8 and 7/8 Allele-Matched Unrelated Bone Marrow Transplantation and Single-Unit Cord Blood Transplantation in Adults with Acute Leukemia. (2016)
  • Author(s): Terakura S, Atsuta Y, Tsukada N, Kobayashi T, Tanaka M, Kanda J, Najima Y, Fukuda T, Uchida N, Takahashi S, Nagamura-Inoue T, Morishima Y, Miyamura
  • Journal Title: Biol Blood Marrow Transplant. Volume: 22 Issue: 2 Pages: 330-338
  • DOI: 10.1016/j.bbmt.2015.10.006
  • Peer Reviewed
• [Journal Article] Integration of humoral and cellular HLA-specific immune responses in cord blood allograft rejection. (2015)
  • Author(s): Hanajiri R, Murata M, Sugimoto K, Murase M, Sakemura R, Goto T, Watanabe K, Imahashi N, Terakura S, Ohashi H, Akatsuka Y, Kurahashi S, Miyamura K, Kiyoi H, Nishida T, Naoe T
  • Journal Title: Bone Marrow Transplant. Volume: 50 Issue: 9 Pages: 1187-1194
  • DOI: 10.1038/bmt.2015.119
  • Peer Reviewed
• [Journal Article] Cutaneous macrophage infiltration in acute GvHD. (2015)
  • Author(s): Terakura S, Martin PJ, Shulman HM, Storer BE.
  • Journal Title: Bone Marrow Transplant. Volume: 50 Issue: 8 Pages: 1135-1137
  • DOI: 10.1038/bmt.2015.114
  • Peer Reviewed
• [Journal Article] Chimerism status after unrelated donor bone marrow transplantation with fludarabine-melphalan conditioning is affected by the melphalan dose and is predictive of relapse. (2015)
  • Author(s): Imahashi N, Ohashi H, Terakura S, Miyao K, Sakemura R, Kato T, Sawa M, Yokohata E, Kurahashi S, Ozawa Y, Nishida T, Kiyoi H, Watamoto K, Kohno A, Kasai M, Kato C, Iida H, Naoe T, Miyamura K, Murata M
  • Journal Title: Ann Hematol. Volume: 94 Issue: 7 Pages: 1139-1148
  • DOI: 10.1007/s00277-015-2312-4
  • Peer Reviewed
• [Presentation] 臍帯血移植における免疫抑制療法 (2018)
  • Author(s): 寺倉精太郎
  • Organizer: 第40回日本造血細胞移植学会総会
  • Invited
• [Presentation] Genetically-Modified CD3zeta Improves Proliferation and Persistence of Antigen-specific CTLs. (2018)
  • Author(s): Miyao K, Terakura S, Okuno S, Jakrawadee J, Watanabe K, Hamana H, Kishi H, Sakemura R, Koyama D, Goto T, Nishida T, Murata M, Kiyoi H.
  • Organizer: 第40回日本造血細胞移植学会総会
• [Presentation] REG3A遺伝子の一塩基多型rs7588571が非GG型の患者では広範型慢性GVHDの発症頻度が高い. (2018)
  • Author(s): 村田誠、小山大輔、葉名尻良、奥野真吾、鴨下園子、Julamanee Jakrawadee、高木えり奈、平野大希、宮尾康太郎、酒村玲央奈、後藤辰徳、早川文彦、瀬戸愛花、小澤幸泰、宮村耕一、寺倉精太郎、西田徹也、清井仁.
  • Organizer: 第40回日本造血細胞移植学会総会
• [Presentation] ステロイド抵抗性急性GVHDに対するヒト骨髄由来間葉系幹細胞治療：単一施設における後方視的検討. (2017)
  • Author(s): 村田誠、松下正、後藤辰徳、入山智沙子、寺倉精太郎、西田徹也、清井仁
  • Organizer: 第16回日本再生医療学会総会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2017-03-07
• [Presentation] ヒトGVHD組織におけるアロ反応性T細胞の解析. (2017)
  • Author(s): 小山大輔、村田 誠、奥野真吾、鴨下園子、Jakrawadee Julamanee、高木えり奈、宮尾康太郎、後藤辰徳、酒村玲央奈、葉名尻 良、寺倉精太郎、西田徹也、清井仁.
