Research Project
Grant-in-Aid for Scientific Research (C)
The immunomodulation-related gene polymorphism analysis of patients who received allogeneic bone marrow transplantation and their donor showed that the polymorphic sites of functional genes with clinical significance, including NKG 2D, CXCL10, NLRP 3, THBD/BDCA3, TLR1, TLR4, CCL2, were concentrated in the 5’-untranslated region. It was also revealed that miRNA-1245 binds to the polymorphic site of the 5’-untranslated region of the activated NK receptor gene NKG2D, leading to suppress NK activity, and that miRNA-1245 in serum exosomes obtained from patients with hematologic malignancies is increased. Moreover, the binding ability of miRNA-1245 with the low NK cytotoxicity genotype was superior to that with the high NK cytotoxicity genotype.
All 2018 2017 2016 2015 2014
All Journal Article (27 results) (of which Int'l Joint Research: 2 results, Peer Reviewed: 27 results, Acknowledgement Compliant: 7 results, Open Access: 8 results) Presentation (10 results) (of which Int'l Joint Research: 10 results)
Int J Hematol
Volume: 107 Issue: 5 Pages: 513-518
10.1007/s12185-018-2412-8
Volume: 107 Issue: 1 Pages: 105-111
10.1007/s12185-017-2323-0
Leuk Lymphoma
Volume: 58 Issue: 5 Pages: 1061-1067
10.1080/10428194.2016.1231406
Ann Hematol
Volume: 96 Issue: 2 Pages: 289-297
10.1007/s00277-016-2872-y
Oncotarget
Volume: 8 Issue: 28 Pages: 45670-45686
10.18632/oncotarget.17315
Cancer Lett
Volume: 400 Pages: 127-136
10.1016/j.canlet.2017.04.027
Transfusion
Volume: 未定 Issue: 5 Pages: 1242-3
10.1111/trf.13507
BMT (in press)
Volume: NA Issue: 5 Pages: 645-53
10.1038/bmt.2015.349
Transpl Immunol
Volume: 38 Pages: 60-6
10.1016/j.trim.2016.06.002
Scientific Reports
Volume: 6 Issue: 1 Pages: 30779-30781
10.1038/srep30779
Volume: 7 Issue: 32 Pages: 52517-52529
10.18632/oncotarget.9593
Leuk Res
Volume: 47 Pages: 47-53
10.1016/j.leukres.2016.04.017
120005830648
Sci Rep
Volume: 6 Issue: 1 Pages: 39231-39231
10.1038/srep39231
Bone Marrow Transplantation
Volume: 51 Issue: 4 Pages: 604-606
10.1038/bmt.2015.297
Am J Hematol
Volume: 91 Issue: 3 Pages: 302-307
10.1002/ajh.24270
Bone Marrow Transplant
Volume: 51 Issue: 3 Pages: 451-3
10.1038/bmt.2015.268
Eur J Haematol
Volume: NA Issue: 3 Pages: 278-287
10.1111/ejh.12723
PloS One
Volume: - Issue: 4 Pages: e0120709-e0120709
10.1371/journal.pone.0120709
Volume: 102 Issue: 4 Pages: 460-70
10.1007/s12185-015-1852-7
Volume: NA Issue: 2 Pages: 295-300
10.1007/s00277-015-2536-3
Volume: 102 Issue: 5 Pages: 569-78
10.1007/s12185-015-1859-0
Biol Blood Marrow Transplant
Volume: 21 Issue: 9 Pages: 1632-40
10.1016/j.bbmt.2015.05.009
Journal of Clinical and Experimental Hematopathology
Volume: 55 Issue: 2 Pages: 89-96
10.3960/jslrt.55.89
130005104661
Integr Mol Med
Volume: 2 Issue: 6 Pages: 405-413
10.15761/imm.1000177
Blood
Volume: 126 Issue: 3 Pages: 415-22
10.1182/blood-2015-04-642652
J Hematol Oncol
Volume: 8 Issue: 1 Pages: 102-102
10.1186/s13045-015-0201-x
120005672589
Eur J Haemat
Volume: 18 Issue: 3 Pages: 230-238
10.1111/ejh.12484
120005661927