| Project/Area Number |
15K09508
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
佐藤 勉 札幌医科大学, 医学部, 講師 (40404602)
小船 雅義 札幌医科大学, 医学部, 准教授 (90336389)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | GVHD / Treg / 高次元サイトメトリー / 高次元サイトメトリー法 / BH3 profiling |
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| Outline of Final Research Achievements |
In chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation, individual differences in severity are large, so identification of GVHD predictive factors and development of a novel control method are desired.
In this study, we comprehensively analyzed cGVHD regulatory cells after transplantation by using high-dimensional cytometry in combination with BH3 profiling and clarified the usefulness of IL-2 therapy.
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