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Immunonutritional therapy by induced gamma delta T cell in patients with cancer chemotherapy

Research Project

Project/Area Number 15K09570
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Infectious disease medicine
Research InstitutionKagawa University

Principal Investigator

Imataki Osamu  香川大学, 医学部附属病院, 講師 (60437697)

Co-Investigator(Kenkyū-buntansha) 植村 麻希子  香川大学, 医学部, 助教 (00710188)
Project Period (FY) 2015-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsadaptive cell therapy / γδT細胞 / 細胞免疫療法 / がん化学療法 / 自然免疫 / 腫瘍免疫 / 感染症 / 免疫不全 / 日和見感染症 / 獲得免疫
Outline of Final Research Achievements

Among the lymphocyte fractions in the tumor cells of patients undergoing cancer chemotherapy for hematological malignancies, helper T cells and B cells significantly affected patients’ survival. γδT cells are a very small component in these lymphocyte fractions, and their effects on clinical outcome were not fully analyzed.

Academic Significance and Societal Importance of the Research Achievements

腫瘍組織局所の免疫状態はがん種によって異なると考えられた。また骨髄内と腫瘍組織において増殖する細胞も異なっていた。血液悪性腫瘍においては生存に寄与する骨髄内リンパ球分画が見いだせなかったが、腫瘍組織において正常のヘルパーT細胞やB細胞の浸潤が予後に関連している可能性が考えられた。

Report

(6 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (38 results)

All 2019 2018 2017 2016 2015

All Journal Article (38 results) (of which Peer Reviewed: 37 results,  Open Access: 10 results,  Acknowledgement Compliant: 3 results)

  • [Journal Article] Nonclonal chromosomal alterations and poor survival in cytopenic patients without hematological malignancies2019

    • Author(s)
      Imataki Osamu、Kubo Hiroyuki、Takeuchi Akihiro、Uemura Makiko、Kadowaki Norimitsu
    • Journal Title

      Molecular Cytogenetics

      Volume: 12 Issue: 1 Pages: 46-46

    • DOI

      10.1186/s13039-019-0458-9

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of ultrasound-guided central venous catheter insertion on the incidence of catheter-related bloodstream infections and mechanical complications2019

    • Author(s)
      Imataki Osamu、Shimatani Mami、Ohue Yukiko、Uemura Makiko
    • Journal Title

      BMC Infectious Diseases

      Volume: 19 Issue: 1 Pages: 857-857

    • DOI

      10.1186/s12879-019-4487-0

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diagnostic Value of Flow Cytometry Standardized Using the European LeukemiaNet for Myelodysplastic Syndrome2019

    • Author(s)
      Takeuchi Akihiro、Imataki Osamu、Kubo Hiroyuki、Kondo Akihiro、Seo Kayoko、Uemura Makiko、Yamaoka Genji、Murao Koji、Takeuchi Akihiro
    • Journal Title

      Acta Haematologica

      Volume: 143 Issue: 2 Pages: 140-145

    • DOI

      10.1159/000501147

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lethal cardiac damage resulting from eosinophilia caused by anaplastic large cell lymphoma2019

    • Author(s)
      Imataki Osamu、Uemura Makiko、Kadowaki Norimitsu
    • Journal Title

      British Journal of Haematology

      Volume: 185 Issue: 4 Pages: 642-642

    • DOI

      10.1111/bjh.15809

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] c-D-index is a risk factor for prolonged febrile neutropenia during chemotherapy in patients with acute myeloid leukemia.2019

    • Author(s)
      Kubo Hiroyuki, Imataki Osama, Kubo Yukiko, Uemura M, Kadowaki N.
    • Journal Title

      nt J Clin Oncol

      Volume: 24 Issue: 5 Pages: 590-595

    • DOI

      10.1007/s10147-018-01384-9

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bendamustine and G-CSF support2018

    • Author(s)
      Imataki Osamu、Uchida Shumpei、Yokokura Shigeyuki、Uemura Makiko、Kadowaki Norimitsu
    • Journal Title

