| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
To analyze the role of inflammatory dendritic cells and basophils as bronchial asthma onset and exacerbation factors, we performed following studies using induced sputum from asthmatic patients. 1) Establishment of induced sputum analysis by flow cytometry, 2) Analysis of inflammatory dendritic cells and basophils in induced sputum, 3) Phenotype identification of sputum basophils, 4) Relationship between sputum basophils and clinical phenotype in adult asthma.
The numbers of inflammatory dendritic cells and basophils in induced sputum were increased in adult asthmatic patients compared with those in normal controls. The number of sputum basophils was positively correlated with the number of sputum eosinophils. Furthermore, sputum basophils were activated compared with blood basophils from same patients. These observations suggest that basophils could be exacerbation factors of eosinophilic asthma.
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