  • Organizer: 第39回日本造血細胞移植学会総会
  • Place of Presentation: くにびきメッセ・島根県民会館（島根県松江市）
  • Year and Date: 2017-03-02
• [Presentation] 当院におけるステロイド治療抵抗性急性GVHDに対するヒト間葉系幹細胞治療の後方視的検討 (2017)
  • Author(s): 後藤辰徳、入山智沙子、寺倉精太郎、西田徹也、村田 誠、清井仁
  • Organizer: 第39回日本造血細胞移植学会総会
  • Place of Presentation: くにびきメッセ・島根県民会館（島根県松江市）
  • Year and Date: 2017-03-02
• [Presentation] Improvement of antigen-specific CTL persistence by transduction of novel artificial adapter molecule. (2017)
  • Author(s): Miyao K, Watanabe K, Terakura S, Hamana H, Kishi H, Nishida T, Murata M, Kiyoi H.
  • Organizer: 日本血液学会国際シンポジウム
• [Presentation] Intrabone single unit cord blood transplantation for hematological malignancies. (2017)
  • Author(s): Murata M, Maeda Y, Masuko M, Fukuhara N, Nishida T, Terakura S, Ishikawa Y, Tanimoto M, Shibasaki Y, Suzuki R, Kodera Y, Kiyoi H, Naoe T
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] 新規人工アダプター分子の遺伝子導入は抗原特異的CTLのpersistenceを向上させる. (2017)
  • Author(s): 宮尾康太郎、寺倉精太郎、奥野真吾、渡邊慶介、浜名洋、岸裕幸、酒村玲央奈、Jakrawadee Julamanee、後藤辰徳、西田徹也、村田誠、清井仁.
  • Organizer: 第9回血液疾患免疫療法学会学術集会
• [Presentation] ヒト急性GVHDにおける組織浸潤アロ反応性T細胞レパトアの定量的評価. (2017)
  • Author(s): 小山大輔、村田誠、葉名尻良、奥野真吾、鴨下園子、高木えり奈、Jakrawadee Julamanee、宮尾康太郎、後藤辰徳、酒村玲央奈、寺倉精太郎、西田徹也、清井仁.
  • Organizer: 第9回血液疾患免疫療法学会学術集会
• [Presentation] 急性白血病に対する減量前治療を用いた臍帯血移植におけるGVHD予防法の比較研究. (2017)
  • Author(s): 寺倉精太郎、鍬塚八千代、山崎聡、和氣敦、諫田淳也、稲本賢弘、水田秀一、山口拓洋、内田直之、香西康司、青墳信之、小川啓恭、金森平和、西脇嘉一、宮腰重三郎、鬼塚真仁、天野逸人、福田隆浩、一戸辰夫、熱田由子、村田誠、豊嶋崇徳.
  • Organizer: 第79回日本血液学会学術集会
• [Presentation] The synergistic T-cell signal by CD79A/CD40 costimulatory endodomain enhances CD19 chimeric antigen receptor T-cell proliferation and survival. (2017)
  • Author(s): Julamanee J, Terakura S, Sakemura R, Miyao K, Okuno S, Kamoshita S, Takagi E, Koyama D, Goto T, Hanajiri R, Nishida T, Murata M, Kiyoi H.
  • Organizer: The 59th annual meeting of the American Society of Hematology
  • Int'l Joint Research
• [Presentation] Quantitative assessment of TCR repertoire and allo-reactivity of human acute GVHD tissue-infiltrating T cells. (2017)
  • Author(s): Koyama D, Murata M, Hanajiri R, Okuno S, Kamoshita S, Takagi E, Julamanee J, Miyao K, Sakemura R, Goto T, Terakura S, Nishida T, Kiyoi H.
  • Organizer: The 59th annual meeting of the American Society of Hematology
  • Int'l Joint Research
• [Presentation] Improvement of antigen-specific CTL persistence by transduction of novel artificial adopter molecule (2016)
  • Author(s): 宮尾康太郎、寺倉精太郎、渡邉慶介、酒村玲央奈、Jakrawadee Julamanee、奥野真吾、鴨下園子、高木えり奈、小山大輔、後藤辰徳、葉名尻良、西田徹也、村田誠、清井仁
  • Organizer: 58th ASH Annual Meeting and Exposition
  • Place of Presentation: San Diego （USA）
  • Year and Date: 2016-12-03
  • Int'l Joint Research
• [Presentation] Intrabone transplantation of a single cord blood unit using non-irradiated reduced-intensity conditioning. (2016)
  • Author(s): Murata M, Maeda Y, Masuko M, Onishi Y, Endo T, Terakura S, Ishikawa Y, Iriyama C, Ushijima Y, Goto T, Fujii N, Tanimoto M, Kobayashi H, Shibasaki Y, Fukuhara N, Inamoto Y, Suzuki R, Matsushita T, Kodera Y, Kiyoi H, Naoe T, Nishida T.
