Development of therapeutic foundation for allergic inflammation by elucidation of the periostin signaling pathway

• Project/Area Number: 15K09553
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Collagenous pathology/Allergology
• Research Institution: International University of Health and Welfare (2017-2018); Saga University (2015-2016)
• Principal Investigator: Ohta Shoichiro 国際医療福祉大学, 福岡保健医療学部, 教授 (20346886)
• Co-Investigator(Kenkyū-buntansha): 出原 賢治 佐賀大学, 医学部, 教授 (00270463) ; 小川 雅弘 佐賀大学, 医学部, 助教 (90599317)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ペリオスチン / マトリセルラータンパク質

Outline of Final Research Achievements

To elucidate the function of periostin, we attempted to identify and analyze periostin-binding proteins. As a result, we showed integrin αVβ3-expressing cells adhere the periostin-coated surface, indicating that integrin αVβ3 was one of periostin-binding proteins. Then we showed the periostin signaling in cell adhesion was mediated by NF-κB pathway. We also established anti-periositn antibodies that inhibited cell adhesion. On the other hand, we found that periostin inhibited cell adhesion in a certain condition, suggesting that periostin both facilitate and inhibit cell adhesion.

Academic Significance and Societal Importance of the Research Achievements

ペリオスチンは喘息やアトピー性皮膚炎といったアレルギー性炎症を含め、間質性肺炎や胆管細胞癌といった種々の炎症・線維化疾患でその発現が上昇する。われわれは、ペリオスチンがそれらの疾患の病態形成に関与すると同時に、病勢や予後を反映するバイオーマーカーの一つとなることを明らかにしてきた。本課題にてペリオスチンの結合分子と細胞内シグナル経路が明らかにされたことで、さらにそれら疾患の病態理解が進み、かつ、分子標的薬のコンパニオン診断薬として貢献できると考えられる。

Research Products

• [Int'l Joint Research] Karolinska Institutet/Uppsala University(スウェーデン)
• [Int'l Joint Research] University of Pittsburgh(米国)
• [Int'l Joint Research] インディアナ大学/コーネル大学/シンシナティ大学(米国)
• [Int'l Joint Research] サザンプトン大学(英国)
• [Int'l Joint Research] マヒドール大学(タイ)
• [Int'l Joint Research] マールブルク大学(ドイツ)
• [Int'l Joint Research] カロリンスカ研究所/ウプサラ大学(スウェーデン)
• [Int'l Joint Research]
• [Int'l Joint Research] インディアナ大学/コーネル大学/シンシナティ大学(米国)
• [Int'l Joint Research] サザンプトン大学(英国)
• [Int'l Joint Research] マヒドール大学(タイ)
• [Int'l Joint Research] マールブルク大学(ドイツ)
• [Int'l Joint Research] カロリンスカ研究所/ウプサラ大学(スウェーデン)
• [Int'l Joint Research]
• [Journal Article] Fixed airflow obstruction relates to eosinophil activation in asthmatics (2019)
  • Author(s): Ida Mogensen, Kjell Alving, Sven-Erik Dahlen, Anna James, Bertil Forsberg, Junya Ono, Shoichiro Ohta, Per Venge, Magnus P. Borres, Kenji Izuhara, Christer Janson, and Andrei Malinovschi
  • Journal Title: Clinical & Experimental Allergy Volume: 49 Issue: 2 Pages: 155-163
  • DOI: 10.1111/cea.13302
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Elevated Periostin Concentrations in the Bronchoalveolar Lavage Fluid of Patients with Eosinophilic Pneumonia. (2019)
  • Author(s): Nakagome K, Nakamura Y, Kobayashi T, Ohta S, Ono J, Kobayashi K, Ikebuchi K, Noguchi T, Soma T, Yamauchi K, Izuhara K, Nagata M.
  • Journal Title: Int Arch Allergy Immunol. Volume: 178 Issue: 3 Pages: 264-271
  • DOI: 10.1159/000494623
  • Peer Reviewed
• [Journal Article] Impaired antigen‐specific lymphocyte priming in mice after Toll‐like receptor 4 activation via induction of monocytic myeloid‐derived suppressor cells (2019)
  • Author(s): Tsukamoto Hiroki、Kozakai Sao、Kobayashi Yohei、Takanashi Risako、Aoyagi Takuya、Numasaki Muneo、Ohta Shoichiro、Tomioka Yoshihisa
  • Journal Title: European Journal of Immunology Volume: 49 Issue: 4 Pages: 546-563
  • DOI: 10.1002/eji.201847805
  • Peer Reviewed
• [Journal Article] Periostin as a predictor of prognosis in chronic bird-related hypersensitivity pneumonitis (2019)
  • Author(s): Nukui Yoshihisa、Miyazaki Yasunari、Masuo Masahiro、Okamoto Tsukasa、Furusawa Haruhiko、Tateishi Tomoya、Kishino Mitsuhiro、Tateishi Ukihide、Ono Junya、Ohta Shoichiro、Izuhara Kenji、Inase Naohiko
  • Journal Title: Allergology International Volume: 68 Issue: 3 Pages: 363-369
  • DOI: 10.1016/j.alit.2019.02.007
  • NAID: 130007678459
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed
• [Journal Article] Serum levels of squamous cell carcinoma antigens 1 and 2 reflect disease severity and clinical type of atopic dermatitis in adult patients (2018)
  • Author(s): Tomoko Okawa, Yukie Yamaguchi, et al.
