Quantitative assessment of TCR repertoire and allo-reactivity of human acute GVHD tissue-infiltrating T cells

• Project/Area Number: 15K09498
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: Nagoya University
• Principal Investigator: Murata Makoto 名古屋大学, 医学系研究科, 准教授 (40378063)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 造血幹細胞移植 / 移植片対宿主病 / T細胞 / 抗原 / HLA / T細胞受容体 / GVHD

Outline of Final Research Achievements

T cell repertoire was extremely skewed in human acute GVHD tissues. Two allo-reactive cytotoxic T cell clones were isolated from GVHD skin of a patient. Interestingly, their clonotypes were identical to the most and second most frequent clonotypes in the skin and accounted for almost all of the skin-infiltrating T cells. These results suggest that human acute GVHD can result from a few different allo-reactive cytotoxic T cell clones. In the analysis for 12 acute GVHD tissues, the frequent T cell clonotypes differed from tissue to tissue of the same patient, and the frequent T cell clonotypes in the same tissue differed from patient to patient. Importantly, there was an association between the low 1/Ds of GVHD tissue-infiltrating T cells and poor response to first-line steroid treatment, suggesting that evaluation of the degree of skewing of tissue-infiltrating T cells may allow us to establish a novel biomarker that predicts treatment response.

Research Products

• [Journal Article] High incidence of extensive chronic graft-versus-host disease in patients with the REG3A rs7588571 non-GG genotype (2017)
  • Author(s): Koyama Daisuke、Murata Makoto、Hanajiri Ryo、Okuno Shingo、Kamoshita Sonoko、Julamanee Jakrawadee、Takagi Erina、Hirano Daiki、Miyao Kotaro、Sakemura Reona、Goto Tatsunori、Hayakawa Fumihiko、Seto Aika、Ozawa Yukiyasu、Miyamura Koichi、Terakura Seitaro、Nishida Tetsuya、Kiyoi Hitoshi
  • Journal Title: PLoS One Volume: 12 Issue: 9 Pages: e0185213-e0185213
  • DOI: 10.1371/journal.pone.0185213
  • Peer Reviewed / Open Access
• [Journal Article] Safety and persistence of WT1-specific T-cell receptor gene-transduced lymphocytes in patients with AML and MDS. (2017)
  • Author(s): Tawara I, Kageyama S, Miyahara Y, Fujiwara H, Nishida T, Akatsuka Y, Ikeda H, Tanimoto K, Terakura S, Murata M, Inaguma Y, Masuya M, Inoue N, Kidokoro T, Okamoto S, Tomura D, Chono H, Nukaya I, Mineno J, Naoe T, Emi N, Yasukawa M, Katayama N, Shiku H.
  • Journal Title: Blood Volume: 130 Issue: 18 Pages: 1985-1994
  • DOI: 10.1182/blood-2017-06-791202
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impact of the presence of HLA 1-locus mismatch and the use of low-dose antithymocyte globulin in unrelated bone marrow transplantation. (2017)
  • Author(s): Kawamura K, Kanda J, Fuji S, Murata M, Ikegame K, Yoshioka K, Fukuda T, Ozawa Y, Uchida N, Iwato K, Sakura T, Hidaka M, Hashimoto H, Ichinohe T, Atsuta Y, Kanda Y.