  • Organizer: 58th ASH Annual Meeting and Exposition
  • Place of Presentation: San Diego （USA）
  • Year and Date: 2016-12-03
  • Int'l Joint Research
• [Presentation] Phase 1 clinical trial of adoptive immunotherapy for acute myelogenous leukemia and myelodysplastic syndrome, using gene-modified autologous lymphocytes expressing WT1-specific T-cell receptor. (2016)
  • Author(s): Tanimoto K, Fujiwara H, Tawara I, Masuya M, Kageyama S, Nishida T, Murata M, Terakura S, Akatsuka Y, Ikeda H, Miyahara Y, Nukaya I, Takesako K, Emi N, Katayama N, Shiku H, Yasukawa M.
  • Organizer: 58th ASH Annual Meeting and Exposition
  • Place of Presentation: San Diego （USA）
  • Year and Date: 2016-12-03
  • Int'l Joint Research
• [Presentation] 心臓浸潤を認めた悪性リンパ腫3例の経験 (2016)
  • Author(s): 陰地真晃、入山智沙子、寺倉精太郎、島田和之、石川裕一、西田徹也、早川文彦、村田誠、清井仁
  • Organizer: 第230回日本内科学会東海地方会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2016-10-16
• [Presentation] Rare deletion mutation in PML-RARA and its biological significance in APL (2016)
  • Author(s): 服部 光、 石川裕一、 宮尾康太郎、平野大希、寺倉精太郎、西田徹也、村田 誠、清井 仁
  • Organizer: 第78回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-10-13
• [Presentation] Gene modification by adapter molecule improves the expansion of antigen-specific CTL (2016)
  • Author(s): 宮尾康太郎、寺倉精太郎、渡邊慶介、高木えり奈、Jakrawadee Julamanee, 小山大輔、酒村玲央奈、後藤辰徳、葉名尻良、西田徹也、村田誠、清井仁
  • Organizer: 第78回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-10-13
• [Presentation] REG3A polymorphism is associated with the incidence of extensive chronic GVHD after allogeneic BMT (2016)
  • Author(s): 小山大輔、村田誠 Jakrawadee Julamanee、高木えり奈、宮尾康太郎、酒村玲央奈、後藤辰徳、葉名尻良、瀬戸愛花、小澤幸泰、宮村耕一、寺倉精太郎、西田徹也、清井仁
  • Organizer: 第78回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-10-13
• [Presentation] Adoptive transfer of WT1-specific TCR-gene-transduced T lymphocytes in patients with hematological malignancies. (2016)
  • Author(s): 俵功、藤原弘、村田誠、赤塚美樹、西田徹也、寺倉精太郎、恵美宣彦、桝屋正浩、池田裕明、片山直之、安川正貴、影山慎一、珠玖 洋.
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-10-06
• [Presentation] ヒトGVHD組織におけるアロ反応性T細胞の解析 (2016)
  • Author(s): 小山大輔、村田 誠、奥野真吾、鴨下園子、Jakrawadee Julamanee、高木えり奈、宮尾康太郎、後藤辰徳、酒村玲央奈、葉名尻 良、寺倉精太郎、西田徹也、清井 仁.
  • Organizer: 第8回血液疾患免疫療法学会学術集会
  • Place of Presentation: 北海道大学医学部学友会館「フラテ」(北海道札幌市）
  • Year and Date: 2016-09-03
• [Presentation] 人工アダプター分子の遺伝子導入による抗原特異的CTL療法の改良 (2016)
  • Author(s): 宮尾康太郎、寺倉精太郎、渡邊慶介、酒村玲央奈、奥野真吾、鴨下園子、高木えり奈、Jakrawadee Julamanee、小山大輔、後藤辰徳、葉名尻 良、西田徹也、村田 誠、清井 仁.
