Immunonutritional therapy by induced gamma delta T cell in patients with cancer chemotherapy

• Project/Area Number: 15K09570
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Infectious disease medicine
• Research Institution: Kagawa University
• Principal Investigator: Imataki Osamu 香川大学, 医学部附属病院, 講師 (60437697)
• Co-Investigator(Kenkyū-buntansha): 植村 麻希子 香川大学, 医学部, 助教 (00710188)
• Project Period (FY): 2015-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2018: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: adaptive cell therapy / γδT細胞 / 細胞免疫療法 / がん化学療法 / 自然免疫 / 腫瘍免疫 / 感染症 / 免疫不全 / 日和見感染症 / 獲得免疫

Outline of Final Research Achievements

Among the lymphocyte fractions in the tumor cells of patients undergoing cancer chemotherapy for hematological malignancies, helper T cells and B cells significantly affected patients’ survival. γδT cells are a very small component in these lymphocyte fractions, and their effects on clinical outcome were not fully analyzed.

Academic Significance and Societal Importance of the Research Achievements

腫瘍組織局所の免疫状態はがん種によって異なると考えられた。また骨髄内と腫瘍組織において増殖する細胞も異なっていた。血液悪性腫瘍においては生存に寄与する骨髄内リンパ球分画が見いだせなかったが、腫瘍組織において正常のヘルパーT細胞やB細胞の浸潤が予後に関連している可能性が考えられた。

