A preliminary study of identification and inhibitive mechanisms of airway regulatory B cells in chronic airway inflammatory diseases

• Project/Area Number: 15K09559
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Collagenous pathology/Allergology
• Research Institution: Kurume University
• Principal Investigator: KAWAYAMA TOMOTAKA 久留米大学, 医学部, 教授 (80289389)
• Research Collaborator: KINOSHITA Takashi 久留米大学, 医学部, 助教 (90454917) ; SAKAZAKI Yuki 久留米大学, 医学部, 助教 (80597386) ; TOKUNAGA Yoshinao 久留米大学, 医学部, 大学院生 (60832722) ; GOUHARA Michi 久留米大学, 医学部, 助教 (00597429)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 制御性B細胞 / 気管支ぜん息 / インターロイキン10 / 気管支喘息 / 気道炎症抑制

Outline of Final Research Achievements

We attempted detection of human IL-10 produced regulated B cells from airway local (induced sputum) and systemic (peripheral blood) using flow cytometry. The frequency of B cell (CD 19 positive) differentiations of the total lymphocytes in induced sputum and peripheral blood in healthy individuals were about 1.0% and 10%, respectively, and there was no significant difference in frequency of B cell differentiations between healthy individuals and asthmatic patients. Furthermore, the IL-10 produced regulatory B cell differentiations peripheral blood were about 0.6% of B lymphocytes, and there was no difference in frequency of regulatory B cell differentiations between healthy individuals and asthmatic patients.

