| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
A recombinant HSV-1, T-01, killed 16 out of 21 human cell lines of hematological malignancies. Positive correlations were observed among the expression levels of HSV-1 receptor nectin-1, entry of T-01, and cytotoxicity. In accord with it, knockdown of nectin-1 decreased entry of T-01, and forced expression of nectin-1 induced cytotoxic activity.
These data indicate that viral entry via nectin-1 is a determining factor of cytotoxicity by oncolytic HSV-1 against hematological malignancies, and that the expression of nectin-1 is a biomarker of the susceptibility of hematological malignancies to HSV-1.
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