AIT efficacy regulated by the circadian clock in mice
| Project/Area Number |
15K09548
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Collagenous pathology/Allergology
|
|---|
| Research Institution | University of Yamanashi |
|---|
Principal Investigator |
NAKAMURA Yuki 山梨大学, 大学院総合研究部, 准教授 (90580465)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 花粉症 / 概日時計 / アレルギー / 免疫療法 |
|---|
| Outline of Final Research Achievements |
We have been showed that the circadian clock regulates symptoms of some allergic diseases exhibit prominent variations with a period of approximately 24 h [JACI 2011, 2014]. Based on these studies, this study performed whether the effect of time of day on AIT [Antigen specific Immunotherapy] efficacy with the goal of optimizing the therapeutic outcome in the mouse model of allergic rhinitis. In the AR model, mice sublingually receiving an antigen during resting phase exhibited a greater decrease in antigen-specific IgE levels than mice treated during waking phase or in a random manner. In addition, mice treated during resting phase exhibited reductions in antigen-specific cytokine production by splenocytes relative to mice treated during waking phase or in a random manner. These results suggested that the circadian clock regulates AIT to maximize its effectiveness.
|
Report
(4 results)
Research Products
(14 results)
-
-
-
-
-
[Journal Article] Inhibition of IgE-mediated allergic reactions by pharmacologically targeting the circadian clock.2015
Author(s)
Nakamura Y, Nakano N, Ishimaru K, Ando N, Katoh R, Suzuki-Inoue K, Koyanagki S, Ogawa H, Okumura K, Shibata S, Nakao A
-
Journal Title
The Journal of allergy and clinical immunology
Volume: 137(4)
Issue: 4
Pages: 1226-1235
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
