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Pathogenetic relevance of inflammatory cytokines and autoimmunity in arthritis

Research Project

Project/Area Number 15K09518
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Collagenous pathology/Allergology
Research InstitutionUniversity of Tsukuba

Principal Investigator

Matsumoto Isao  筑波大学, 医学医療系, 准教授 (30343081)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords関節リウマチ
Outline of Final Research Achievements

We analyzed the expression and the function of six-transmembrane epithelial antigen 4 (STEAP4) and its exon3 spliced variant in human monocytes, and identified specific expression and relation to CRP in patients with rheumatoid arthritis (RA). To reveal the function of STEAP4 and its variant, we established overexpressed THP-1 cell line, and proved that IL-6 was significantly downregulated by LPS stimulation in exon3 variant-overexpressed lines, with the change of NF-kB and STAT3 pathways. These findings suggest that STEAP4 variants also have pivotal role controlling inflammatory cytokines in RA.
In addition, anti-citrullinated GPI-peptide 7 antibodies were specifically decreased by 3 kinds of effective biological treatment in patients with RA, suggesting one of the new biomarkers reflecting disease activity in RA.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (8 results)

All 2018 2017 2016 2015 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Acknowledgement Compliant: 4 results) Presentation (1 results) (of which Invited: 1 results) Remarks (1 results)

  • [Journal Article] Clinical and functional significance of STEAP4-splice variant in CD14+ monocytes in patients with rheumatoid arthritis.2018

    • Author(s)
      136.Ebe H, *Matsumoto I, Kawaguchi H, Kurata I, Tanaka Y, Inoue A, Kondo Y, Tsuboi H, Sumida T
    • Journal Title

      Clin Exp Immunol

      Volume: 191 Pages: 338-348

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-cyclic citrullinated glucose-6-phosphate isomerase peptide -7 (CCG-7) antibodies were suppressed by biologics treatment and deposited to citrullinated proteins in CD68-positive cells in the RA synovium.2017

    • Author(s)
      132.Umeda N, *Matsumoto I, Tanaka Y, Kawaguchi H, Ebe H, Kagami Y, Ishigami A, Sumida T
    • Journal Title

      Mod Rheumatol.

      Volume: 27 Pages: 914-916

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-cyclic citrullinated glucose-6-phosphate isomerase peptide -7 (CCG-7) antibodies were suppressed by biologics treatment and deposited to citrullinated proteins in CD68-positive cells in the RA synovium.2017

    • Author(s)
      131.Umeda N, *Matsumoto I, Tanaka Y, Kawaguchi H, Ebe H, Kagami Y, Ishigami A, Sumida T
    • Journal Title

      Mod Rheumatol.

      Volume: in press

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] TIARP attenuates autoantibody-mediated arthritis via the suppression of neutrophil migration by reducing CXCL2/CXCR2 and IL-6 expression.2016

    • Author(s)
      125.Inoue A, *Matsumoto I, Tanaka Y, Umeda N, Takai C, Kawaguchi H, Ebe H, Yoshida H, Matsumoto Y, Segawa S, Takahashi S, Sumida T.
    • Journal Title

      Sci Rep 6:38684, 2016

      Volume: 6 Pages: 38684-38684

    • NAID

      120007135255

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Prevalence of soluble peptidylarginine deiminase 4 (PAD4) and anti-PAD4 antibodies in autoimmune diseases.2016

    • Author(s)
      Umeda N, *Matsumoto I, Kawaguchi H, Kurashima Y, Kondo Y, Tsuboi H, Ogishima H, Suzuki T, Kagami Y, Sakyu T, Ishigami A, Maruyama N, Sumida T.
    • Journal Title

      Clin Rheumatol

      Volume: in press

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Specific overexpression of TNFAIP9 in CD14+CD16- monocytes in patients with rheumatoid arthritis- Comparative analysis with TNFAIP3.2015

    • Author(s)
      Takai C, *Matsumoto I, Inoue A, Umeda N, Tanaka Y, Kurashima Y, Wada Y, Narita I, Sumida T.
    • Journal Title

      Clin Exp Immunol

      Volume: 180 Pages: 458-466

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Pathogenic autoimmune reaction and new therapeutic avenue of rheumatoid arthritis2017

    • Author(s)
      松本 功
    • Organizer
      第46回日本免疫学会学術集会クリニカルセミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Remarks] 筑波大学医学医療系内科 膠原病・リウマチ・アレルギー

    • URL

      http://www.md.tsukuba.ac.jp/clinical-med/rheumatology/

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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