Study of the protective immune mechanism against tuberculosis through pDC activation induced by CpG-ODN and Mycobacterium tuberculosis antigen
| Project/Area Number |
15K09565
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | University of Fukui |
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Principal Investigator |
Suzuki Fumiko 福井大学, 学術研究院医学系部門, 特命助教 (80291376)
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| Co-Investigator(Kenkyū-buntansha) |
島田 一郎 福井大学, 学術研究院医学系部門, 教授 (20272908)
西山 晃史 新潟大学, 医歯学系, 講師 (80452069)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUMOTO Sohkichi 新潟大学, 医歯学系, 教授 (30244073)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 結核 / CpGオリゴDNA / 形質細胞様樹状細胞 / 骨髄系樹状細胞 / 共刺激分子 |
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| Outline of Final Research Achievements |
The major protein of Mycobacterium tuberculosis, “M”, is expressed both in the growth phase and in the resting phase. On the other hand, the palindromic deoxyoligonucleotide, “G”, containing a CpG motif induces the activation of plasmacytoid dendritic cells (pDCs). Human peripheral mononuclear cells co-cultured with a combination of “M” and “G” showed enhanced IFN-α production from the pDCs and upregulation of costimulators on the surface of dendritic cells (DCs). It is suggested that both increases in IFN-α production and costimulator expression are dependent on efficient transfer of “G” to DCs mediated by “M”.
The synergistic immune mechanism induced by the combination of “M” antigen and “G” adjuvant is valuable as the scientific basis for the development of new vaccines against tuberculosis.
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Report
(4 results)
Research Products
(7 results)
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[Presentation] The effects of booster vaccine composed of MDP1 and G9.1 against tuberculosis in cynomogus monkeys2018
Author(s)
Daisuke Hayashi, Jun-ichi Maeyama, Toshiko Yamamoto, Toshio Yamazaki, Tetsu Mukai, Toshiki Tamura, Sachi Okabayashi, Fumiko Suzuki, Yuriko Ozeki, Akira Yokoyama, Yuriko Suzaki, Yasushi Ami, Yoshitaka Goto, Sumiko Iho, Sohkichi Matsumoto and Saburo Yamamoto
Organizer
The U.S.-Japan Cooperative Medical Sciences Program, 52nd Mycobacteria Panel Meeting
Related Report
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