Research Products

• [Journal Article] Successful Treatment of Rapidly Progressive Unclassifiable Idiopathic Interstitial Pneumonia with Anti-melanoma Differentiation-associated Gene-5 Antibody by Intensive Immunosuppressive Therapy (2018)
  • Author(s): Koga T, Kaieda S, Okamoto M, Masuda K, Fujimoto K, Sakamoto S, Nakamura M, Tominaga M, Kawayama T, Fujimoto K, Hoshino T, Ida H.
  • Journal Title: Internal Medicine Volume: 57 Issue: 7 Pages: 1039-1043
  • DOI: 10.2169/internalmedicine.9553-17
  • NAID: 130006602620
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] COPDの初期診断はこうすべき (2018)
  • Author(s): 川山智隆、木下隆、富永芳和
  • Journal Title: 医学書院 Volume: 55 Pages: 45-50
• [Journal Article] How do we critically use long-acting muscarinic receptor antagonists and beta-adrenergic receptor agonists monotherapy, or these combination therapies depending on the situation in Japanese patients with COPD? (2017)
  • Author(s): Kawayama T, Sasaki J.
  • Journal Title: Respir Investig Volume: 55 Issue: 6 Pages: 323-325
  • DOI: 10.1016/j.resinv.2017.09.002
  • Peer Reviewed
• [Journal Article] Dental Technicians' Pneumoconiosis (2017)
  • Author(s): Okamoto M, Tominaga M, Shimizu S, Yano C, Masuda K, Nakamura M, Zaizen Y, Nouno T, Sakamoto S, Yokoyama M, Kawayama T, Hoshino T.
  • Journal Title: Internal Medicine Volume: 56 Issue: 24 Pages: 3323-3326
  • DOI: 10.2169/internalmedicine.8860-17
  • NAID: 130006250538
  • ISSN: 0918-2918, 1349-7235
• [Journal Article] Overexpression of IL-38 protein in anticancer drug-induced lung injury and acute exacerbation of idiopathic pulmonary fibrosis (2017)
  • Author(s): Tominaga Masaki、Okamoto Masaki、Kawayama Tomotaka、Matsuoka Masanobu、Kaieda Shinjiro、Sakazaki Yuki、Kinoshita Takashi、Mori Daisuke、Inoue Akira、Hoshino Tomoaki
  • Journal Title: Respiratory Investigation Volume: 55 Issue: 5 Pages: 293-299
  • DOI: 10.1016/j.resinv.2017.06.001
  • Peer Reviewed / Open Access
• [Journal Article] High Detection Rates of Urine <i>Mycobacterium tuberculosis</i> in Patients with Suspected Miliary Tuberculosis (2017)
  • Author(s): Yokoyama T, Kinoshita T, Okamoto M, Matsunaga K, Kamimura T, Kinoshita M, Rikimaru T, Taguchi K, Hoshino T, Kawayama T.
  • Journal Title: Internal Medicine Volume: 56 Issue: 8 Pages: 895-902
  • DOI: 10.2169/internalmedicine.56.7792
  • NAID: 130006857579
  • ISSN: 0918-2918, 1349-7235
• [Journal Article] Poor pharmacological adherence to inhaled medicines compared with oral medicines in Japanese patients with asthma and chronic obstructive pulmonary disease (2017)
  • Author(s): Imamura Y, Kawayama T, Kinoshita T, Sakazaki Y, Yoshida M, Takahashi K, Fujii K, Ando M, Hoshino T, Iwanaga T, Kohrogi H; Kyushu Asthma Seminar Investigators.
  • Journal Title: Allergology International Volume: 66 Issue: 3 Pages: 482-484
  • DOI: 10.1016/j.alit.2016.10.008
  • NAID: 130005858878
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] COPDの増悪の薬物療法 (2017)
  • Author(s): 木下隆、井上譲、川山智隆、星野友昭
  • Journal Title: 呼吸器内科 Volume: 31 Pages: 533-540
• [Journal Article] Asthma-COPD overlap (ACO) (2017)
  • Author(s): 木下隆、川山智隆、佐々木潤、富永芳和、星野友昭
  • Journal Title: 臨床と研究 Volume: 94 Pages: 1402-1408
• [Journal Article] Evaluation of the Modified Medical Research Council Dyspnea Scale for Predicting Hospitalization and Exacerbation in Japanese Patients with Chronic Obstructive Pulmonary Disease (2016)
  • Author(s): Natori H, Kawayama T, Suetomo M, Kinoshita T, Matsuoka M, Matsunaga K, Okamoto M, Hoshino T.
  • Journal Title: Internal Medicine Volume: 55 Issue: 1 Pages: 15-24
  • DOI: 10.2169/internalmedicine.55.4490
  • NAID: 130005116788
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] "Frequent exacerbator" is a phenotype of poor prognosis in Japanese patients with chronic obstructive pulmonary disease. (2016)
  • Author(s): Tomioka R, Kawayama T, Suetomo M, Kinoshita T, Tokunaga Y, Imaoka H, Matsunaga K, Okamoto M, Hoshino T.
  • Journal Title: Int J Chron Obstruct Pulmon Dis Volume: 11 Pages: 207-216
  • DOI: 10.2147/copd.s98205
  • Peer Reviewed / Open Access
• [Journal Article] Responsiveness of blood and sputum inflammatory cells in Japanese COPD patients, non-COPD smoking controls, and non-COPD nonsmoking controls. (2016)
  • Author(s): Kawayama T, Kinoshita T, Matsunaga K, Kobayashi A, Hayamizu T, Johnson M, Hoshino T.
  • Journal Title: Int J Chron Obstruct Pulmon Dis Volume: 11 Pages: 295-303
  • DOI: 10.2147/copd.s95686
  • Peer Reviewed / Open Access
• [Presentation] 会長特別シンポジウム「喘息・COPDガイドライン一気見」COPDガイドライン第５版 (2018)
  • Author(s): 川山智隆
  • Organizer: 第58回日本呼吸器学会学術集会
  • Invited
• [Presentation] シンポジウムCOPD up-date「COPDにおけるICSの位置づけ」 (2017)
  • Author(s): 川山智隆
  • Organizer: 第57回日本呼吸器学会学術講演会
  • Invited
• [Book] COPD（慢性閉塞性肺疾患）診断と治療のためのガイドライン2018 第5版 (2018)
  • Author(s): 日本呼吸器学会（共著）川山智隆
  • Total Pages: 169
  • Publisher: メディカルレビュー社
  • ISBN: 9784779220746
• [Book] 呼吸器疾患診断治療アプローチ「気管支喘息」 (2017)
  • Author(s): 三嶋理晃、井上博雅（共著）川山智隆
  • Total Pages: 384
  • Publisher: 中山書店
  • ISBN: 9784521745251