  • Journal Title: Allergology International Volume: 67 Issue: 1 Pages: 124-130
  • DOI: 10.1016/j.alit.2017.06.016
  • NAID: 130006322096
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] Up-regulation of serum periostin and squamous cell carcinoma antigen levels in infants with acute bronchitis due to respiratory syncytial virus (2018)
  • Author(s): Hiroaki Nakamura, Kenichi Akashi, et al.
  • Journal Title: Allergology International Volume: 67 Issue: 2 Pages: 259-265
  • DOI: 10.1016/j.alit.2017.10.003
  • NAID: 130006721831
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] SCCA2 is a reliable biomarker for evaluating pediatric atopic dermatitis (2018)
  • Author(s): Nagao Mizuho、Inagaki Shinichiro、Kawano Toshiki、Azuma Yoshinori、Nomura Noriko、Noguchi Yasuhiko、Ohta Shoichiro、Kawaguchi Atsushi、Odajima Hiroshi、Ohya Yukihiro、Fujisawa Takao、Izuhara Kenji
  • Journal Title: Journal of Allergy and Clinical Immunology Volume: 141 Issue: 5 Pages: 1934-1936
  • DOI: 10.1016/j.jaci.2018.01.021
  • Peer Reviewed / Open Access
• [Journal Article] Squamous Cell Carcinoma Antigen 2 (SCCA2, SERPINB4): An Emerging Biomarker for Skin Inflammatory Diseases (2018)
  • Author(s): Izuhara Kenji、Yamaguchi Yukie、Ohta Shoichiro、Nunomura Satoshi、Nanri Yasuhiro、Azuma Yoshinori、Nomura Noriko、Noguchi Yasuhiko、Aihara Michiko
  • Journal Title: International Journal of Molecular Sciences Volume: 19 Issue: 4 Pages: 1102-1102
  • DOI: 10.3390/ijms19041102
  • Peer Reviewed / Open Access
• [Journal Article] Serum periostin levels serve as a biomarker for both eosinophilic airway inflammation and fixed airflow limitation in well-controlled asthmatics (2018)
  • Author(s): Kentaro Takahashi, Kazuyuki Meguro, Hirotoshi Kawashima, Daisuke Kashiwakuma, Shin-ichiro Kagami, Shoichiro Ohta, Junya Ono, Kenji Izuhara and Itsuo Iwamoto
  • Journal Title: Journal of Asthma Volume: 56 Issue: 3 Pages: 236-243
  • DOI: 10.1080/02770903.2018.1455855
  • Peer Reviewed
• [Journal Article] IgE sensitization to food allergens and airborne allergens in relation to biomarkers of type 2 inflammation in asthma (2018)
  • Author(s): Patelis A.、Alving K.、Middelveld R.、James A.、Ono J.、Ohta S.、Izuhara K.、Borres M. P.、Forsberg B.、Janson C.、Malinovschi A.
  • Journal Title: Clinical & Experimental Allergy Volume: 48 Issue: 9 Pages: 1147-1154
  • DOI: 10.1111/cea.13165
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prospective predictors of exacerbation status in severe asthma over a 3-year follow-up (2018)
  • Author(s): Kimura H.、Konno S.、Makita H.、Taniguchi N.、Shimizu K.、Suzuki M.、Kimura H.、Goudarzi H.、Nakamaru Y.、Ono J.、Ohta S.、Izuhara K.、Ito Y.?M.、Wenzel S. E.、Nishimura M.、for the Hi-CARAT investigators
  • Journal Title: Clinical & Experimental Allergy Volume: 48 Issue: 9 Pages: 1137-1146
  • DOI: 10.1111/cea.13170
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Periostin as a novel biomarker for postoperative recurrence of chronic rhinosinitis with nasal polyps. (2018)
  • Author(s): Ninomiya T, Noguchi E, Haruna T, Hasegawa M, Yoshida T, Yamashita Y, Okano M, Yoshida N, Haruna S, Sakuma Y, Ohta S, Ono J, Izuhara K, Okada M, Kidoguchi M, Tokunaga T, Okamoto M, Kanno M, Sakashita M, Takabayashi T, Narita N, Fujieda S.
  • Journal Title: Sci Rep. Volume: 8(1) Issue: 1 Pages: 11450-11450
  • DOI: 10.1038/s41598-018-29612-2
  • NAID: 120007133851
  • Peer Reviewed / Open Access
• [Journal Article] The usefulness of monomeric periostin as a biomarker for idiopathic pulmonary fibrosis (2017)
  • Author(s): Ohta S, Okamoto M, Fujimoto K, Sakamoto N, Takahashi K, Yamamoto H, Kushima H, Ishii H, Akasaka K, Ono J, Kamei A, Azuma Y, Matsumoto H, Yamaguchi Y, Aihara M, Johkoh T, Kawaguchi A, Ichiki M, Sagara H, Kadota JI, Hanaoka M, Hayashi SI, Kohno S, Hoshino T, Izuhara K
  • Journal Title: PloS one Volume: 12 Issue: 3 Pages: e0174547-e0174547
  • DOI: 10.1371/journal.pone.0174547
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] IL4Rα and ADAM33 as genetic markers in asthma exacerbations and type-2 inflammatory endotype (2017)
  • Author(s): Sunadome H.、Matsumoto H.、et al.
