Treatment strategy of allergy and immunological diseases against MrgX2 expressed on human mast cells as a target molecule for the treatment
| Project/Area Number |
15K09558
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 慢性蕁麻疹 / 皮膚マスト細胞 / substance P / MrgX2 / hemokinin-1 / 関節リウマチ / 滑膜マスト細胞 / chymase / サブスタンスP / カイメース |
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| Outline of Final Research Achievements |
We reported that expression of Mas-related gene X2 (MrgX2), a G-protein coupled receptor, on mast cells was upregulated in the skin of patients with severe chronic urticaria compared with healthy controls. Histamine was released from skin mast cells via MrgX2 in response to substance P, which was released from neuron in response to stress. These results might explain the mechanism of exacerbation of chronic urticaria by stress. MrgX2 is expressed on human synovial mast cells and MrgX2 might be involved in the pathogenesis of rheumatoid arthritis.
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Report
(4 results)
Research Products
(25 results)
