| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
T cell repertoire was extremely skewed in human acute GVHD tissues. Two allo-reactive cytotoxic T cell clones were isolated from GVHD skin of a patient. Interestingly, their clonotypes were identical to the most and second most frequent clonotypes in the skin and accounted for almost all of the skin-infiltrating T cells. These results suggest that human acute GVHD can result from a few different allo-reactive cytotoxic T cell clones. In the analysis for 12 acute GVHD tissues, the frequent T cell clonotypes differed from tissue to tissue of the same patient, and the frequent T cell clonotypes in the same tissue differed from patient to patient. Importantly, there was an association between the low 1/Ds of GVHD tissue-infiltrating T cells and poor response to first-line steroid treatment, suggesting that evaluation of the degree of skewing of tissue-infiltrating T cells may allow us to establish a novel biomarker that predicts treatment response.
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