| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Self-reactive IgG autoantibodies are hallmark of autoimmune diseases, and often cause tissue damage. Although B1 cells, which naturally produce self-reactive IgM, are thought to be the precursor cells of IgG autoantibody-secreting cells in autoimmune diseases, the underlying mechanisms of differentiation process remain poorly understood. Here, we showed that activated B1 cells from autoimmune-prone mice migrated into germinal center of secondary lymphoid organ and then underwent a process of class switch recombination to IgG and differentiation into antibody-producing plasma cells. In addition, stimulation of TLR ligand and various cytokines in the germinal center like environment induced G5PR expression in B1 cells, leading to JNK suppression and plasma cell differentiation. These results suggest that regulation of G5PR/JNK pathway might be a potential therapeutic target for autoimmune diseases.
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