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Development of novel therapeutic strategies to overcome refractory fungal infections

Research Project

Project/Area Number 15K09573
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Infectious disease medicine
Research InstitutionNagasaki University

Principal Investigator

MIYAZAKI Taiga  長崎大学, 医歯薬学総合研究科(医学系), 講師 (60448496)

Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords抗真菌薬 / 抗真菌薬耐性
Outline of Final Research Achievements

In the context of limited availability of antifungal agents, the emergence of multidrug resistant isolates has become a critical issue in clinical settings, underscoring an urgent need for the development of new antifungal strategies.
In this study, we have elucidated the resistant mechanisms of multidrug resistant Candida glabrata and the clinical and microbiological characteristics of Candida guilliermondii infections. In addition, we performed high-throughput screening of chemical compound libraries and found a novel compound that had potent antifungal activities.

Academic Significance and Societal Importance of the Research Achievements

侵襲性真菌感染症は致死的な経過をとることも少なくない。治療薬が少ないなかで耐性菌の出現が問題となっている。今回、耐性化のメカニズムや耐性菌感染症の臨床的および微生物学的特徴を一部解明した。また、化合物ライブラリーのスクリーニングにより、病原真菌に有効な新規化合物を同定することができた。これらの研究成果は、今後の新薬開発に寄与するものと考える。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (22 results)

All 2019 2018 2017 2016 2015

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (15 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Journal Article] Clinical and Microbiological Characteristics of Candida guilliermondii and Candida fermentati2018

    • Author(s)
      Hirayama Tatsuro、Miyazaki Taiga、Yamagishi Yuka、Mikamo Hiroshige、et al.
    • Journal Title

      Antimicrobial Agents and Chemotherapy

      Volume: 印刷中 Issue: 6 Pages: 02528-17

    • DOI

      10.1128/aac.02528-17

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Unexpected effects of azole transporter inhibitors on antifungal susceptibility in Candida glabrata and other pathogenic Candida species2017

    • Author(s)
      Nagayoshi Yohsuke、Miyazaki Taiga、Shimamura Shintaro、Nakayama Hironobu、Minematsu Asuka、Yamauchi Shunsuke、Takazono Takahiro、Nakamura Shigeki、Yanagihara Katsunori、Kohno Shigeru、Mukae Hiroshi、Izumikawa Koichi
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 7 Pages: e0180990-e0180990

    • DOI

      10.1371/journal.pone.0180990

    • NAID

      120006987443

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] T-2307, a novel arylamidine, is transported into Candida albicans by a high-affinity spermine and spermidine carrier regulated by Agp2.2016

    • Author(s)
      Nishikawa H, Sakagami T, Yamada E, Fukuda Y, Hayakawa H, Nomura N, Mitsuyama J, Miyazaki T, Mukae H, Kohno S.
    • Journal Title

      J Antimicrob Chemother.

      Volume: 印刷中

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] The risk factors for developing of chronic pulmonary aspergillosis in nontuberculous mycobacteria patients and clinical characteristics and outcomes in chronic pulmonary aspergillosis patients coinfected with nontuberculous mycobacteria.2016

    • Author(s)
      Takeda K, Imamura Y, Takazono T, Yoshida M, Ide S, Hirano K, Tashiro M, Saijo T, Kosai K, Morinaga Y, Nakamura S, Kurihara S, Tsukamoto M, Miyazaki T, Tashiro T, Kohno S, Yanagihara K, Izumikawa K.
    • Journal Title

      Med Mycol.

      Volume: 54 Issue: 2 Pages: 120-127

    • DOI

      10.1093/mmy/myv093

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Toll-like Receptor 4 Agonistic Antibody Promotes Host Defense against Chronic Pseudomonas aeruginosa Lung Infection in Mice.2016

    • Author(s)
      Nakamura S, Iwanaga N, Seki M, Fukudome K, Oshima K, Miyazaki T, Izumikawa K, Yanagihara K, Miyazaki Y, Mukae H, Kohno S.
    • Journal Title

      Infect Immun.

      Volume: 印刷中

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Current recommendations and importance of antifungal stewardship for the management of invasive candidiasis.2015

    • Author(s)
      Miyazaki T, Kohno S
    • Journal Title

      Expert Rev Anti Infect Ther.

