Immunonutritional therapy by induced gamma delta T cell in patients with cancer chemotherapy
| Project/Area Number |
15K09570
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Kagawa University |
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Principal Investigator |
Imataki Osamu 香川大学, 医学部附属病院, 講師 (60437697)
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| Co-Investigator(Kenkyū-buntansha) |
植村 麻希子 香川大学, 医学部, 助教 (00710188)
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| Project Period (FY) |
2015-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | adaptive cell therapy / γδT細胞 / 細胞免疫療法 / がん化学療法 / 自然免疫 / 腫瘍免疫 / 感染症 / 免疫不全 / 日和見感染症 / 獲得免疫 |
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| Outline of Final Research Achievements |
Among the lymphocyte fractions in the tumor cells of patients undergoing cancer chemotherapy for hematological malignancies, helper T cells and B cells significantly affected patients’ survival. γδT cells are a very small component in these lymphocyte fractions, and their effects on clinical outcome were not fully analyzed.
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| Academic Significance and Societal Importance of the Research Achievements |
腫瘍組織局所の免疫状態はがん種によって異なると考えられた。また骨髄内と腫瘍組織において増殖する細胞も異なっていた。血液悪性腫瘍においては生存に寄与する骨髄内リンパ球分画が見いだせなかったが、腫瘍組織において正常のヘルパーT細胞やB細胞の浸潤が予後に関連している可能性が考えられた。
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Report
(6 results)
Research Products
(38 results)
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[Journal Article] CDR3β sequence motifs regulate autoreactivity of human invariant NKT cell receptors.2016
Author(s)
Chamoto K, Guo T, Imataki O, Tanaka M, Nakatsugawa M, Ochi T, Yamashita Y, Saito AM, Saito TI, Butler MO, Hirano N.
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Journal Title
J Autoimmun
Volume: 68
Pages: 39-51
DOI
Related Report
Peer Reviewed
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