  • Journal Title: Clinical & Experimental Allergy Volume: 47 Issue: 8 Pages: 998-1006
  • DOI: 10.1111/cea.12927
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Therapeutic Effect of Novel Single-Stranded RNAi Agent Targeting Periostin in Eyes with Retinal Neovascularization. (2017)
  • Author(s): Nakama T, Yoshida S
  • Journal Title: Mol Ther Nucleic Acids. Volume: 17 Pages: 279-289
  • DOI: 10.1016/j.omtn.2017.01.004
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Staphylococcus aureus enterotoxin sensitization involvement and its association with the CysLTR1 variant in different asthma phenotypes. (2017)
  • Author(s): Matsumoto H, Kanemitsu Y, Nagasaki T, (26 authors), Tabara Y, Matsuda F, Izuhara K, Niimi A, Mishima M.
  • Journal Title: Ann Allergy Asthma Immunol. Volume: 118 Issue: 2 Pages: 197-203
  • DOI: 10.1016/j.anai.2016.11.013
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Clarithromycin attenuates IL-13-induced periostin production in human lung fibroblasts (2017)
  • Author(s): Kosaku Komiya, Shoichiro Ohta, Kazuhiko Arima, Masahiro Ogawa, Shoichi Suzuki, Yasutaka Mitamura, Yasuhiro Nanri, Tomohito Yoshihara, Atsushi Kawaguchi, Junichi Kadota, Bruce K. Rubin, and Kenji Izuhara
  • Journal Title: Respiratory Research Volume: 18 Issue: 1 Pages: 37-37
  • DOI: 10.1186/s12931-017-0519-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Serum periostin relates to type-2 inflammation and lung function in asthma: Data from the large population-based cohort Swedish GA(2)LEN (2017)
  • Author(s): James A.、Janson C.、Malinovschi A.、Holweg C.、Alving K.、Ono J.、Ohta S.、Ek A.、Middelveld R.、Dahl?n B.、Forsberg B.、Izuhara K.、Dahl?n S.-E.
  • Journal Title: Allergy Volume: 72 Issue: 11 Pages: 1753-1760
  • DOI: 10.1111/all.13181
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Clustering of patients with intrahepatic cholangiocarcinoma based on serum periostin may be predictive of prognosis (2017)
  • Author(s): Thuwajit Chanitra、Thuwajit Peti、Jamjantra Pranisa、Pairojkul Chawalit、Wongkham Sopit、Bhudhisawasdi Vajarabhongsa、Ono Junya、Ohta Shoichiro、Fujimoto Kiminori、Izuhara Kenji
  • Journal Title: Oncology Letters Volume: 14 Issue: 1 Pages: 623-634
  • DOI: 10.3892/ol.2017.6250
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Serum periostin as a useful biomarker of comorbid chronic rhinosinusitis in patients with asthma (2017)
  • Author(s): Takamitsu Asano, Yoshihiro Kanemitsu, Masaya Takemura, Makoto Yokota, Kensuk Fukumitsu e, Norihisa Takeda, Hiroya Ichikawa, Takehiro Uemura, Osamu Takakuwa, Hirotsugu Ohkubo, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Yumi Maki, Junya Ono, Shoichiro Ohta, Yoshihisa Nakamura, Kenji Izuhara, Motohiko Suzuki, and Akio Niimi
  • Journal Title: Annals of the American Thoracic Society Volume: 印刷中 Issue: 5 Pages: 667-675
  • DOI: 10.1513/annalsats.201609-720oc
  • Peer Reviewed / Open Access
• [Journal Article] Sinus Computed Tomographic Findings in Adult Smokers and Nonsmokers with Asthma. Analysis of Clinical Indices and Biomarkers. (2017)
  • Author(s): Kimura H, et al
  • Journal Title: Ann Am Thorac Soc Volume: 14 Issue: 3 Pages: 332-341
  • DOI: 10.1513/annalsats.201606-463oc
  • Peer Reviewed / Open Access
• [Journal Article] Circulating activated innate lymphoid cells and mucosal-associated invariant T cells are associated with airflow limitation in patients with asthma (2017)
  • Author(s): Ishimori A, Harada N, Chiba A, Harada S, Matsuno K, Makino F, Ito J, Ohta S, Ono Junya, Atsuta R, Izuhara K, Takahashi K, Miyake S
  • Journal Title: Allergology International Volume: 66 Issue: 2 Pages: 302-309
  • DOI: 10.1016/j.alit.2016.07.005
  • NAID: 130005628231
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] Serum Biomarkers for the Diagnosis of Eosinophilic Esophagitis and Eosinophilic Gastroenteritis (2017)
  • Author(s): Shunji Ishihara, Tetsuo Shoda, et al.