      Supportive Care in Cancer

      Volume: 27 Issue: 5 Pages: 1581-1582

    • DOI

      10.1007/s00520-018-4118-0

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lemongrass essential oil and citral inhibit Src/Stat3 activity and suppress the proliferation/survival of small-cell lung cancer cells, alone or in combination with chemotherapeutic agents2018

    • Author(s)
      Maruoka Takayuki、Kitanaka Akira、Kubota Yoshitsugu、Yamaoka Genji、Kameda Tomohiro、Imataki Osamu、Dobashi Hiroaki、Bandoh Shuji、Kadowaki Norimitsu、Tanaka Terukazu
    • Journal Title

      International Journal of Oncology

      Volume: -

    • DOI

      10.3892/ijo.2018.4314

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Voriconazole concentration is inversely correlated with corticosteroid usage in immunocompromised patients2018

    • Author(s)
      Imataki Osamu、Yamaguchi Kazunori、Uemura Makiko、Fukuoka Noriyasu
    • Journal Title

      Transplant Infectious Disease

      Volume: 20 Issue: 4

    • DOI

      10.1111/tid.12886

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pure erythroid leukemia in a polymyositis patient treated with azathioprine2018

    • Author(s)
      Imataki Osamu、Takeuchi Akihiro、Uchida Shumpei、Yokokura Shigeyuki、Uemura Makiko、Kadowaki Norimitsu
    • Journal Title

      Rare Tumors

      Volume: 10

    • DOI

      10.1177/2036361318773847

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] B-chronic lymphocytic leukemia showed triple transformation, to diffuse large B cell, CD20-negative, and T-cell neoplasm during ofatumumab treatment: a case report2018

    • Author(s)
      Imataki Osamu、Uemura Makiko
    • Journal Title

      BMC Clinical Pathology

      Volume: 18 Issue: 1

    • DOI

      10.1186/s12907-018-0072-5

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Asymptomatic hepatosplenomegaly in chronic myeloid leukemia.2018

    • Author(s)
      Imataki Osamu、Uemura Makiko
    • Journal Title

      Oxf Med Case Reports

      Volume: 10 Pages: 48-48

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Central Nervous System Peripheral T Cell Lymphoma Manifesting as Lymphomatosis Cerebri That Was Misdiagnosed as Neuro-Beh?et’s Disease: A Case Report2018

    • Author(s)
      Imataki Osamu、Uchida Shumpei、Yokokura Shigeyuki、Uemura Makiko、Kadowaki Norimitsu
    • Journal Title

      Case Reports in Oncology

      Volume: 11 Issue: 3 Pages: 806-813

    • DOI

      10.1159/000495033

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anemia and hypogammaglobulinemia caused by Ménétrier's disease.2017

    • Author(s)
      Imataki O, Uchida S, Yokokura S, Uemura M, Kadowaki N.
    • Journal Title

      Int J Hematol.

      Volume: 107 Issue: 1 Pages: 3-4

    • DOI

      10.1007/s12185-017-2349-3

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Enteral Malakoplakia Prior to Helicobacter cinaedi Bacteremia.2017

    • Author(s)
      Imataki O, Kawashima K, Uchida S, Yokokura S, Uemura M, Kadowaki N.
    • Journal Title

      Am J Gastroenterol

      Volume: 112 Issue: 1 Pages: 187-188

    • DOI

      10.1038/ajg.2016.514

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Nutritional risk in allogeneic stem cell transplantation: rationale for a tailored nutritional pathway.2017

    • Author(s)
      Aoyama T, Imataki O, Mori K, Yoshitsugu K, Fukaya M, Okamura I, Enami T, Tatara R, Ikeda T.
    • Journal Title

      Ann Hematol.