  • Journal Title: Bone Marrow Transplantation Volume: 52 Issue: 10 Pages: 1390-1398
  • DOI: 10.1038/bmt.2017.153
  • Peer Reviewed
• [Journal Article] Phase II study of intrabone single unit cord blood transplantation for hematological malignancies (2017)
  • Author(s): Murata Makoto、Maeda Yoshinobu、Masuko Masayoshi、et.al
  • Journal Title: Cancer Science Volume: 108 Issue: 8 Pages: 1634-1639
  • DOI: 10.1111/cas.13291
  • Peer Reviewed / Open Access
• [Journal Article] GvHD prophylaxis after single-unit reduced intensity conditioning cord blood transplantation in adults with acute leukemia (2017)
  • Author(s): Terakura S, Kuwatsuka Y, Yamasaki S, Wake A, Kanda J, Inamoto Y, Mizuta S, Yamaguchi T, Uchida N, Kouzai Y, Aotsuka N, Ogawa H, Kanamori H, Nishiwaki K, Miyakoshi S, Onizuka M, Amano I, Fukuda T, Ichinohe T, Atsuta Y, Murata M, Teshima T
  • Journal Title: Bone Marrow Transplant Volume: 52 Issue: 9 Pages: 1261-1267
  • DOI: 10.1038/bmt.2017.116
  • NAID: 120006367975
  • Peer Reviewed
• [Journal Article] Impact of T-cell chimerism on relapse after cord blood transplantation for hematological malignancies: Nagoya Blood and Marrow Transplantation Group study (2017)
  • Author(s): Yokohata E, Kuwatsuka Y, Ohashi H, Terakura S, Kawashima N, Seto A, Kurahashi S, Ozawa Y, Goto T, Imahashi N, Nishida T, Miyao K, Sakemura R, Kato T, Sawa M, Kohno A, Sao H, Iida H, Kiyoi H, Naoe T, Miyamura K, Murata M
  • Journal Title: Bone Marrow Transplant. Volume: in press Issue: 4 Pages: 612-614
  • DOI: 10.1038/bmt.2016.323
  • Peer Reviewed
• [Journal Article] Impact of graft-versus-host disease on outcomes after unrelated cord blood transplantation. (2017)
  • Author(s): Kanda J, Morishima Y, Terakura S, Wake A, Uchida N, Takahashi S, Ono Y, Onishi Y, Kanamori H, Aotsuka N, Ozawa Y, Ogawa H, Sakura T, Ohashi K, Ichinohe T, Kato K, Atsuta Y, Teshima T, Murata M.
  • Journal Title: Leukemia Volume: 31(3) Issue: 3 Pages: 663-668
  • DOI: 10.1038/leu.2016.288
  • Peer Reviewed / Open Access
• [Journal Article] Exploratory research for optimal GvHD prophylaxis after single unit CBT in adults: short-term methotrexate reduced the incidence of severe GvHD more than mycophenolate mofetil. (2017)
  • Author(s): Terakura S, Wake A, Inamoto Y, Murata M, Sakai R, Yamaguchi T, Takahashi S, Uchida N, Onishi Y, Ohashi K, Ozawa Y, Kanamori H, Yamaguchi H, Fukuda T, Ichinohe T, Takanashi M, Atsuta Y, Teshima T.
  • Journal Title: Bone Marrow Transplant Volume: 52 Issue: 3 Pages: 423-430
  • DOI: 10.1038/bmt.2016.255
  • Peer Reviewed
• [Journal Article] GVHD after HLA-matched sibling BMT or PBSCT: Comparison of North American Caucasian and Japanese populations (2016)
  • Author(s): Kanda J, Brazauskas R, Hu Z, Kuwatsuka Y, Nagafuji K, Kanamori H, Kanda Y, Miyamura K, Murata M, Fukuda T, Sakamaki H, Kimura F, Seo S, Aljurf M, Yoshimi A, Milone G, Wood WA, Ustun C, Hashimi S, Pasquini M, Bonfim C, Dalal J, Hahn T, Atsuta Y, Saber W
  • Journal Title: Biol Blood Marrow Transplant Volume: 22 Issue: 4 Pages: 744-751
  • DOI: 10.1016/j.bbmt.2015.12.027
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A Tet-On Inducible System for Controlling CD19-Chimeric Antigen Receptor Expression upon Drug Administration (2016)
  • Author(s): Sakemura R, Terakura S, Watanabe K, Julamanee J, Takagi E, Miyao K, Koyama D, Goto T, Hanajiri R, Nishida T, Murata M, Kiyoi H
  • Journal Title: Cancer Immunol Res. Volume: 4 Issue: 8 Pages: 658-668
  • DOI: 10.1158/2326-6066.cir-16-0043
  • Peer Reviewed
• [Journal Article] Programmed Death-Ligand 1 on Antigen-presenting Cells Facilitates the Induction of Antigen-specific Cytotoxic T Lymphocytes: Application to Adoptive T-Cell Immunotherapy (2016)
  • Author(s): Goto T, Nishida T, Takagi E, Miyao K, Koyama D, Sakemura R, Hanajiri R, Watanabe K, Imahashi N, Terakura S, Murata M, Kiyoi H
  • Journal Title: J Immunother. Volume: 39 Issue: 8 Pages: 306-315
  • DOI: 10.1097/cji.0000000000000136
  • Peer Reviewed
• [Journal Article] Risk factors and prognosis of hepatic acute GvHD after allogeneic hematopoietic cell transplantation. (2016)
  • Author(s): Arai Y, Kanda J, Nakasone H, Kondo T, Uchida N, Fukuda T, Ohashi K, Kaida K, Iwato K, Eto T, Kanda Y, Nakamae H, Nagamura-Inoue T, Morishima Y, Hirokawa M, Atsuta Y, Murata M.