Research Products

• [Journal Article] Nonclonal chromosomal alterations and poor survival in cytopenic patients without hematological malignancies (2019)
  • Author(s): Imataki Osamu、Kubo Hiroyuki、Takeuchi Akihiro、Uemura Makiko、Kadowaki Norimitsu
  • Journal Title: Molecular Cytogenetics Volume: 12 Issue: 1 Pages: 46-46
  • DOI: 10.1186/s13039-019-0458-9
  • Peer Reviewed / Open Access
• [Journal Article] Effect of ultrasound-guided central venous catheter insertion on the incidence of catheter-related bloodstream infections and mechanical complications (2019)
  • Author(s): Imataki Osamu、Shimatani Mami、Ohue Yukiko、Uemura Makiko
  • Journal Title: BMC Infectious Diseases Volume: 19 Issue: 1 Pages: 857-857
  • DOI: 10.1186/s12879-019-4487-0
  • Peer Reviewed / Open Access
• [Journal Article] Diagnostic Value of Flow Cytometry Standardized Using the European LeukemiaNet for Myelodysplastic Syndrome (2019)
  • Author(s): Takeuchi Akihiro、Imataki Osamu、Kubo Hiroyuki、Kondo Akihiro、Seo Kayoko、Uemura Makiko、Yamaoka Genji、Murao Koji、Takeuchi Akihiro
  • Journal Title: Acta Haematologica Volume: 143 Issue: 2 Pages: 140-145
  • DOI: 10.1159/000501147
  • Peer Reviewed
• [Journal Article] Lethal cardiac damage resulting from eosinophilia caused by anaplastic large cell lymphoma (2019)
  • Author(s): Imataki Osamu、Uemura Makiko、Kadowaki Norimitsu
  • Journal Title: British Journal of Haematology Volume: 185 Issue: 4 Pages: 642-642
  • DOI: 10.1111/bjh.15809
  • Peer Reviewed
• [Journal Article] c-D-index is a risk factor for prolonged febrile neutropenia during chemotherapy in patients with acute myeloid leukemia. (2019)
  • Author(s): Kubo Hiroyuki, Imataki Osama, Kubo Yukiko, Uemura M, Kadowaki N.
  • Journal Title: nt J Clin Oncol Volume: 24 Issue: 5 Pages: 590-595
  • DOI: 10.1007/s10147-018-01384-9
  • Peer Reviewed
• [Journal Article] Bendamustine and G-CSF support (2018)
  • Author(s): Imataki Osamu、Uchida Shumpei、Yokokura Shigeyuki、Uemura Makiko、Kadowaki Norimitsu
  • Journal Title: Supportive Care in Cancer Volume: 27 Issue: 5 Pages: 1581-1582
  • DOI: 10.1007/s00520-018-4118-0
  • Peer Reviewed
• [Journal Article] Lemongrass essential oil and citral inhibit Src/Stat3 activity and suppress the proliferation/survival of small-cell lung cancer cells, alone or in combination with chemotherapeutic agents (2018)
  • Author(s): Maruoka Takayuki、Kitanaka Akira、Kubota Yoshitsugu、Yamaoka Genji、Kameda Tomohiro、Imataki Osamu、Dobashi Hiroaki、Bandoh Shuji、Kadowaki Norimitsu、Tanaka Terukazu
  • Journal Title: International Journal of Oncology Volume: -
  • DOI: 10.3892/ijo.2018.4314
  • Peer Reviewed
• [Journal Article] Voriconazole concentration is inversely correlated with corticosteroid usage in immunocompromised patients (2018)
  • Author(s): Imataki Osamu、Yamaguchi Kazunori、Uemura Makiko、Fukuoka Noriyasu
  • Journal Title: Transplant Infectious Disease Volume: 20 Issue: 4
  • DOI: 10.1111/tid.12886
  • Peer Reviewed
• [Journal Article] Pure erythroid leukemia in a polymyositis patient treated with azathioprine (2018)
  • Author(s): Imataki Osamu、Takeuchi Akihiro、Uchida Shumpei、Yokokura Shigeyuki、Uemura Makiko、Kadowaki Norimitsu
  • Journal Title: Rare Tumors Volume: 10
  • DOI: 10.1177/2036361318773847
  • Peer Reviewed / Open Access
• [Journal Article] B-chronic lymphocytic leukemia showed triple transformation, to diffuse large B cell, CD20-negative, and T-cell neoplasm during ofatumumab treatment: a case report (2018)
  • Author(s): Imataki Osamu、Uemura Makiko
  • Journal Title: BMC Clinical Pathology Volume: 18 Issue: 1
  • DOI: 10.1186/s12907-018-0072-5
  • Peer Reviewed / Open Access
• [Journal Article] Asymptomatic hepatosplenomegaly in chronic myeloid leukemia. (2018)
  • Author(s): Imataki Osamu、Uemura Makiko
  • Journal Title: Oxf Med Case Reports Volume: 10 Pages: 48-48
  • Peer Reviewed / Open Access
• [Journal Article] Central Nervous System Peripheral T Cell Lymphoma Manifesting as Lymphomatosis Cerebri That Was Misdiagnosed as Neuro-Beh?et’s Disease: A Case Report (2018)
  • Author(s): Imataki Osamu、Uchida Shumpei、Yokokura Shigeyuki、Uemura Makiko、Kadowaki Norimitsu
  • Journal Title: Case Reports in Oncology Volume: 11 Issue: 3 Pages: 806-813