  • Journal Title: Internal Medicine Volume: 56 Issue: 21 Pages: 2819-2825
  • DOI: 10.2169/internalmedicine.8763-16
  • NAID: 130006191952
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] Clustering of intrahepatic cholangiocarcinoma patients based on serum periostin can predict its prognosis (2017)
  • Author(s): Chanitra Thuwajit, Peti Thuwajit, Pranisa Jamjantra, Chawalit Pairojkul, Sopit Wongkham, Vajarabhongsa Bhudhisawasdi, Junya Ono, Shoichiro Ohta, Kiminori Fujimoto, and Kenji Izuhara
  • Journal Title: Oncology Letters Volume: 印刷中
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Serum biomarkers for diagnosis of eosinophilic esophagitis and eosinophilic gastroenteritis (2017)
  • Author(s): Shunji Ishihara, Tetsuo Shoda, Norihisa Ishimura, Shoichiro Ohta, Junya Ono, Yoshinori Azuma, Eiko Okimoto, Kenji Izuhara, Ichiro Nomura, Kenji Matsumoto, and ikazu Kinoshita
  • Journal Title: Internal Medicine Volume: 印刷中
  • NAID: 130006191952
  • Peer Reviewed
• [Journal Article] Increased YKL-40 and chitotriosidase in asthma and chronic obstructive pulmonary disease (2016)
  • Author(s): James AJ, Reinius LE, Verhoek M, Gomes A, Kupczyk M, Hammar U, Ono J, Ohta S, Izuhara K, Bel E, Kere J, Söderhäll C, Dahlén B, Boot RG, Dahlén S
  • Journal Title: American Journal of Respiratory and Critical Care Medicine Volume: 193 Issue: 2 Pages: 131-142
  • DOI: 10.1164/rccm.201504-0760oc
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Multidimensional endotyping in severe asthma reveals inflammatory heterogeneity in MMPs and YKL-40 (2016)
  • Author(s): Hinks T, Brown T, Lau LCK, Rupani H, Barber C, Elliott S, Ward JA, Ono J, Ohta S, Izuhara K, Djukanovi; R, Kurukulaaratchy R, Chauhan A, Howarth PH
  • Journal Title: Journal of Allergy and Clinical Immunology Volume: 138 Issue: 1 Pages: 61-75
  • DOI: 10.1016/j.jaci.2015.11.020
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The usefulness of measuring tear periostin for the diagnosis and management of ocular allergic diseases. (2016)
  • Author(s): Fujishima H, Okada N, Matsumoto K, Fukagawa K, Igarashi A, Matsuda A, Ono J, Ohta S, Mukai H, Yoshikawa M, Izuhara K.
  • Journal Title: J Allergy Clin Immunol Volume: Epub ahead of print Issue: 2 Pages: 0-0
  • DOI: 10.1016/j.jaci.2015.11.039
  • NAID: 40020962730
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Clinical implication of the serum periostin level for differentiating phenotypes of NSAID hypersensitivity (2016)
  • Author(s): Kim M, Yoon MK, Lee Y-S, Izuhara K, Ohta S, Ono J, Kim J-H, Ban GY, Ye Y-M, Park H-S
  • Journal Title: Allergology International Volume: 65 Issue: 4 Pages: 492-494
  • DOI: 10.1016/j.alit.2016.04.013
  • NAID: 130005431272
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Periostin and Interleukin-13 Are Independently Related to Chronic Spontaneous Urticaria (2016)
  • Author(s): Bae Y, Izuhara K, Ohta S, Ono J, Hong GU, Ro JY, Park GH, Choi JH
  • Journal Title: Allergy, Asthma & Immunology Research Volume: 8 Issue: 5 Pages: 457-460
  • DOI: 10.4168/aair.2016.8.5.457
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Using periostin as a biomarker in the treatment of asthma (2016)
  • Author(s): Izuhara K, Ohta S, Ono S
  • Journal Title: Allergy, Asthma and Immunology Research Volume: 8 Issue: 6 Pages: 491-498
  • DOI: 10.4168/aair.2016.8.6.491
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Periostin promotes hepatic fibrosis in mice by modulating hepatic stellate cell activation via αv integrin interaction. (2016)
  • Author(s): Sugiyama A, Kanno K, Nishimichi N, Yokosaki Y, Izuhara K, Ono J, Tazuma S.
  • Journal Title: J Gastroenteroln Volume: in press Issue: 12 Pages: 1161-1174
  • DOI: 10.1007/s00535-016-1206-0
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Utility of serum periostin and free IgE levels in evaluating responsiveness to omalizumab in patients with severe asthma. (2016)
  • Author(s): Tajiri T, Matsumoto H, Gon Y, Ito R, Hashimoto S, Izuhara K, Suzukawa M, Ohta K, Ono J, Ohta S, Ito I, Oguma T, Inoue H, Iwata T, Kanemitsu Y, Nagasaki T, Niimi A, Mishima M.
  • Journal Title: Allergy Volume: 未定 Issue: 10 Pages: 1472-1479
  • DOI: 10.1111/all.12922
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Periostin as a biomarker for diagnosis of pediatric asthma (2016)
  • Author(s): Inoue T, Akashi K, Watanabe M, Ikeda Y, Ashizuka S, Motoki T, Suzuki R, Sagara N, Yanagida N, Sato S, Ebisawa M, Ohta S, Ono J, Izuhara K, Katunuma T
  • Journal Title: Pediatric Allergy and Immunology Volume: 27 Issue: 5 Pages: 521-526
  • DOI: 10.1111/pai.12575
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The potential for repositioning antithyroid agents as antiasthma drugs. (2016)
  • Author(s): Suzuki S, Ogawa M, Ohta S, Arima K, Nunomura S, Nanri Y, Mitamura Y, Yoshihara T, Nakamura Y, Yamauchi K, Chibana K, Ishii Y, Lee JJ, Aratani Y, Kakuta S, Kubo S, Iwakura Y, Yoshida H, Izuhara K.
