Detection of biomarkers in pre-treatment serum which predict the clinical remission on the treatment with biologics in rheumatoid arthritis.
| Project/Area Number |
15K09524
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | バイオマーカー / 治療効果予測 / 関節リウマチ / トシリズマブ / インフリキマム / 免疫学 |
|---|
| Outline of Final Research Achievements |
Rapid progress of RA therapy has been made with molecular inhibitors.However simultaneously, many kinds of biologics were developed, then it has been difficult to select the adequate biologic by both physicians and patients. Therefore we try to detect the makers in serum before starting therapy which can predict the actual efficacy of biologics.
In result, in the case of anti TNF-α inhibitor therapy, the efficacy has been able to predicted on the statistical analysis using Lasso method.Now we know the individual efficacy by selected biologic.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Tentative diagnostic criteria and disease severity classification for Castleman disease: A report of the research group on Castleman disease in Japan.2017
Author(s)
Fujimoto S, Koga T, Kawakami A, Kawabata H, Okamoto S, Mizuki M, Yano S, Ide M, Uno K, Yagi K, Kojima T, Mizutani M, Tokumine Y, Nishimoto N, Fujiwara H, Nakatsuka SI, Shiozawa K, Iwaki N, Masaki Y, Yoshizaki K.
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Journal Title
Mod Rheumatol.
Volume: 7
Pages: 1-7
Related Report
Peer Reviewed / Open Access
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[Journal Article] A reference guide for management of Castleman disease2017
Author(s)
吉崎和幸, 岡本真一郎,川端浩, 水木満佐央, 川上純, 正木康史, 矢野真吾, 井出眞, 宇野賀津子, 八木克巳, 小島俊行, 水谷実, 徳嶺進洋, 西本憲弘, 藤原寛, 中塚伸一, 塩沢和子, 岩城憲子, 古賀智裕
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Journal Title
Rinsho Ketsueki
Volume: 58
Issue: 2
Pages: 97-107
DOI
NAID
ISSN
0485-1439, 1882-0824
Related Report
Peer Reviewed / Open Access
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