  • Journal Title: Bone Marrow Transplant Volume: 51 Issue: 1 Pages: 96-102
  • DOI: 10.1038/bmt.2015.205
  • Peer Reviewed
• [Journal Article] Influence of melphalan plus fludarabine-conditioning regimen in elderly patients aged >55 years with hematological malignancies. (2016)
  • Author(s): Miyao K, Sawa M, Kuwatsuka Y, Ozawa Y, Kato T, Kohno A, Sao H, Nishida T, Iida H, Naito K, Tsurumi H, Taji H, Mizuta S, Kusumoto S, Nakase K, Morishita Y, Kawashima N, Miyamura K, Murata M.
  • Journal Title: Bone Marrow Transplant Volume: 51 Issue: 1 Pages: 157-160
  • DOI: 10.1038/bmt.2015.235
  • Peer Reviewed
• [Journal Article] Bone marrow-derived mesenchymal stem cells (JR-031) for steroid-refractory grade III or IV acute graft-versus-host disease: a phase II/III study. (2016)
  • Author(s): Muroi K, Miyamura K, Okada M, Yamashita T, Murata M, Ishikawa T, Uike N, Hidaka M, Kobayashi R, Imamura M, Tanaka J, Ohashi K, Taniguchi S, Ikeda T, Eto T, Mori M, Yamaoka M, Ozawa K.
  • Journal Title: Int J Hematol Volume: 103 Issue: 2 Pages: 243-250
  • DOI: 10.1007/s12185-015-1915-9
  • Peer Reviewed
• [Journal Article] A comparison of tacrolimus and cyclosporine combined with methotrexate for graft-versus-host disease prophylaxis, stratified by stem cell source: a retrospective nationwide survey. (2016)
  • Author(s): Sakai R, Taguri M, Oshima K, Mori T, Ago H, Adachi S, Morita S, Taniguchi S, Fukuda T, Ohashi K, Eto T, Miyamura K, Iwato K, Kobayashi N, Kanamori H, Morishima Y, Nagamura-Inoue T, Sakamaki H, Atsuta Y, Murata M.
  • Journal Title: Int J Hematol Volume: 103 Issue: 3 Pages: 322-333
  • DOI: 10.1007/s12185-016-1939-9
  • Peer Reviewed
• [Journal Article] Impact of conditioning intensity and total body irradiation on acute graft-versus-host disease after hematopoietic cell transplantation. (2015)
  • Author(s): Nakasone N, Fukuda T, Kanda J, Mori T, Yano S, Kobayashi T, Miyamura K, Eto T, Kanamori H, Iwato K, Uchida N, Mori SI, Nagamura-Inoue T, Ichinohe T, Atsuta Y, Teshima T, Murata M.
  • Journal Title: Bone Marrow Transplant Volume: 50 Issue: 4 Pages: 559-65
  • DOI: 10.1038/bmt.2014.293
  • Peer Reviewed / Open Access
• [Journal Article] Prophylactic and therapeutic treatment of graft-versus-host disease in Japan. (2015)
  • Author(s): Murata M.