  • Journal Title: J Allergy Clin Immunol. Volume: 138 Issue: 5 Pages: 1458-1461
  • DOI: 10.1016/j.jaci.2016.04.047
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Induction of airway allergic inflammation by hypothiocyanite via epithelial cells (2016)
  • Author(s): Suzuki S, Ogawa M, Ohta S, Nunomura S, Nanri Y, Shiraishi H, Mitamura Y, Yoshihara T, James J. Lee, Izuhara K
  • Journal Title: Journal of Biological Chemistry Volume: 291 Issue: 53 Pages: 27219-27227
  • DOI: 10.1074/jbc.m116.746909
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Periostin contributes to epidermal hyperplasia in psoriasis common to atopic dermatitis (2015)
  • Author(s): Arima K, Ohta S, Takagi A, Shiraishi H, Masuoka M, Ontsuka K, Suto H, Suzuki S, Yamamoto K-i, Ogawa M, Simmons O, Yamaguchi Y, Toda S, Aihara M, Conway SJ, Ikeda S, Izuhara K.
  • Journal Title: Allergology International Volume: 64 Issue: 1 Pages: 41-48
  • DOI: 10.1016/j.alit.2014.06.001
  • NAID: 130004873124
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Reversal of New-Onset Type 1 Diabetes With an Agonistic TLR4/MD-2 Monoclonal Antibody (2015)
  • Author(s): Bednar, K.J., Tsukamoto, H., Kachapati, K., Ohta, S., Wu, Y., Katz, J.D., Ascherman, D.P. & Ridgway, W.M.
  • Journal Title: Diabetes Volume: 64 Issue: 10 Pages: 3614-3626
  • DOI: 10.2337/db14-1868
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Induction of Interleukin-9-Producing Mucosal Mast Cells Promotes Susceptibility to IgE-Mediated Experimental Food Allergy (2015)
  • Author(s): Chen, C.Y., Lee, J.B., Liu, B., Ohta, S., Wang, P.Y., Kartashov, A.V., Mugge, L., Abonia, J.P., Barski, A., Izuhara, K., Rothenberg, M.E., Finkelman, F.D., Hogan, S.P. & Wang, Y.H.
  • Journal Title: Immunity Volume: 43 Issue: 4 Pages: 788-802
  • DOI: 10.1016/j.immuni.2015.08.020
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Periostin Is a Key Niche Component for Wound Metastasis of Melanoma. (2015)
  • Author(s): Fukuda K, Sugihara E, Ohta S, Izuhara K, Funakoshi T, Amagai M, Saya H.
  • Journal Title: PLoS One Volume: 10 Issue: 6 Pages: e0129704-e0129704
  • DOI: 10.1371/journal.pone.0129704
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] No increase in the serum periostin level is detected in elementary school-age children with allergic diseases (2015)
  • Author(s): Inoue, Y., Izuhara, K., Ohta, S., Ono, J. & Shimojo, N.
  • Journal Title: Allergology International Volume: 64 Issue: 3 Pages: 289-290
  • DOI: 10.1016/j.alit.2015.04.001
  • NAID: 130005290276
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Predicting asthma morbidity in children using proposed markers of Th2-type inflammation (2015)
  • Author(s): Konradsen, J.R., Skantz, E., Nordlund, B., Lidegran, M., James, A., Ono, J., Ohta, S., Izuhara, K., Dahlen, S.E., Alving, K. & Hedlin, G.
  • Journal Title: Pediatric allergy and immunology Volume: 26 Issue: 8 Pages: 772-9
  • DOI: 10.1111/pai.12457
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Phenotype of asthma related with high serum periostin levels (2015)
  • Author(s): Matsusaka M, Kabata H, Fukunaga K, Suzuki Y, Masaki K, Mochimaru T, Sakamaki F, Oyamada Y, Inoue T, Oguma T, Sayama K, Koh H, Nakamura M, Umeda A, Ono J, Ohta S, Izuhara K, Asano K, Betsuyaku T.
  • Journal Title: Allergology International Volume: 64 Issue: 2 Pages: 175-180
  • DOI: 10.1016/j.alit.2014.07.003
  • NAID: 130005290305
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] Periostin in the bronchial lavage fluid of asthma patients (2015)
  • Author(s): akamura, Y., Nagashima, H., Ohta, S., Ono, J., Yamauchi, K. & Izuhara, K.
  • Journal Title: Allergology International Volume: 64 Issue: 2 Pages: 209-210
  • DOI: 10.1016/j.alit.2015.01.001
  • NAID: 130005290284
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Serum level of periostin can predict long-term outcome of idiopathic pulmonary fibrosis (2015)
  • Author(s): Tajiri, M., Okamoto, M., Fujimoto, K., Johkoh, T., Ono, J., Tominaga, M., Azuma, K., Kawayama, T., Ohta, S., Izuhara, K. & Hoshino, T.
