| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
We have been showed that the circadian clock regulates symptoms of some allergic diseases exhibit prominent variations with a period of approximately 24 h [JACI 2011, 2014]. Based on these studies, this study performed whether the effect of time of day on AIT [Antigen specific Immunotherapy] efficacy with the goal of optimizing the therapeutic outcome in the mouse model of allergic rhinitis. In the AR model, mice sublingually receiving an antigen during resting phase exhibited a greater decrease in antigen-specific IgE levels than mice treated during waking phase or in a random manner. In addition, mice treated during resting phase exhibited reductions in antigen-specific cytokine production by splenocytes relative to mice treated during waking phase or in a random manner. These results suggested that the circadian clock regulates AIT to maximize its effectiveness.
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