  • Journal Title: Int J Hematol Volume: 101 Issue: 5 Pages: 467-486
  • DOI: 10.1007/s12185-015-1784-2
  • Peer Reviewed
• [Journal Article] Chimerism status after unrelated donor bone marrow transplantation with fludarabine-melphalan conditioning is affected by the melphalan dose and is predictive of relapse. (2015)
  • Author(s): Imahashi N, Ohashi H, Terakura S, Miyao K, Sakemura R, Kato T, Sawa M, Yokohata E, Kurahashi S, Ozawa Y, Nishida T, Kiyoi H, Watamoto K, Kohno A, Kasai M, Kato C, Iida H, Naoe T, Miyamura K, Murata M
  • Journal Title: Ann Hematol. Volume: 94 Issue: 7 Pages: 1139-1148
  • DOI: 10.1007/s00277-015-2312-4
  • Peer Reviewed
• [Journal Article] Integration of humoral and cellular HLA-specific immune responses in cord blood allograft rejection. (2015)
  • Author(s): Hanajiri R, Murata M, Sugimoto K, Murase M, Sakemura R, Goto T, Watanabe K, Imahashi N, Terakura S, Ohashi H, Akatsuka Y, Kurahashi S, Miyamura K, Kiyoi H, Nishida T, Naoe T
  • Journal Title: Bone Marrow Transplant. Volume: 50 Issue: 9 Pages: 1187-1194
  • DOI: 10.1038/bmt.2015.119
  • Peer Reviewed
• [Journal Article] Age influences post-graft-versus-host disease non-relapse mortality in adults with acute graft-versus-host disease of varying severity following allogeneic hematopoietic cell transplant. (2015)
  • Author(s): Nakane T, Fukuda T, Kanda J, Taniguchi S, Eto T, Ohashi K, Nakamae H, Kurokawa M, Mori T, Morishima Y, Nagamura-Inoue T, Sakamaki H, Atsuta Y, Murata M.
  • Journal Title: Leuk Lymphoma Volume: 56 Issue: 8 Pages: 2392-2397
  • DOI: 10.3109/10428194.2015.1009056
  • Peer Reviewed
• [Presentation] High incidence of extensive chronic GVHD in patients with the REG3A rs7588571 non-GG genotype. (2018)
  • Author(s): Murata M, Koyama D, Hanajiri R, Okuno S, Kamoshita S, Julamanee J, Takagi E, Hirano D, Miyao K, Sakemura R, Goto T, Hayakawa F, Seto A, Ozawa Y, Miyamura K, Terakura S, Nishida T, Kiyoi H.
  • Organizer: 2018 BMT Tandem Meetings
  • Int'l Joint Research
• [Presentation] HSCTの課題克服に向けて ～GVHD制御の観点から～. (2018)
  • Author(s): 村田 誠
  • Organizer: 第40回日本造血細胞移植学会総会
  • Invited
• [Presentation] ステロイド抵抗性急性GVHDに対するヒト骨髄由来間葉系幹細胞治療：単一施設における後方視的検討. (2017)
  • Author(s): 村田 誠、松下 正、後藤辰徳、入山智沙子、寺倉精太郎、西田徹也、清井 仁.
  • Organizer: 第16回日本再生医療学会総会
  • Place of Presentation: 仙台国際センター（宮城県、仙台市）
  • Year and Date: 2017-03-07
• [Presentation] 造血幹細胞移植における間葉系幹細胞の臨床応用. (2017)
  • Author(s): 村田 誠.
  • Organizer: 第39回日本造血細胞移植学会総会
  • Place of Presentation: くにびきメッセ（島根県、松江市）
  • Year and Date: 2017-03-02
  • Invited
• [Presentation] Quantitative assessment of TCR repertoire and allo-reactivity of human acute GVHD tissue-infiltrating T cells. (2017)
  • Author(s): Koyama D, Murata M, Hanajiri R, Okuno S, Kamoshita S, Takagi E, Julamanee J, Miyao K, Sakemura R, Goto T, Terakura S, Nishida T, Kiyoi H.