  • Journal Title: Respiratory investigation Volume: 53 Issue: 2 Pages: 73-81
  • DOI: 10.1016/j.resinv.2014.12.003
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 気管支喘息とペリオスチン (2015)
  • Author(s): 太田昭一郎，出原賢治
  • Journal Title: 分子呼吸器病 Volume: 19 Pages: 20-23
  • Acknowledgement Compliant
• [Journal Article] 重傷喘息患者治療におけるバイオマーカー（ペリオスチン） (2015)
  • Author(s): 太田昭一郎，出原賢治
  • Journal Title: Respiratory Trends Volume: 5 Pages: 12-15
  • Acknowledgement Compliant
• [Journal Article] ペリオスチン：特発性肺線維症の新規診断薬 (2015)
  • Author(s): 太田昭一郎，出原賢治
  • Journal Title: 臨床化学 Volume: 44 Pages: 30-36
  • Acknowledgement Compliant
• [Journal Article] 呼吸器疾患マーカーとしてのペリオスチン (2015)
  • Author(s): 太田昭一郎，出原賢治
  • Journal Title: Medical Technology Volume: 43 Pages: 688-690
  • Acknowledgement Compliant
• [Presentation] Xolair導入後の血清IgEなどの推移 (2018)
  • Author(s): 森本千絵、松本久子、田尻智子、鈴川真穂、出原裕美、権寧博、伊藤玲子、橋本修、出原賢治、太田昭一郎、小野純也、大田健、金光禎寛、長崎忠雄、小熊毅、伊藤功朗、新実彰男、平井豊博
  • Organizer: 第67回日本アレルギー学会学術大会
• [Presentation] Omalizumab投与後も増悪が残る重症例の検討 (2018)
  • Author(s): 森本千絵、松本久子、田尻智子、鈴川真穂、出原裕美、権寧博、伊藤玲子、橋本修、出原賢治、太田昭一郎、小野純也、大田健、金光禎寛、長崎忠雄、小熊毅、伊藤功朗、新実彰男、平井豊博
  • Organizer: 第17回Kinki Hokuriku Airway disease Conference
• [Presentation] 小児アトピー性皮膚炎のバイオマーカーとしてのSCCA2の有用性 (2018)
  • Author(s): 野村紀子、東義則、稲垣真一郎、長尾みづほ、川野聖明、太田昭一郎、川口淳、野口保彦、小田嶋博、大矢幸弘、藤澤 隆夫、出原賢治
  • Organizer: 第51回日本臨床化学会年次学術集会
• [Presentation] 子宮体癌幹細胞を選択的に分取するための有用なマーカー探索 (2018)
  • Author(s): 四丸知弥、富安聡、澁田樹、高田勇吉、佐藤謙一、志村華絵、太田昭一郎、梅村創、大田喜孝、佐藤信也
  • Organizer: 第65回日本臨床検査医学会学術集会
• [Presentation] B細胞の接着を誘導する新規細胞表面分子の同定 (2018)
  • Author(s): 太田昭一郎、森山良太
  • Organizer: 第8回国際医療福祉大学学術大会
• [Presentation] Serum biomarkers for diagnosis of eosinophilic esophagitis and eosinophilic gastroenteritis (2017)
  • Author(s): Shunji Ishihara1, Naoki Oshima1, Tetsuo Shoda, Norihisa Ishimur1, Shoichiro Ohta, Junya Ono, Yoshinori Azuma, Eiko Okimoto, Kenji Izuhara, Ichiro Nomura, Kenji Matsumoto, and Yoshikazu Kinoshita
  • Organizer: 5th Biennial Congress of the Asian Neurogastroenterology & Motility Association
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2017-03-23
  • Int'l Joint Research
• [Presentation] Risks for asthma exacerbations in patients with type 2-low endotype. (2017)
  • Author(s): Yumi Ishiyama, Hisako Matsumoto, et al.
  • Organizer: European Respiratory Society International Congress 2017
  • Int'l Joint Research
• [Presentation] Serum biomarkers for the diagnosis of eosinophilic esophagitis and eosinophilic gastroenteritis. (2017)
  • Author(s): Shunji Ishihara, Naoki Oshima, et al.
  • Organizer: 5th Biennial Congress of the Asian Neurogastroenterology & Motility Association
  • Int'l Joint Research
• [Presentation] Serum periostin as a valuable biomarker of comorbid chronic rhinosinusitis in patients with asthma (2016)
  • Author(s): Takamitsu Asano, Yoshihiro Kanemitsu, Masaya Takemura, Makoto Yokota, Kensuke Fukumitsu, Norihisa Takeda, Hiroya Ichikawa, Shoichiro Ohta, Yoshihisa Nakamura, Kenji Izuhara, Motohiko Suzuki, Akio Niimi
  • Organizer: European Respiratory Society International Congress 2016
  • Place of Presentation: London, UK
  • Year and Date: 2016-09-03
  • Int'l Joint Research
• [Presentation] Dupilumab reduces severe exacerbations in periostin-high and periostin-low asthma patients (2016)
  • Author(s): Sally Wenzel, Brian Swanson, Ariel Teper, Jennifer Hamilton, Kenji Izuhara, Shoichiro Ohta, Junya Ono, Hongjie Zhu, Bingzhi Zhang, Heribert Staudinger, Neil M.H. Graham, Gianluca Pirozzi
  • Organizer: European Respiratory Society International Congress 2016
  • Place of Presentation: London, UK
  • Year and Date: 2016-09-03
  • Int'l Joint Research
• [Presentation] A novel, automated periostin assay; correlation with a commercial ELISA method and usability as an asthma biomarker (2016)
  • Author(s): Masayuki Takai, Junya Ono, Ayami Kamei, Hisako Matsumoto, Shoichiro Ohta, Kenji Izuhara
  • Organizer: European Respiratory Society International Congress 2016
  • Place of Presentation: London, UK
  • Year and Date: 2016-09-03
  • Int'l Joint Research
• [Presentation] Simultaneously increased serum periostin and urinary EDN relates to reduced lung function in adults with asthma from the Swedish GA2LEN study (2016)
  • Author(s): Andrei Malinovschi, Christer Janson, Anna James, Ida Mogensen, Bertil Forsberg, Junya Ono, Shoichiro Ohta, Kjell Alving, Kenji Izuhara, Sven-Erik Dahlen
  • Organizer: European Respiratory Society International Congress 2016
  • Place of Presentation: London, UK
  • Year and Date: 2016-09-03
  • Int'l Joint Research
• [Presentation] Free serum IL-18 levels and responsiveness to omalizumab in patients with severe asthma (2016)
  • Author(s): Tomoko Tajiri, Hisako Matsumoto, Yasuhiro Gon, Reiko Ito, Shu Hashimoto, Kenji Izuhara, Junya Ono, Shoichiro Ohta, Isao Ito, Tsuyoshi Oguma, Hideki Inoue, Toshiyuki Iwata, Tadao Nagasaki, Yoshihiro Kanemitsu, Akio Niimi, Michiaki Mishima
  • Organizer: European Respiratory Society International Congress 2016
  • Place of Presentation: London, UK
  • Year and Date: 2016-09-03
  • Int'l Joint Research
• [Presentation] Polymorphisms of IL4RA and ADAM33, Risk Variants in Patients with Asthma Exacerbations with Type 2-Predominant Condition (2016)
  • Author(s): Hironobu Sunadome, Hisako Matsumoto et al.
