Development of novel therapeutic strategies to overcome refractory fungal infections
| Project/Area Number |
15K09573
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Nagasaki University |
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Principal Investigator |
MIYAZAKI Taiga 長崎大学, 医歯薬学総合研究科(医学系), 講師 (60448496)
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 抗真菌薬 / 抗真菌薬耐性 |
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| Outline of Final Research Achievements |
In the context of limited availability of antifungal agents, the emergence of multidrug resistant isolates has become a critical issue in clinical settings, underscoring an urgent need for the development of new antifungal strategies.
In this study, we have elucidated the resistant mechanisms of multidrug resistant Candida glabrata and the clinical and microbiological characteristics of Candida guilliermondii infections. In addition, we performed high-throughput screening of chemical compound libraries and found a novel compound that had potent antifungal activities.
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| Academic Significance and Societal Importance of the Research Achievements |
侵襲性真菌感染症は致死的な経過をとることも少なくない。治療薬が少ないなかで耐性菌の出現が問題となっている。今回、耐性化のメカニズムや耐性菌感染症の臨床的および微生物学的特徴を一部解明した。また、化合物ライブラリーのスクリーニングにより、病原真菌に有効な新規化合物を同定することができた。これらの研究成果は、今後の新薬開発に寄与するものと考える。
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Report
(5 results)
Research Products
(22 results)
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[Journal Article] T-2307, a novel arylamidine, is transported into Candida albicans by a high-affinity spermine and spermidine carrier regulated by Agp2.2016
Author(s)
Nishikawa H, Sakagami T, Yamada E, Fukuda Y, Hayakawa H, Nomura N, Mitsuyama J, Miyazaki T, Mukae H, Kohno S.
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Journal Title
J Antimicrob Chemother.
Volume: 印刷中
Related Report
Peer Reviewed
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[Journal Article] The risk factors for developing of chronic pulmonary aspergillosis in nontuberculous mycobacteria patients and clinical characteristics and outcomes in chronic pulmonary aspergillosis patients coinfected with nontuberculous mycobacteria.2016
Author(s)
Takeda K, Imamura Y, Takazono T, Yoshida M, Ide S, Hirano K, Tashiro M, Saijo T, Kosai K, Morinaga Y, Nakamura S, Kurihara S, Tsukamoto M, Miyazaki T, Tashiro T, Kohno S, Yanagihara K, Izumikawa K.
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Journal Title
Med Mycol.
Volume: 54
Issue: 2
Pages: 120-127
DOI
Related Report
Peer Reviewed
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[Journal Article] Toll-like Receptor 4 Agonistic Antibody Promotes Host Defense against Chronic Pseudomonas aeruginosa Lung Infection in Mice.2016
Author(s)
Nakamura S, Iwanaga N, Seki M, Fukudome K, Oshima K, Miyazaki T, Izumikawa K, Yanagihara K, Miyazaki Y, Mukae H, Kohno S.
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Journal Title
Infect Immun.
Volume: 印刷中
Related Report
Peer Reviewed
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[Journal Article] Macrolides promote CCL2-mediated macrophage recruitment and clearance of nasopharyngeal pneumococcal colonies in mice.2015
Author(s)
Naoki Iwanaga, Shigeki Nakamura, Kazuhiro Oshima, Toshiki Kajihara, Takahiro Takazono, Taiga Miyazaki, Koichi Izumikawa, Katsunori Yanagihara, Akihiro Sugawara, Toshiaki Sunazuka, Satoshi Omura and Shigeru Kohno
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Journal Title
J. Infect. Dis.
Volume: -
Issue: 7
Pages: 1150-1159
DOI
Related Report
Peer Reviewed / Open Access
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