  • Organizer: The 59th annual meeting of the American Society of Hematology
  • Int'l Joint Research
• [Presentation] The Synergistic T-Cell Signal By CD79A/CD40 Costimulatory Endodomain Enhances CD19 Chimeric Antigen Receptor T-Cell Proliferation and Survival. (2017)
  • Author(s): Julamanee J, Terakura S, Sakemura R, Miyao K, Okuno S, Kamoshita S, Takagi E, Koyama D, Goto T, Hanajiri R, Nishida T, Murata M, Kiyoi H.
  • Organizer: The 59th annual meeting of the American Society of Hematology
  • Int'l Joint Research
• [Presentation] Improvement of antigen-specific CTL persistence by transduction of novel artificial adapter molecule. (2017)
  • Author(s): Miyao K, Watanabe K, Terakura S, Hamana H, Kishi H, Nishida T, Murata M, Kiyoi H.
  • Organizer: The 8th JSH International Symposium 2017
  • Int'l Joint Research
• [Presentation] ヒト急性GVHDにおける組織浸潤アロ反応性T細胞レパトアの定量的評価. (2017)
  • Author(s): 小山大輔、村田 誠、葉名尻 良、奥野真吾、鴨下園子、高木えり奈、Jakrawadee Julamanee、宮尾康太郎、後藤辰徳、酒村玲央奈、寺倉精太郎、西田徹也、清井 仁.
  • Organizer: 第79回日本血液学会学術集会
• [Presentation] 急性白血病に対する減量前治療を用いた臍帯血移植におけるGVHD予防法の比較研究. (2017)
  • Author(s): 寺倉精太郎、鍬塚八千代、山崎 聡、和氣 敦、諫田淳也、稲本賢弘、水田秀一、山口拓洋、内田直之、香西康司、青墳信之、小川啓恭、金森平和、西脇嘉一、宮腰重三郎、鬼塚真仁、天野逸人、福田隆浩、一戸辰夫、熱田由子、村田 誠、豊嶋崇徳.
  • Organizer: 第79回日本血液学会学術集会
• [Presentation] 新規人工アダプター分子の遺伝子導入は抗原特異的CTLのpersistenceを向上させる. (2017)
  • Author(s): 宮尾康太郎、寺倉精太郎、奥野真吾、渡邊慶介、浜名 洋、岸 裕幸、酒村玲央奈、Jakrawadee Julamanee、後藤辰徳、西田徹也、村田 誠、清井 仁.
  • Organizer: 第9回血液疾患免疫療法学会学術集会
• [Presentation] Intrabone transplantation of a single cord blood unit using non-irradiated reduced-intensity conditioning. (2016)
  • Author(s): Murata M, Maeda Y, Masuko M, Onishi Y, Endo T, Terakura S, Ishikawa Y, Iriyama C, Ushijima Y, Goto T, Fujii N, Tanimoto M, Kobayashi H, Shibasaki Y, Fukuhara N, Inamoto Y, Suzuki R, Matsushita T, Kodera Y, Kiyoi H, Naoe T, Nishida T.
  • Organizer: The 58th annual meeting of the American Society of Hematology
  • Place of Presentation: San Diego (USA)
  • Year and Date: 2016-12-02
  • Int'l Joint Research
• [Presentation] 急性GVHDの治療. (2016)
  • Author(s): 村田 誠.
  • Organizer: 第78回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県、横浜市）
  • Year and Date: 2016-10-13
  • Invited
• [Presentation] Low-dose thymoglobulin as second-line treatment for steroid-resistant acute GVHD: a JSHCT analysis. (2016)
  • Author(s): Murata M, Ikegame K, Morishita Y, Ogawa H, Nakamae H, Ikeda T, Nishida T, Inoue M, Eto T, Ichinohe T, Atsuta Y, Teshima T.
