| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
The purpose of this study was to clarify the mechanism of avian influenza viruses to infect human airway epithelial cells, from aspects of both the virus genome and host cells. Viral infectivity in human airway epithelial cell clones was different between currently circulating avian influenza virus isolated from humans and the virus from birds. This distinct infectivity was determined by the specific amino acid sequences, located in individual genomes of the viruses from human and birds. Next, we assessed the infectivity of avian influenza viruses in differentiated human airway epithelial cell clones. The difference in viral infectivity in differentiated human airway epithelial cell clones may be associated with the difference in cell differentiation.
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