      Volume: 96 Issue: 4 Pages: 617-625

    • DOI

      10.1007/s00277-016-2910-9

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Low-dose anti-thymocyte globulin reduce severe acute and chronic graft-versus-host disease after allogeneic stem cell transplantation2017

    • Author(s)
      Imataki O, Matsumoto K, Uemura M.
    • Journal Title

      J Cancer Res Clin Oncol

      Volume: 143 Issue: 4 Pages: 709

    • DOI

      10.1007/s00432-016-2329-7

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fatal Rhabdomyolysis Caused by <i>Morganella morganii</i> in a Patient with Multiple Myeloma2017

    • Author(s)
      Imataki O, Uemura M.
    • Journal Title

      Internal Medicine

      Volume: 56 Issue: 3 Pages: 369-371

    • DOI

      10.2169/internalmedicine.56.7252

    • NAID

      130005310321

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bladder Rupture After Chronic Hemorrhagic Cystitis in a Stem Cell Transplantation Recipient.2017

    • Author(s)
      Imataki O, Uchida S, Kushida Y, Uemura M.
    • Journal Title

      Transplantation

      Volume: 101 Issue: 8 Pages: e280-e281

    • DOI

      10.1097/tp.0000000000001810

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Acquired Inhibitors to Multiple Coagulation Factors (V, IX, and XII) Identified in a Unique Patient with Hepatocellular Carcinoma2017

    • Author(s)
      Imataki O, Arai T, Uemura M.
    • Journal Title

      Internal Medicine

      Volume: 56 Issue: 10 Pages: 1203-1206

    • DOI

      10.2169/internalmedicine.56.7845

    • NAID

      130006858075

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Methionine PET Might Be Reliable for the Detection of Low M-Protein-Producing Myelomas.2017

    • Author(s)
      Imataki O, Uchida S, Yokokura S, Uemura M, Kadowaki N.
    • Journal Title

      Clin Nucl Med.

      Volume: 42 Issue: 11 Pages: e469-e471

    • DOI

      10.1097/rlu.0000000000001821

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Complete mimicry: a case of alveolar rhabdomyosarcoma masquerading as acute leukemia.2017

    • Author(s)
      Imataki O, Uemura M, Uchida S, Yokokura S, Takeuchi A, Ishikawa R, Kondo A, Seo K, Kadowaki N.
    • Journal Title

      Diagn Pathol

      Volume: 12 Issue: 1 Pages: 77-77

    • DOI

      10.1186/s13000-017-0667-7

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Strain-specific transmission in an outbreak of ESBL-producing Enterobacteriaceae in the hemato-oncology care unit: a cohort study.2016

    • Author(s)
      Uemura M, Imataki O, Uchida S, Nakayama-Imaohji H, Ohue Y, Matsuka H, Mori H, Dobashi H, Kuwahara T, Kadowaki N.
    • Journal Title

      BMC Infect Dis

      Volume: 17 Issue: 1 Pages: 26-26

    • DOI

      10.1186/s12879-016-2144-4

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tanaka S, Imataki O, Kitaoka A, Fujioka S, Hanabusa E, Ohbayashi Y, Uemura M, Arima N, Yamamoto T.2016

    • Author(s)
      Clinical impact of sarcopenia and relevance of nutritional intake in patients before and after allogeneic hematopoietic stem cell transplantation.
    • Journal Title

      J Cancer Res Clin Oncol

      Volume: 143 Issue: 6 Pages: 2336-2338

    • DOI

      10.1007/s00432-016-2336-8

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] CDR3β sequence motifs regulate autoreactivity of human invariant NKT cell receptors.2016

    • Author(s)
      Chamoto K, Guo T, Imataki O, Tanaka M, Nakatsugawa M, Ochi T, Yamashita Y, Saito AM, Saito TI, Butler MO, Hirano N.
    • Journal Title

      J Autoimmun

      Volume: 68 Pages: 39-51

    • DOI

      10.1016/j.jaut.2015.12.005

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neurotropic infiltration and neuropathy of multifocal lymphoma.2016

    • Author(s)
      Imataki O, Kida J, Yokohira M, Uemura M.
    • Journal Title

      Support Care Cancer

      Volume: 24 Issue: 5 Pages: 1939-1940

    • DOI

      10.1007/s00520-016-3098-1

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Antilymphocyte Globulin for Chronic Graft-versus-Host Disease.2016

    • Author(s)
      Imataki O, Uemura M, Kadowaki N.
    • Journal Title

      N Engl J Med

      Volume: 374 Issue: 19 Pages: 1894-1894

    • DOI

      10.1056/nejmc1601364

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Perforation in an intestinal malignant lymphoma case.2016

    • Author(s)
      Imataki O, Shiroshita K, Uchida S, Kida J, Akamoto S, Uemura M.
    • Journal Title