  • Organizer: 第78回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県、横浜市）
  • Year and Date: 2016-10-13
• [Presentation] Adoptive transfer of WT1-specific TCR-gene-transduced T lymphocytes in patients with hematological malignancies. (2016)
  • Author(s): 俵 功、藤原 弘、村田 誠、赤塚美樹、西田徹也、寺倉精太郎、恵美宣彦、桝屋正浩、池田裕明、片山直之、安川正貴、影山慎一、珠玖 洋.
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川県、横浜市）
  • Year and Date: 2016-10-06
• [Presentation] ヒトGVHD組織におけるアロ反応性T細胞の解析. (2016)
  • Author(s): 小山大輔、村田 誠、奥野真吾、鴨下園子、Jakrawadee Julamanee、高木えり奈、宮尾康太郎、後藤辰徳、酒村玲央奈、葉名尻 良、寺倉精太郎、西田徹也、清井 仁.
  • Organizer: 第8回血液疾患免疫療法学会学術集会
  • Place of Presentation: 北海道大学医学部（北海道、札幌市）
  • Year and Date: 2016-09-02
• [Presentation] A new strategy to control CD19 CAR; regulation under tetracycline-inducible system allows on-demand CD19 CAR expression and disappearance. (2016)
  • Author(s): 酒村玲央奈、寺倉精太郎、Jakrawadee Julamanee、宮尾康太郎、西田徹也、村田 誠、清井 仁.
  • Organizer: 第7回日本血液学会国際シンポジウム
  • Place of Presentation: 淡路夢舞台国際カンファレンスセンター（兵庫県、淡路市）
  • Year and Date: 2016-05-13
  • Int'l Joint Research
• [Presentation] 間葉系幹細胞を用いたGVHD治療. (2016)
  • Author(s): 村田 誠.
  • Organizer: 第64回日本輸血・細胞治療学会総会
  • Place of Presentation: 国立京都国際会館（京都府、京都市）
  • Year and Date: 2016-04-28
• [Presentation] Potential value of low-dose ATG treatment for steroid-resistant acute GVHD. (2016)
  • Author(s): Murata M, Ikegame K, Ogawa H, Nakamae H, Ikeda T, Nishida T, Inoue M, Eto T, Ichinohe T, Atsuta Y, Teshima T, Morishita Y.
  • Organizer: 2016 BMT Tandem Meetings
  • Place of Presentation: Honolulu (USA)
  • Year and Date: 2016-02-18
  • Int'l Joint Research
• [Presentation] Adoptive transfer of WT1-specific TCR gene-transduced lymphocytes in patients with myelodysplastic syndrome and acute myeloid leukemia. (2015)
  • Author(s): Tawara I, Masuya M, Kageyama S, Nishida T, Terakura S, Murata M, Fujiwara H, Akatsuka Y, Ikeda H, Miyahara Y, Tomura D, Nukaya I, Takesako K, Emi N, Yasukawa M, Katayama N, Shiku H.
  • Organizer: 57th ASH Annual Meeting and Exposition
  • Place of Presentation: Orlando (USA)
  • Year and Date: 2015-12-04
  • Int'l Joint Research
• [Presentation] A phase 1/2 study of WT1 peptide cancer vaccine WT4869 in patients with myelodysplastic syndromes (MDS). (2015)
  • Author(s): Suzuki T, Ueda Y, Ogura M, Uchida T, Ozawa K, Miyakoshi S, Naoe T, Murata M, Kizaki M, Uike N, Abe Y, Hidaka M, Tagashira S, Tsuchiya S, Ohyashiki K, Miyazaki Y.
  • Organizer: 57th ASH Annual Meeting and Exposition
  • Place of Presentation: Orlando (USA)
  • Year and Date: 2015-12-04
  • Int'l Joint Research
• [Presentation] A novel strategy of switching on/off CD19CAR expression under Tetracycline based system. (2015)
  • Author(s): Sakemura R, Terakura S, Watanabe K, Miyao K, Koyama D, Goto T, Hanajiri R, Nishida T, Murata M, Kiyoi H.
