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Detection of biomarkers in pre-treatment serum which predict the clinical remission on the treatment with biologics in rheumatoid arthritis.

Research Project

Project/Area Number 15K09524
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Collagenous pathology/Allergology
Research InstitutionOsaka University

Principal Investigator

Yoshizaki Kazuyuki  大阪大学, 産業科学研究所, 特任教授 (90144485)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsバイオマーカー / 治療効果予測 / 関節リウマチ / トシリズマブ / インフリキマム / 免疫学
Outline of Final Research Achievements

Rapid progress of RA therapy has been made with molecular inhibitors.However simultaneously, many kinds of biologics were developed, then it has been difficult to select the adequate biologic by both physicians and patients. Therefore we try to detect the makers in serum before starting therapy which can predict the actual efficacy of biologics.
In result, in the case of anti TNF-α inhibitor therapy, the efficacy has been able to predicted on the statistical analysis using Lasso method.Now we know the individual efficacy by selected biologic.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (13 results)

All 2018 2017 2016 2015

All Journal Article (7 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results,  Open Access: 6 results) Presentation (5 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results) Funded Workshop (1 results)

  • [Journal Article] The Role of Interleukin-6 in Castleman Disease. Castleman Disease.2018

    • Author(s)
      Yoshizaki K, Murayama S, Ito H, Koga T.
    • Journal Title

      Hematology/Oncology Clinics of North America.

      Volume: 32(1) Issue: 1 Pages: 23-36

    • DOI

      10.1016/j.hoc.2017.09.003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tentative diagnostic criteria and disease severity classification for Castleman disease: A report of the research group on Castleman disease in Japan.2017

    • Author(s)
      Fujimoto S, Koga T, Kawakami A, Kawabata H, Okamoto S, Mizuki M, Yano S, Ide M, Uno K, Yagi K, Kojima T, Mizutani M, Tokumine Y, Nishimoto N, Fujiwara H, Nakatsuka SI, Shiozawa K, Iwaki N, Masaki Y, Yoshizaki K.
    • Journal Title

      Mod Rheumatol.

      Volume: 7 Pages: 1-7

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] RA治療効果予測マーカーの探索(Detection of Prediction markers on the onset for RA therapy)2017

    • Author(s)
      吉崎和幸, 宇野賀津子, 岩橋充啓, 山名二郎, 山名征三, 八木克巳
    • Journal Title

      アレルギーの臨床(The Allergy in Practice)

      Volume: 35(5)No.499 Pages: 74-77

    • Related Report
      2017 Annual Research Report
  • [Journal Article] International, evidence-based consensus diagnostic criteria for HHV-8-negative/idiopathic multicentric Castleman disease.2017

    • Author(s)
      Fajgenbaum DC, Uldrick TS, Ide M, Yoshizaki K, van Rhee F, et al.
    • Journal Title

      Blood

      Volume: 129(12) Issue: 12 Pages: 1646-1657

    • DOI

      10.1182/blood-2016-10-746933

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A reference guide for management of Castleman disease2017

    • Author(s)
      吉崎和幸, 岡本真一郎,川端浩, 水木満佐央, 川上純, 正木康史, 矢野真吾, 井出眞, 宇野賀津子, 八木克巳, 小島俊行, 水谷実, 徳嶺進洋, 西本憲弘, 藤原寛, 中塚伸一, 塩沢和子, 岩城憲子, 古賀智裕
    • Journal Title

      Rinsho Ketsueki

      Volume: 58 Issue: 2 Pages: 97-107

    • DOI

      10.11406/rinketsu.58.97

    • NAID

      130005450490

    • ISSN
      0485-1439, 1882-0824
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mechanism and Clinical Significance of IL-6 Combined with TNF-α or IL-1 for the Induction of Acute Phase Proteins SAA and CRP in Chronic Inflammatory Diseases2016

    • Author(s)
      Soken-Nakazawa J Song and Kazuyuki Yoshizaki
    • Journal Title

      Journal of Alcoholism & Drug Dependence

      Volume: 4 Issue: 3 Pages: 1-4

    • DOI

      10.4172/2329-6488.1000239

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pretreatment Prediction of Individual Rheumatoid Arthritis Patients' Response to Anti-Cytokine Therapy Using Serum Cytokine/Chemokine/ Soluble Receptor Biomarkers.2015

    • Author(s)
      Uno K, Yoshizaki K, Iwahashi M, Yamana J, Yamana S, Tanigawa M, Yagi K.
    • Journal Title

      PLoS One

      Volume: Jul 15;10(7) Issue: 7 Pages: 1-15

    • DOI

      10.1371/journal.pone.0132055

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Changes in Serum Cytokines and Chemokines in Multicentric Castleman Disease after Tocilizumab IL-6 Blocking Therapy2017

    • Author(s)
      Kazuyuki Yoshizaki and Kazuko Uno
    • Organizer
      ICIS2017 The 5th Annual Meeting of the International Cytokine and Interferon Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 関節リウマチの治療前バイオマーカーによる個別化医療の開発2016

    • Author(s)
      吉崎和幸
    • Organizer
      日本臨床免疫学会ランチョンセミナー
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2016-09-08
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] The role of soluble forms of IL-6 receptor (sIL-6R) and soluble form of gp130 (sgp130) on the regulation of IL-6 signaling in rheumatoid arthritis.2016

    • Author(s)
      Kazuyuki Yoshizaki
    • Organizer
      ICI2016
    • Place of Presentation
      Melbourne (Australia)
    • Year and Date
      2016-08-21
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Soluble Form of GP130 Molecule, An IL-6 Inhibitor, Contributes The Efficacy on RA To Tocilizumab (An Anti-IL-6 Receptor Antibody) Therapy2016

    • Author(s)
      K. Yoshizaki, S. N. J. Song, H. Itoh, M. Iwahashi, K. Uno
    • Organizer
      EULAR 2016
    • Place of Presentation
      London (U.K.)
    • Year and Date
      2016-06-08
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Two soluble forms of IL-6 receptor, sIL-6R and sgp130, regulate physiological status and affect inflammatory status pathologically2015

    • Author(s)
      Kazuyuki Yoshizaki
    • Organizer
      FOCIS2015
    • Place of Presentation
      San Diego, California
    • Year and Date
      2015-06-24
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Funded Workshop] FOCIS20152015

    • Place of Presentation
      San Diego, California
    • Year and Date
      2015-06-24
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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