Inflammatory monocyoid expression and epitope cloning of immunoglobulin in patients with IgG4-related disease
Project/Area Number |
15K09510
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Hematology
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Research Institution | Kanazawa Medical University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
河南 崇典 金沢医科大学, 医学部, 講師 (20350762)
中村 拓路 金沢医科大学, 医学部, 助教 (90725003)
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Research Collaborator |
ITOH Kunihiko 静岡県立大学
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Project Period (FY) |
2015-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 濾胞樹状細胞 / CD14 / リンパ濾胞形成 / ファージディスプレイ / ランダムペプチドライブラリー / 多クローン性高ガンマグロブリン血症 / 多施設共同研究 / 多施設共同前方視研究 / CD21 / 多クローン性高γグロブリン血症 / 炎症性単球 |
Outline of Final Research Achievements |
We conducted a multicenter phase II prospective clinical trial of glucocorticoid for patients with untreated IgG4-related disease. Of the 44 patients with definite IgG4-RD, 29 (65.9%) achieved CR, and the ORR was 93.2%. No patient was refractory to primary treatment. By phage displayed random peptide assay, we got 8 clone that react to patients' serum, however further analysis of reactive clone was failed. Pathological findings of tissue samples from patients with IgG4-RD (N= 22), reactive hyperplasia (N=3), multicentric Castleman’s disease (N=3), and Sjogren’s syndrome (N = 13) were analyzed. CD14-positive lymphoid follicles were observed only in patients with IgG4-RD, and CD14-positive cells were identified as follicular dendritic cells by multicolor immunohistochemistry.The presence of CD14+ follicular dendritic cells in lymphoid follicles may play a pathophysiological role in IgG4-RD.
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Academic Significance and Societal Importance of the Research Achievements |
IgG4関連疾患は21世紀に入り日本より発信された疾患であるが、鑑別診断が極めて重要であり、診断さえ確実であれば中等量ステロイド治療が有効である事が示された。 また、IgG4関連疾患の病因病態として近年幾つかの自己抗原が同定されてはいるが、それだけで全ての本疾患の病態を説明するのは不可能である。増加している多クローン性のガンマグロブリンの反応エピトープが判明すれば別な意味での病因論が展開できる。 また本疾患においてCD14陽性濾胞樹状細胞が組織の病態形成において重要な可能性が示され、ここを標的とした治療の開発も期待できる。
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Report
(5 results)
Research Products
(27 results)
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[Journal Article] Tentative diagnostic criteria and disease severity classification for Castleman disease: A report of the research group on Castleman disease in Japan.2018
Author(s)
Fujimoto S, Koga T, Kawakami A, Kawabata H, Okamoto S, Mizuki M, Yano S, Ide M, Uno K, Yagi K, Kojima T, Mizutani M, Tokumine Y, Nishimoto N, Fujiwara H, Nakatsuka SI, Shiozawa K, Iwaki N, Masaki Y, Yoshizaki K.
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Journal Title
Mod Rheumatol
Volume: 28
Issue: 1
Pages: 161-167
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A Host-Dependent Prognostic Model for Elderly Patients with Diffuse Large B-Cell Lymphoma.2017
Author(s)
Miura K, Konishi J, Miyake T, Makita M, Hojo A, Masaki Y, Uno M, Ozaki J, Yoshida C, Niiya D, Kitazume K, Maeda Y, Takizawa J, Sakai R, Yano T, Yamamoto K, Sunami K, Hiramatsu Y, Kazutoshi Aoyama, Tsujimura H, Murakami J, Hatta Y, Kanno M.
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Journal Title
Oncologist
Volume: 22
Issue: 5
Pages: 554-560
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The Standard International Prognostic Index for Predicting the Risk of CNS Involvement in DLBCL without Specific Prophylaxis.2017
Author(s)
Tomita N, Yokoyama M, Yamamoto W, Watanabe R, Shimazu Y, Masaki Y, Tsunoda S, Hashimoto C, Murayama K, Yano T, Okamoto R, Kikuchi A, Tamura K, Sato K, Sunami K, Shibayama H, Takimoto R, Ohshima R, Takahashi H, Moriuchi Y, Kinoshita T, Yamamoto M, Numata A, Nakajima H, Miura I, Takeuchi K.
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Journal Title
Leuk Lymphoma
Volume: 59
Issue: 1
Pages: 1-8
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A multicenter phase II prospective clinical trial of glucocorticoid for patients with untreated IgG4-related disease.2016
Author(s)
Masaki Y, Matsui S, Saeki T, Tsuboi H, Dobashi H, Susaki K, Morimoto H, Takagi K, Kawano M, Origuchi T, Wada Y, Takahashi N, Horikoshi M, Ogishima, H, Suzuki Y, Kawanami T, Kawanami (Iwao) H, Sakai T, Suzuki R, Morikawa Y, Yoshino T, Nakamura S, Kojima M, Kurose N, Sugai S, Sumida T.
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Journal Title
Mod Rheumatol
Volume: 15
Issue: 5
Pages: 1-6
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Proposed diagnostic criteria, disease severity classification and treatment strategy for TAFRO syndrome, 2015 version.2016
Author(s)
Masaki Y, Kawabata H, Takai K, Kojima M, Tsukamoto N, Ishigaki Y, Kurose N, Ide M, Murakami J, Nara K, Yamamoto H, Ozawa Y, Takahashi H, Miura K, Miyauchi T, Yoshida S, Momoi A, Awano N, Ikushima S, Ohta Y, Furuta N, Fujimoto S, Kawanami H, Sakai T, Kawanami T, Fujita Y, Fukushima T, Nakamura S, Kinoshita T, Aoki S.
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Journal Title
Int J Hematol.
Volume: in press
Issue: 6
Pages: 686-92
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] <b>CD14</b><sup><b>+</b></sup><b> follicular dendritic cells in lymphoid follicles may play a role in the pathogenesis of IgG4-related </b><b>disease </b>2015
Author(s)
Tomomi Satoh-Nakamura, Nozomu Kurose, Takafumi Kawanami, Takuji Nakamura, Haruka Iwao-Kawanami, Akio Nakajima, Miyuki Miki, Tomoyuki Sakai, Yoshimasa Fujita, Masao Tanaka, Toshihiro Fukushima, and Yasufumi Masaki
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Journal Title
Biomedical Research
Volume: 36
Issue: 2
Pages: 143-153
DOI
NAID
ISSN
0388-6107, 1880-313X
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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