  • Organizer: 57th ASH Annual Meeting and Exposition
  • Place of Presentation: Orlando (USA)
  • Year and Date: 2015-12-04
  • Int'l Joint Research
• [Presentation] PD-L1 on Antigen-Presenting Cells Facilitate the Induction of Antigen-Specific Cytotoxic T Lymphocytes. (2015)
  • Author(s): Goto T, Nishida T, Miyao K, Koyama D, Sakemura R, Hanajiri R, Watanabe K, Imahashi N, Terakura S, Murata M, Kiyoi H.
  • Organizer: 57th ASH Annual Meeting and Exposition
  • Place of Presentation: Orlando (USA)
  • Year and Date: 2015-12-04
  • Int'l Joint Research
• [Presentation] Detecting donor-reactive T cell clones involved in cord blood allograft rejection. (2015)
  • Author(s): Murata M, Hanajiri R, Koyama D, Miyao K, Sakemura R, Goto T, Watanabe K, Terakura S, Nishida T, Kiyoi H.
  • Organizer: The 20th annual congress of Asia-Pacific Blood and Marrow Transplantation Group
  • Place of Presentation: 万国津梁館（沖縄県、名護市）
  • Year and Date: 2015-10-30
  • Int'l Joint Research
• [Presentation] Roles of PD-L1 on antigen-presenting cells for the generation of antigen-specific T cells. (2015)
  • Author(s): 後藤辰徳, 西田徹也, 高木えり奈, 宮尾康太郎, 小山大輔, 酒村玲央奈, 葉名尻 良, 渡邊慶介, 今橋伸彦, 寺倉精太郎, 村田 誠, 清井 仁.
  • Organizer: 第77回日本血液学会学術集会
  • Place of Presentation: 石川県立音楽堂、他（石川県、金沢市）
  • Year and Date: 2015-10-16
• [Presentation] Inducible CD19 CAR expression under tetracycline-based regulation system. (2015)
  • Author(s): 酒村玲央奈, 寺倉精太郎, 渡邊慶介, 宮尾康太郎, 小山大輔, 後藤辰徳, 葉名尻 良, 西田徹也, 村田 誠, 清井 仁.
  • Organizer: 第77回日本血液学会学術集会
  • Place of Presentation: 石川県立音楽堂、他（石川県、金沢市）
  • Year and Date: 2015-10-16
• [Presentation] Tracking donor-reactive T cell clones by deep sequencing in cord blood allograft rejection. (2015)
  • Author(s): 葉名尻 良, 村田 誠, 宮尾康太郎, 小山大輔, 酒村玲央奈, 後藤辰徳, 渡邊慶介, 寺倉精太郎, 西田徹也, 清井 仁.
  • Organizer: 第77回日本血液学会学術集会
  • Place of Presentation: 石川県立音楽堂、他（石川県、金沢市）
  • Year and Date: 2015-10-16
• [Presentation] 急性GVHDの予防. (2015)
  • Author(s): 村田 誠.
  • Organizer: 第77回日本血液学会学術集会
  • Place of Presentation: 石川県立音楽堂、他（石川県、金沢市）
  • Year and Date: 2015-10-16
  • Invited
• [Book] 血液科研修ノート (2016)
  • Author(s): 村田 誠、他（105名）
  • Total Pages: 533
  • Publisher: 診断と治療社
• [Book] 骨髄線維症 (2016)
  • Author(s): 村田 誠、他（23名）
  • Total Pages: 187
  • Publisher: 医薬ジャーナル社
• [Book] 白血病学（下） (2016)
  • Author(s): 村田 誠、他（95名）
  • Total Pages: 582
  • Publisher: 日本臨床社
• [Book] 今日の治療指針2016 (2016)
  • Author(s): 村田 誠（多数で共著）
  • Total Pages: 2096
  • Publisher: 医学書院
• [Patent(Industrial Property Rights)] 脂肪組織由来間葉系幹細胞を用いた臍帯血造血幹細胞支持物 (2016)
  • Inventor(s): 中山享之、村田 誠、加藤栄史
  • Industrial Property Rights Holder: 名古屋大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-167355
  • Filing Date: 2016-08-29