| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Not only IFN-g which is Th1 cytokine but also IL-4 and IL-13 which are Th2 cytokine enhance the IL-12 production from a dendritic cell. IFN-g reinforces both the IL-12 production from DC and the IL-23 production. On the other hand, IL-4 and IL-13 reinforce the IL-12 production from DC, but the IL-23 production controls it.
IL-10 controls IL-12/23/27 production from DC. IL-10 controls dendritic cell cytokine-producing reinforcement action of IFN-g/IL-4/IL-13.
The cytokine-producing ability of the immature dendritic cell is inferior to a mature dendritic cell, but still is enough quantity for a T cell differentiation increase instruction.
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