Establishment of treated with MSC for steroid resistant connective tissue disease
| Project/Area Number |
15K09539
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
藤盛 好啓 兵庫医科大学, 医学部, 教授 (20229058)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | MSC / mouse model / SLE / transfection / 全身性エリテマトーデス / 羊膜間葉系幹細胞 / SLEモデルマウス / ヒト羊膜ＭＳＣ / ＳＬＥモデル / ヒト羊膜間葉系幹細胞 / NZB/WF1 |
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| Outline of Final Research Achievements |
We studied with two strains (NZBWF1) and (MRL / lpr) which are systemic lupus erythematosus (SLE) model mice. The survival rates of NZBF1 or MRL / lpr mice (1 group: n = 10) of 24 weeks old were divided into three groups of control group, human amniotic membrane MSC transfection (0.5 × 106 / mouse), human amniotic membrane MSC transfection group (2 × 106 / mouse) We examined from the administration until 80 days. As with human amniotic membrane MSC transfection group (2 x 106 / mouse), there was suppression effect, but there was no significant difference in survival rate. In the future, we plan to investigate using a prestain-induced SLE model mouse. We plan to advance the examination by changing the animal model mouse and the examination on humans in parallel.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Assessment of 2012 EULAR/ACR New Classification Criteria for Polymyalgia Rheumatica in Japanese Patients Diagnosed using Bird's Criteria.2017
Author(s)
Matsui K, Maruoka M, Yoshikawa T, Hashimoto N, Nogami M, Sekiguchi M, Azuma N, Kitano M,、Tsunoda S and Sano H,
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Journal Title
Int. J. Rheum. Disease,
Volume: 6
Issue: 2
Pages: 497-501
DOI
Related Report
Peer Reviewed / Open Access
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