  • DOI: 10.1159/000495033
  • Peer Reviewed / Open Access
• [Journal Article] Anemia and hypogammaglobulinemia caused by Ménétrier's disease. (2017)
  • Author(s): Imataki O, Uchida S, Yokokura S, Uemura M, Kadowaki N.
  • Journal Title: Int J Hematol. Volume: 107 Issue: 1 Pages: 3-4
  • DOI: 10.1007/s12185-017-2349-3
  • Peer Reviewed
• [Journal Article] Enteral Malakoplakia Prior to Helicobacter cinaedi Bacteremia. (2017)
  • Author(s): Imataki O, Kawashima K, Uchida S, Yokokura S, Uemura M, Kadowaki N.
  • Journal Title: Am J Gastroenterol Volume: 112 Issue: 1 Pages: 187-188
  • DOI: 10.1038/ajg.2016.514
  • Peer Reviewed
• [Journal Article] Nutritional risk in allogeneic stem cell transplantation: rationale for a tailored nutritional pathway. (2017)
  • Author(s): Aoyama T, Imataki O, Mori K, Yoshitsugu K, Fukaya M, Okamura I, Enami T, Tatara R, Ikeda T.
  • Journal Title: Ann Hematol. Volume: 96 Issue: 4 Pages: 617-625
  • DOI: 10.1007/s00277-016-2910-9
  • Peer Reviewed
• [Journal Article] Low-dose anti-thymocyte globulin reduce severe acute and chronic graft-versus-host disease after allogeneic stem cell transplantation. (2017)
  • Author(s): Imataki O, Matsumoto K, Uemura M.
  • Journal Title: J Cancer Res Clin Oncol Volume: 143 Issue: 4 Pages: 709-715
  • DOI: 10.1007/s00432-016-2329-7
  • Peer Reviewed
• [Journal Article] Fatal Rhabdomyolysis Caused by <i>Morganella morganii</i> in a Patient with Multiple Myeloma (2017)
  • Author(s): Imataki O, Uemura M.
  • Journal Title: Internal Medicine Volume: 56 Issue: 3 Pages: 369-371
  • DOI: 10.2169/internalmedicine.56.7252
  • NAID: 130005310321
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] Bladder Rupture After Chronic Hemorrhagic Cystitis in a Stem Cell Transplantation Recipient. (2017)
  • Author(s): Imataki O, Uchida S, Kushida Y, Uemura M.
  • Journal Title: Transplantation Volume: 101 Issue: 8 Pages: e280-e281
  • DOI: 10.1097/tp.0000000000001810
  • Peer Reviewed
• [Journal Article] Acquired Inhibitors to Multiple Coagulation Factors (V, IX, and XII) Identified in a Unique Patient with Hepatocellular Carcinoma (2017)
  • Author(s): Imataki O, Arai T, Uemura M.
  • Journal Title: Internal Medicine Volume: 56 Issue: 10 Pages: 1203-1206
  • DOI: 10.2169/internalmedicine.56.7845
  • NAID: 130006858075
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] Methionine PET Might Be Reliable for the Detection of Low M-Protein-Producing Myelomas. (2017)
  • Author(s): Imataki O, Uchida S, Yokokura S, Uemura M, Kadowaki N.
  • Journal Title: Clin Nucl Med. Volume: 42 Issue: 11 Pages: e469-e471
  • DOI: 10.1097/rlu.0000000000001821
  • Peer Reviewed
• [Journal Article] Complete mimicry: a case of alveolar rhabdomyosarcoma masquerading as acute leukemia. (2017)
  • Author(s): Imataki O, Uemura M, Uchida S, Yokokura S, Takeuchi A, Ishikawa R, Kondo A, Seo K, Kadowaki N.
  • Journal Title: Diagn Pathol Volume: 12 Issue: 1 Pages: 77-77
  • DOI: 10.1186/s13000-017-0667-7
  • Peer Reviewed
• [Journal Article] Strain-specific transmission in an outbreak of ESBL-producing Enterobacteriaceae in the hemato-oncology care unit: a cohort study. (2016)
  • Author(s): Uemura M, Imataki O, Uchida S, Nakayama-Imaohji H, Ohue Y, Matsuka H, Mori H, Dobashi H, Kuwahara T, Kadowaki N.
  • Journal Title: BMC Infect Dis Volume: 17 Issue: 1 Pages: 26-26
  • DOI: 10.1186/s12879-016-2144-4
  • Peer Reviewed / Open Access
• [Journal Article] Tanaka S, Imataki O, Kitaoka A, Fujioka S, Hanabusa E, Ohbayashi Y, Uemura M, Arima N, Yamamoto T. (2016)
  • Author(s): Clinical impact of sarcopenia and relevance of nutritional intake in patients before and after allogeneic hematopoietic stem cell transplantation.
  • Journal Title: J Cancer Res Clin Oncol Volume: 143 Issue: 6 Pages: 2336-2338
  • DOI: 10.1007/s00432-016-2336-8
  • Peer Reviewed
• [Journal Article] CDR3β sequence motifs regulate autoreactivity of human invariant NKT cell receptors. (2016)
  • Author(s): Chamoto K, Guo T, Imataki O, Tanaka M, Nakatsugawa M, Ochi T, Yamashita Y, Saito AM, Saito TI, Butler MO, Hirano N.
  • Journal Title: J Autoimmun Volume: 68 Pages: 39-51