  • Organizer: 2016 American Thoracic Society International Conference
  • Place of Presentation: San Francisco, CA, USA
  • Year and Date: 2016-05-13
  • Int'l Joint Research
• [Presentation] Utility of Serum Periostin and Free IgE Levels in Evaluating Responsiveness to Omalizumab in Patients with Severe Asthma (2016)
  • Author(s): T. Tajiri, H. Matsumoto, Y. Gon, R. Ito, S. Hashimoto, K. Izuhara, M. Suzukawa, K. Ohta, J. Ono, S. Ohta, I. Ito, T. Oguma, H. Inoue, T. Iwata, T. Nagasaki, Y. Kanemitsu, A. Niimi, and M. Mishima
  • Organizer: 2016 American Thoracic Society International Conference
  • Place of Presentation: San Francisco, CA, USA
  • Year and Date: 2016-05-13
  • Int'l Joint Research
• [Presentation] The potential for repositioning anti-thyroid agents as anti-asthma drugs (2016)
  • Author(s): Kenji Izuhara, Shoichiro Ohta, Masaki Okamoto, Noriho Sakamoto, Koichiro Takahashi, Hiroshi Yamamoto, Hisako Kushima, Keiichi Akasaka, Kiminori Fujimoto, and Junya Ono
  • Organizer: 31st Symposium of the Collegium Internationale Allergologicum
  • Place of Presentation: Charleston, SC, USA
  • Year and Date: 2016-04-03
  • Int'l Joint Research
• [Presentation] Comprehensive evaluation of serum periostin as a phenotype-specific biomarker in asthma (2016)
  • Author(s): Anna James, Andrei Malinovschi, Maciek Kupczyk, Junya Ono, Shoichiro Ohta, Kenji Izuhara, Jon Konradsen, Barbro Dahén, Gunilla Hedlin, Christer Jansson on behalf of the GALEN consortium, Sven-Erik Dahlén on behalf of the BIOAIR consortium
  • Organizer: 31st Symposium of the Collegium Internationale Allergologicum
  • Place of Presentation: Charleston, SC, USA
  • Year and Date: 2016-04-03
  • Int'l Joint Research
• [Presentation] Activation of peroxidases causes airway inflammation via production of hypothiocyanite (2016)
  • Author(s): Masahiro Ogawa, Shoichi Suzuki, Shoichiro Ohta, Masutaka Furue, and Kenji Izuhara
  • Organizer: 31st Symposium of the Collegium Internationale Allergologicum
  • Place of Presentation: Charleston, SC, USA
  • Year and Date: 2016-04-03
  • Int'l Joint Research
• [Presentation] Analysis of transcriptional regulation for periostin (2016)
  • Author(s): Yasutaka Mitamura, Yasuhiro Nanri, Masahiro Ogawa, Shoichiro Ohta, and Kenji Izuhara
  • Organizer: 31st Symposium of the Collegium Internationale Allergologicum
  • Place of Presentation: Charleston, SC, USA
  • Year and Date: 2016-04-03
  • Int'l Joint Research
• [Presentation] No increase in the serum periostin level is detected in elementary school-age children with allergic diseases (2015)
  • Author(s): Yuzaburo Inoue, Kenji Izuhara, Shoichiro Ohta, Junya Ono, and Naoki Shimojo
  • Organizer: XXIV World Allergy Congress
  • Place of Presentation: Soul, Korea
  • Year and Date: 2015-10-14
  • Int'l Joint Research
• [Presentation] Up-regulation of serum periostin and squamous cell carcinoma antigen levels in respiratory syncytial virus bronchitis of infants (2015)
  • Author(s): Hiroaki Nakamura, Kenichi Akashi, Masako Watanabe, Shoichiro Ohta, Junya Ono, Yoshinori Azuma, Takashi Sekine, Kenji Izuhara, and Toshio Katsunuma
  • Organizer: European Respiratory Society International Congress 2015
  • Place of Presentation: Amsterdam, Netherland
  • Year and Date: 2015-09-26
  • Int'l Joint Research
• [Presentation] Usefulness of periostin as a biomarker of pediatric asthma (2015)
  • Author(s): Takashi Inoue, Kenichi Akashi, Suzuki Ryohei, Masako Watanabe, Kenji Izuhara, Shoichito Ohta, Junya Ono, Noriyuki Yanagida, Sakura Sato, Motohiro Ebisawa, Shuuichi Ashizuka, and Toshio Katsunuma
  • Organizer: European Respiratory Society International Congress 2015
  • Place of Presentation: Amsterdam, Netherland
  • Year and Date: 2015-09-26
  • Int'l Joint Research