      Volume: 13 Issue: 9 Pages: 1171-1183

    • DOI

      10.1586/14787210.2015.1058157

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Macrolides promote CCL2-mediated macrophage recruitment and clearance of nasopharyngeal pneumococcal colonies in mice.2015

    • Author(s)
      Naoki Iwanaga, Shigeki Nakamura, Kazuhiro Oshima, Toshiki Kajihara, Takahiro Takazono, Taiga Miyazaki, Koichi Izumikawa, Katsunori Yanagihara, Akihiro Sugawara, Toshiaki Sunazuka, Satoshi Omura and Shigeru Kohno
    • Journal Title

      J. Infect. Dis.

      Volume: - Issue: 7 Pages: 1150-1159

    • DOI

      10.1093/infdis/jiv157

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 臨床に役立つ深在性真菌症研究の最前線2019

    • Author(s)
      宮崎泰可
    • Organizer
      第6回 日本医真菌学会関西支部「深在性真菌症研究会」
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 病原酵母カンジダにおけるストレス応答機序解明の魅力2018

    • Author(s)
      宮崎泰可
    • Organizer
      第22回 酵母合同シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Translational research on invasive candidiasis2018

    • Author(s)
      Taiga Miyazaki
    • Organizer
      7th Global Network Forum on Infection and Immunity
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 侵襲性カンジダ症に関する最新の話題2018

    • Author(s)
      宮崎泰可
    • Organizer
      第29回 日本臨床微生物学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 真菌症検査の現状と課題2017

    • Author(s)
      宮崎泰可
    • Organizer
      日本臨床微生物学会
    • Place of Presentation
      長崎県医師会館(長崎県・長崎市)
    • Year and Date
      2017-01-21
    • Related Report
      2016 Research-status Report
  • [Presentation] カンジダの抗真菌薬耐性2017

    • Author(s)
      宮崎泰可
    • Organizer
      第91回日本感染症学会総会・学術講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] 抗真菌薬の適正使用を考える2017

    • Author(s)
      宮崎泰可
    • Organizer
      第61回日本医真菌学会総会・学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] カンジダ症 診断と治療の最新動向2016

    • Author(s)
      宮崎泰可
    • Organizer
      第60回日本医真菌学会総会
    • Place of Presentation
      東京都立産業貿易センター台東館(東京都・台東区)
    • Year and Date
      2016-10-01
    • Related Report
      2016 Research-status Report
  • [Presentation] フルコナゾール2016

    • Author(s)
      宮崎泰可
    • Organizer
      第3回日本医真菌学会関西支部会
    • Place of Presentation
      TKPガーデンシティPREMIUM大阪駅前(大阪府・大阪市)
    • Year and Date
      2016-09-10
    • Related Report
      2016 Research-status Report
  • [Presentation] カンジダ研究の軌跡と今後の展望2016

    • Author(s)
      宮崎泰可
    • Organizer
      第90回日本感染症学会総会
    • Place of Presentation
      仙台国際センター(宮城県・仙台市)
    • Year and Date
      2016-04-15
    • Related Report
      2016 Research-status Report
  • [Presentation] 慢性肺アスペルギルス症2015

    • Author(s)
      宮崎泰可
    • Organizer
      第59回日本医真菌学会総会
    • Place of Presentation
      ホテルさっぽろ芸文館(北海道・札幌市)
    • Year and Date
      2015-10-10
    • Related Report
      2015 Research-status Report
  • [Presentation] 病原真菌における小胞体ストレス応答と抗真菌薬耐性の関連2015

    • Author(s)
      宮崎泰可、中山浩伸、峰松明日香、山内俊輔、西川 博、田代将人、髙園貴弘、小佐井康介、森永芳智、島村真太郎、中村茂樹、栗原慎太郎、塚本美鈴、泉川公一、柳原克紀、河野 茂.
    • Organizer
      第63回日本化学療法学会総会
    • Place of Presentation
      京王プラザホテル(東京都・新宿)
    • Year and Date
      2015-06-05
    • Related Report
      2015 Research-status Report
  • [Presentation] Roles of vacuolar H+-ATPase in the oxidative stress response in Candida glabrata2015

    • Author(s)
      Hiroshi Nishikawa, Taiga Miyazaki
    • Organizer
      19th ISHAM
    • Place of Presentation
      メルボルン(オーストラリア)
    • Year and Date
      2015-05-06
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 変貌する真菌症とその対策―治療薬開発の現状―2015

    • Author(s)
      宮崎泰可
    • Organizer
      第89回日本感染症学会総会
    • Place of Presentation
      国立京都国際会館(京都府・京都市)
    • Year and Date
      2015-04-16
    • Related Report
      2015 Research-status Report
  • [Presentation] 深在性真菌症の診療―ガイドラインと最新のエビデンスを踏まえて―2015

    • Author(s)
      宮崎泰可
    • Organizer
      第89回日本感染症学会総会
    • Place of Presentation
      国立京都国際会館(京都府・京都市)
    • Year and Date
      2015-04-16
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2020-03-30  

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