  • Organizer: 第8回血液疾患免疫療法学会学術集会
  • Place of Presentation: 北海道大学医学部学友会館「フラテ」(北海道札幌市）
  • Year and Date: 2016-09-03
• [Presentation] A new strategy to control CD19 CAR; regulation under tetracycline-inducible system allows on-demand CD19 CAR expression and disappearance. (2016)
  • Author(s): 酒村玲央奈、寺倉精太郎、Jakrawadee Julamanee、宮尾康太郎、西田徹也、村田 誠、清井 仁.
  • Organizer: 第7回日本血液学会国際シンポジウム
  • Place of Presentation: 淡路夢舞台国際会議場（兵庫県淡路市）
  • Year and Date: 2016-05-13
• [Presentation] ATO不耐容かつATRA耐性変異を獲得し再燃した二次性前骨髄球性白血病の一例 (2016)
  • Author(s): 宮尾康太郎、平野大希、服部光、西山誉大、石川裕一、寺倉精太郎、西田徹也、村田誠、清井仁
  • Organizer: 第５回日本血液学会東海地方会
  • Place of Presentation: ウインク愛知（愛知県名古屋市）
  • Year and Date: 2016-04-23
• [Presentation] 同種造血幹細胞移植後における ドナーT細胞キメリズムと予後との関連に関する検討 (2016)
  • Author(s): 後藤辰徳、寺倉精太郎、 大橋春彦、小山大輔、渡邊慶介、瀬戸愛花、西脇聡史、小澤幸泰、宮尾康太郎、酒村玲央奈、加藤智則、澤正史、 西田徹也、尾関和貴、河野彰夫、飯田浩充、直江知樹、清井仁、宮村耕一、村田誠
  • Organizer: 第38回日本造血細胞移植学会総会
  • Place of Presentation: 愛知県名古屋市 名古屋国際会議場
  • Year and Date: 2016-03-03
• [Presentation] A new strategy to control CD19 CAR expression; regulation under tetracycline-inducible system allows on-demand CD19 CAR expression and disappearance (2016)
  • Author(s): 酒村玲央奈、寺倉精太郎、渡邊慶介、Jakrawadee Julamanee 、 高木えり奈、宮尾康太郎、小山大輔、後藤辰徳、葉名尻良、西田徹也、村田誠、清井仁
  • Organizer: 42nd Annual Meeting of the European Society for Blood and Marrow Transplantation
  • Place of Presentation: バレンシア（スペイン）
  • Int'l Joint Research
• [Presentation] A novel strategy of switching on/off CD19CAR expression under Tetracycline based system (2015)
  • Author(s): 酒村玲央奈、寺倉精太郎、渡邊慶介、宮尾康太郎、小山大輔、後藤辰徳、葉名尻良、西田徹也、村田誠、清井仁
  • Organizer: 57th ASH Annual Meeting and Exposition
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-12-05
  • Int'l Joint Research
• [Presentation] PD-L1 on Antigen-Presenting Cells Facilitate the Induction of Antigen-Specific Cytotoxic T Lymphocytes (2015)
  • Author(s): 後藤辰徳、西田徹也、宮尾康太郎、小山大輔、酒村玲央奈、葉名尻良、渡邊慶介、今橋伸彦、寺倉精太郎、村田誠、清井仁
  • Organizer: 57th ASH Annual Meeting and Exposition
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-12-05
  • Int'l Joint Research
• [Presentation] Adoptive transfer of WT1-specific TCR gene-transduced lymphocytes in patients with myelodysplastic syndrome and acute myeloid leukemia. (2015)
  • Author(s): Tawara I, Masuya M, Kageyama S, Nishida T, Terakura S, Murata M, Fujiwara H, Akatsuka Y, Ikeda H, Miyahara Y, Tomura D, Nukaya I, Takesako K, Emi N, Yasukawa M, Katayama N, Shiku H.