      BMC Res Notes

      Volume: 9 Issue: 1 Pages: 308-308

    • DOI

      10.1186/s13104-016-2111-6

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Leading Seafood Cuisine of Anisakidosis in Japan.2016

    • Author(s)
      Imataki O, Bandoh S, Kawakami K, Uemura M.
    • Journal Title

      Clin Infect Dis

      Volume: 62 Issue: 12 Pages: 1612-1613

    • DOI

      10.1093/cid/ciw196

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fatal acute respiratory distress syndrome after stem cell infusion.2016

    • Author(s)
      Imataki O, Ura K, Uemura M.
    • Journal Title

      Transfus Med.

      Volume: 26 Issue: 5 Pages: 387-389

    • DOI

      10.1111/tme.12336

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chromosomal abnormality of acute promyelocytic leukemia other than PML-RARA: a case report of acute promyelocytic leukemia with del(5q).2016

    • Author(s)
      Imataki O, Uemura M.
    • Journal Title

      BMC Clin Pathol.

      Volume: 16 Pages: 16-16

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Charlson comorbidity index predicts poor outcome in CML patients treated with tyrosine kinase inhibitor.2016

    • Author(s)
      Uemura M, Imataki O, Kawachi Y, Kawakami K, Hoshijima Y, Matsuoka A, Kadowaki N.
    • Journal Title

      Int J Hematol.

      Volume: 104 Pages: 621-627

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bone Marrow and Peripheral Blood: Which Is Safe?2016

    • Author(s)
      Imataki O, Uchida S, Yokokura S, Uemura M, Matsushita K, Kadowaki N.
    • Journal Title

      Biol Blood Marrow Transplant

      Volume: 22 Issue: 12 Pages: 283-2284

    • DOI

      10.1016/j.bbmt.2016.09.015

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chryseobacterium indologenes, a possible emergent organism resistant to carbapenem antimicrobials after stem cell transplantation.2016

    • Author(s)
      Imataki O, Uemura M.
    • Journal Title

      Clin Case Rep

      Volume: 5 Issue: 1 Pages: 22-25

    • DOI

      10.1002/ccr3.753

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Paradoxical thrombosis in idiopathic thrombocytopenic purpura.2016

    • Author(s)
      Imataki O, Uchida S, Yokokura S, Uemura M, Kadowaki N.
    • Journal Title

      Int J Hematol

      Volume: 105 Issue: 2 Pages: 111-112

    • DOI

      10.1007/s12185-016-2117-9

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Marked Hematopoiesis Masquerading Multiple Bone Metastasis in a Lung Cancer Patient With Myelodysplastic Syndrome.2015

    • Author(s)
      Imataki O, Uchida S, Shiroshita K, Kida J, Uemura M.
    • Journal Title

      Clin Nucl Med

      Volume: 40 Issue: 7 Pages: 574-575

    • DOI

      10.1097/rlu.0000000000000698

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Anti-CD30 antibody-induced radiation recall reaction: a collateral target for activated lymphocytes.2015

    • Author(s)
      Imataki O, Kubo H, Hamasaki Y, Oku M, Kida J, Uemura M.
    • Journal Title

      Ann Pharmacother. 2015 Aug;49(8):947-8

      Volume: 49 Issue: 8 Pages: 947-948

    • DOI

      10.1177/1060028015589169

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Ganciclovir-resistant HHV-6 encephalitis that progressed rapidly after bone marrow transplantation.2015

    • Author(s)
      Imataki O, Uemura M.
    • Journal Title

      J Clin Virol

      Volume: 69 Pages: 176-178

    • DOI

      10.1016/j.jcv.2015.06.097

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Persistent Left Superior Vena Cava in Hematological Malignancy Requiring Central Venous Catheter Insertion for Intensive Chemotherapy.2015

    • Author(s)
      Imataki O, Kubo H, Hamasaki Y, Oku M, Kida J, Uemura M, Matsuka H.
    • Journal Title

      Case Rep Oncol

      Volume: 8 Issue: 3 Pages: 478-481

    • DOI

      10.1159/000441836

    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2021-02-19  

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