• [Presentation] sefulness of periostin as a biomarker of pediatric asthma (2015)
  • Author(s): Kenji Izuhara, Shoichiro Ohta, Masaki Okamoto, Noriho Sakamoto, Koichiro Takahashi, Hiroshi Yamamoto, Hisako Kushima, Keiichi Akasaka, Kiminori Fujimoto, Junya Ono
  • Organizer: European Respiratory Society International Congress 2015
  • Place of Presentation: Amsterdam, Netherland
  • Year and Date: 2015-09-26
  • Int'l Joint Research
• [Presentation] Up-regulation of periostin production in tears of allergic ocular disease patients (2015)
  • Author(s): Naoko Okada, Hiroshi Fujishima, Kazumi Fukagawa, Kenji Izuhara, Shoichiro Ohta, Junya Ono, Akio Matsuda, Hirohisa Saito and Kenji Matsumoto
  • Organizer: uropean Academy of Allergy and Clinical Immunology Congress 2015
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2015-06-06
  • Int'l Joint Research
• [Presentation] A multicenter evaluation of a new periostin detection kit for idiopathic pulmonary fibrosis (2015)
  • Author(s): Kenji Izuhara, Shoichiro Ohta, Masaki Okamoto, Noriho Sakamoto, Koichiro Takahashi, Hiroshi Yamamoto, Hisako Kushima, Keiichi Akasaka, Kiminori Fujimoto, and Junya Ono
  • Organizer: 2015 American Thoracic Society International Conference
  • Place of Presentation: Denver, CO
  • Year and Date: 2015-05-15
  • Int'l Joint Research
• [Presentation] Using exhaled nitric oxide and serum periostin as a composite marker to identify severe/steroid-insensitive asthma (2015)
  • Author(s): Tadao Nagasaki, Hisako Matsumoto, Yoshihiro Kanemitsu, Kenji Izuhara, Yuji Tohda, Takahiko Horiguchi, Hideo Kita, Keisuke Tomii, Masaki Fujimura, Akihito Yokoyama, Yasutaka Nakano, Soichiro Hozawa, Isao Ito, Tsuyoshi Oguma, Yumi Izuhara, Tomoko Tajiri, Toshiyuki Iwata, Junya Ono, Shoichiro Ohta et al
  • Organizer: 015 American Thoracic Society International Conference
  • Place of Presentation: Denver, CO
  • Year and Date: 2015-05-15
  • Int'l Joint Research
• [Book] Evolution of Atopic Dermatitis in the 21st Century (2018)
  • Author(s): Kenji Izuhara, Satoshi Nunomura, Shoichiro Ohta, Masahiro Ogawa, and Yasuhiro Nanri
  • Total Pages: 381
  • Publisher: Springer International Publishing
  • ISBN: 9789811055409
• [Book] Proceedings of 31st Symposium of the Collegium Internationale Allergologicum (2018)
  • Author(s): Kenji Izuhara, Shoichi Suzuki, Masahiro Ogawa, Shoichiro Ohta, and Yasuhiro Nanri
  • Total Pages: 112
  • Publisher: Pacini Editore S.r.l.
  • ISBN: 9788833790060
• [Book] The role of pendrin in the airways: Links with asthma and COPD, in The Role of Pendrin in Health and Disease (2017)
  • Author(s): 127.Kenji Izuhara, Shoichi Suzuki, Charity Nofziger, Masahiro Ogawa, Shoichiro Ohta, Yasuhiro Nanri, Yasutaka Mitamura, Tomohito Yoshihara, Nicoletta Pedemonte, Luis J. V. Galietta, and Markus Paulmichl
  • Total Pages: 226
  • Publisher: Springer International Publishing
  • ISBN: 9783319432878
• [Book] Allergies: Current challenges and solutions (2016)
  • Author(s): Izuhara K, Matsumoto H, Nagasaki T, Ohta S, Ono J, and Kinki Hokuriku Airway Disease Conference
  • Total Pages: 240
  • Publisher: Pacini Editore S.r.l.
• [Book] Annual Review 2015 呼吸器 (2015)
  • Author(s): 出原賢治，有馬和彦，太田昭一郎
  • Total Pages: 238
  • Publisher: 中外医学社
• [Remarks] 佐賀大学医学部分子生命科学講座分子医化学分野
  • URL: http://www.biomol.med.saga-u.ac.jp/medbiochem/index.php
• [Patent(Industrial Property Rights)] 試料に含まれるペリオスチンの測定試薬、ペリオスチン測定用前処理剤、ペリオスチン測定方法及びペリオスチン測定の感度の改善方法 (2016)
  • Inventor(s): 太田昭一郎 他
  • Industrial Property Rights Holder: 太田昭一郎 他
  • Industrial Property Rights Type: 特許
  • Filing Date: 2016-08-10
• [Patent(Industrial Property Rights)] 試料中のペリオスチンの測定試薬、ペリオスチン測定用前処理剤、ペリオスチン測定方法及びペリオスチン測定の感度の改善方法 (2016)
  • Inventor(s): 太田昭一郎 他
  • Industrial Property Rights Holder: 太田昭一郎 他
  • Industrial Property Rights Type: 特許
  • Filing Date: 2016-08-10