  • DOI: 10.1016/j.jaut.2015.12.005
  • Peer Reviewed
• [Journal Article] Neurotropic infiltration and neuropathy of multifocal lymphoma. (2016)
  • Author(s): Imataki O, Kida J, Yokohira M, Uemura M.
  • Journal Title: Support Care Cancer Volume: 24 Issue: 5 Pages: 1939-1940
  • DOI: 10.1007/s00520-016-3098-1
  • Peer Reviewed
• [Journal Article] Antilymphocyte Globulin for Chronic Graft-versus-Host Disease. (2016)
  • Author(s): Imataki O, Uemura M, Kadowaki N.
  • Journal Title: N Engl J Med Volume: 374 Issue: 19 Pages: 1894-1894
  • DOI: 10.1056/nejmc1601364
  • Peer Reviewed
• [Journal Article] Perforation in an intestinal malignant lymphoma case. (2016)
  • Author(s): Imataki O, Shiroshita K, Uchida S, Kida J, Akamoto S, Uemura M.
  • Journal Title: BMC Res Notes Volume: 9 Issue: 1 Pages: 308-308
  • DOI: 10.1186/s13104-016-2111-6
  • Peer Reviewed / Open Access
• [Journal Article] The Leading Seafood Cuisine of Anisakidosis in Japan. (2016)
  • Author(s): Imataki O, Bandoh S, Kawakami K, Uemura M.
  • Journal Title: Clin Infect Dis Volume: 62 Issue: 12 Pages: 1612-1613
  • DOI: 10.1093/cid/ciw196
  • Peer Reviewed
• [Journal Article] Fatal acute respiratory distress syndrome after stem cell infusion. (2016)
  • Author(s): Imataki O, Ura K, Uemura M.
  • Journal Title: Transfus Med. Volume: 26 Issue: 5 Pages: 387-389
  • DOI: 10.1111/tme.12336
  • Peer Reviewed
• [Journal Article] Chromosomal abnormality of acute promyelocytic leukemia other than PML-RARA: a case report of acute promyelocytic leukemia with del(5q). (2016)
  • Author(s): Imataki O, Uemura M.
  • Journal Title: BMC Clin Pathol. Volume: 16 Pages: 16-16
  • Peer Reviewed
• [Journal Article] Charlson comorbidity index predicts poor outcome in CML patients treated with tyrosine kinase inhibitor. (2016)
  • Author(s): Uemura M, Imataki O, Kawachi Y, Kawakami K, Hoshijima Y, Matsuoka A, Kadowaki N.
  • Journal Title: Int J Hematol. Volume: 104 Pages: 621-627
  • Peer Reviewed
• [Journal Article] Bone Marrow and Peripheral Blood: Which Is Safe? (2016)
  • Author(s): Imataki O, Uchida S, Yokokura S, Uemura M, Matsushita K, Kadowaki N.
  • Journal Title: Biol Blood Marrow Transplant Volume: 22 Issue: 12 Pages: 283-2284
  • DOI: 10.1016/j.bbmt.2016.09.015
  • Peer Reviewed
• [Journal Article] Chryseobacterium indologenes, a possible emergent organism resistant to carbapenem antimicrobials after stem cell transplantation. (2016)
  • Author(s): Imataki O, Uemura M.
  • Journal Title: Clin Case Rep Volume: 5 Issue: 1 Pages: 22-25
  • DOI: 10.1002/ccr3.753
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Paradoxical thrombosis in idiopathic thrombocytopenic purpura. (2016)
  • Author(s): Imataki O, Uchida S, Yokokura S, Uemura M, Kadowaki N.
  • Journal Title: Int J Hematol Volume: 105 Issue: 2 Pages: 111-112
  • DOI: 10.1007/s12185-016-2117-9
  • Peer Reviewed
• [Journal Article] Marked Hematopoiesis Masquerading Multiple Bone Metastasis in a Lung Cancer Patient With Myelodysplastic Syndrome. (2015)
  • Author(s): Imataki O, Uchida S, Shiroshita K, Kida J, Uemura M.
  • Journal Title: Clin Nucl Med Volume: 40 Issue: 7 Pages: 574-575
  • DOI: 10.1097/rlu.0000000000000698
  • Peer Reviewed
• [Journal Article] Anti-CD30 antibody-induced radiation recall reaction: a collateral target for activated lymphocytes. (2015)
  • Author(s): Imataki O, Kubo H, Hamasaki Y, Oku M, Kida J, Uemura M.
  • Journal Title: Ann Pharmacother. 2015 Aug;49(8):947-8 Volume: 49 Issue: 8 Pages: 947-948
  • DOI: 10.1177/1060028015589169
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Ganciclovir-resistant HHV-6 encephalitis that progressed rapidly after bone marrow transplantation. (2015)
  • Author(s): Imataki O, Uemura M.
  • Journal Title: J Clin Virol Volume: 69 Pages: 176-178
  • DOI: 10.1016/j.jcv.2015.06.097
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Persistent Left Superior Vena Cava in Hematological Malignancy Requiring Central Venous Catheter Insertion for Intensive Chemotherapy. (2015)
  • Author(s): Imataki O, Kubo H, Hamasaki Y, Oku M, Kida J, Uemura M, Matsuka H.
  • Journal Title: Case Rep Oncol Volume: 8 Issue: 3 Pages: 478-481
  • DOI: 10.1159/000441836