  • Organizer: 57th ASH Annual Meeting and Exposition
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-12-05
  • Int'l Joint Research
• [Presentation] Tracking donor-reactive T cell clones by deep sequencing in cord blood allograft rejection (2015)
  • Author(s): 葉名尻良、村田誠、宮尾康太郎、小山大輔、酒村玲央奈、後藤辰徳、渡邊慶介、寺倉精太郎、西田徹也、清井仁
  • Organizer: 第77回日本血液学会学術集会
  • Place of Presentation: 石川県金沢市 石川県立音楽堂、ANAクラウンプラザホテル金沢、 ホテル日航金沢、ホテル金沢、金沢市アートホール、 もてなしドーム
  • Year and Date: 2015-10-16
• [Presentation] Roles of PD-L1 on antigen-presenting cells for the generation of antigen-specific T cells (2015)
  • Author(s): 後藤辰徳、西田徹也、高木えり奈、宮尾康太郎、小山大輔、酒村玲央奈、葉名尻良、渡邊慶介、今橋伸彦、寺倉 精太郎、村田誠、清井仁
  • Organizer: 第77回日本血液学会学術集会
  • Place of Presentation: 石川県金沢市 石川県立音楽堂、ANAクラウンプラザホテル金沢、 ホテル日航金沢、ホテル金沢、金沢市アートホール、 もてなしドーム
  • Year and Date: 2015-10-16
• [Presentation] Inducible CD19 CAR expression under tetracycline-based regulation system (2015)
  • Author(s): 酒村玲央奈、寺倉精太郎、渡邊慶介、宮尾康太郎、小山大輔、後藤辰徳、葉名尻良、西田徹也、村田誠、清井仁
  • Organizer: 第77回日本血液学会学術集会
  • Place of Presentation: 石川県金沢市 石川県立音楽堂、ANAクラウンプラザホテル金沢、 ホテル日航金沢、ホテル金沢、金沢市アートホール、 もてなしドーム
  • Year and Date: 2015-10-16
• [Presentation] A phase I clinical trial of adoptive transfer of WT1 redirected T cells for refractory AML and MDS (2015)
  • Author(s): 藤原 弘、俵 功、谷本 一史、西田 徹也、村田 誠、寺倉 精太郎、糠谷 育衛、赤塚 美樹、岡本 昌隆、桝屋 正浩、池田 裕明、影山 慎一、恵美 宣彦、片山 直之、安川 正貴、珠玖 洋
  • Organizer: 第77回日本血液学会学術集会
  • Place of Presentation: 石川県金沢市 石川県立音楽堂、ANAクラウンプラザホテル金沢、 ホテル日航金沢、ホテル金沢、金沢市アートホール、 もてなしドーム
  • Year and Date: 2015-10-16
• [Presentation] 次世代シークエンサーを用いた臍帯血移植片拒絶症例におけるドナー反応性T細胞クローンの追跡 (2015)
  • Author(s): 葉名尻良、村田誠、宮尾康太郎、小山大輔、酒村玲央奈、後藤辰徳、渡邊慶介、寺倉精太郎、西田徹也、清井仁
  • Organizer: 第7回血液疾患免疫療法研究会学術集会
  • Place of Presentation: 東京都文京区 東京大学伊藤国際学術研究センター
  • Year and Date: 2015-09-26
• [Presentation] 抗原特異的T細胞の誘導における抗原提示細胞に発現するPD-L1の役割 (2015)
  • Author(s): 後藤辰徳、西田徹也、高木えり奈、宮尾康太郎、小山大輔、酒村玲央奈、葉名尻良、渡邊慶介、今橋伸彦、寺倉精太郎、村田誠、清井仁
  • Organizer: 第7回血液疾患免疫療法研究会学術集会
  • Place of Presentation: 東京都文京区 東京大学伊藤国際学術研究センター
  • Year and Date: 2015-09-26
• [Presentation] テトラサイクリンシステムを用いたCD19CARの発現コントロール (2015)
  • Author(s): 酒村玲央奈、寺倉精太郎、渡邊慶介、宮尾康太郎、小山大輔、後藤辰徳、葉名尻良、西田徹也、村田誠、清井仁
  • Organizer: 第7回血液疾患免疫療法研究会学術集会
  • Place of Presentation: 東京都文京区 東京大学伊藤国際学術研究センター
  • Year and Date: 2015-09-26
• [Patent(Industrial Property Rights)] Ｔ細胞機能向上のためのアダプター分子 (2016)
  • Inventor(s): 寺倉精太郎、清井仁、宮尾康太郎
  • Industrial Property Rights Holder: 名古屋大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2016-06-21
  • Overseas
• [Patent(Industrial Property Rights)] キメラ抗原レセプター遺伝子発現システム (2015)
  • Inventor(s): 寺倉精太郎、清井仁、酒村玲央奈
  • Industrial Property Rights Holder: 国立大学法人名古屋大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2015-099592
  • Filing Date: 2015-05-15