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Analyses of pathological conditions, pathogenic molecular epidemiology, and antimicrobial resistance in uterine infections due to group A streptococcus

Research Project

Project/Area Number 15K09578
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Infectious disease medicine
Research InstitutionKitasato University

Principal Investigator

Takahashi Takashi  北里大学, 感染制御科学府, 教授 (00292855)

Co-Investigator(Renkei-kenkyūsha) YOSHIDA Haruno  北里大学, 大学院感染制御科学府, 助手 (70563386)
MATSUI Hidenori  北里大学, 大学院感染制御科学府, 講師 (30219373)
ARAI Kazuaki  北里大学, 北里生命科学研究所, 研究員 (30547386)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords細菌 / 子宮内感染症 / 菌側因子 / 宿主因子 / 薬剤耐性 / 分子疫学 / 薬物耐性
Outline of Final Research Achievements

We selected vaginal discharge-origin isolates of pathogenic group A beta-hemolytic streptococcus, the throat swab-derived strains, and the isolates from severe infectious diseases using the established databases including bacterial information and patient backgrounds, which were collected nationwide. As compared with the microbiological features in the throat-origin isolates, there were significantly characteristic findings in the vagina-derived strains. In addition, we could observe similarities between the microbiological features in the vagina-origin isolates and those in the strains from uterine infections.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (11 results)

All 2018 2017 2016 2015 Other

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (4 results) (of which Int'l Joint Research: 2 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Pleural empyema and streptococcal toxic shock syndrome due to Streptococcus pyogenes in a healthy Spanish traveler in Japan2017

    • Author(s)
      Tetsuya Sakai, Daisuke Taniyama, Takashi Takahashi, et al.
    • Journal Title

      IDCases

      Volume: 9 Pages: 85-88

    • DOI

      10.1016/j.idcr.2017.06.006

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case of descending mediastinitis caused by Streptococcus pyogenes harboring genotype emm 25 and sequence type 6602017

    • Author(s)
      Hiroaki Ohya, Nobuaki Mori, Takashi Takahashi, et al.
    • Journal Title

      J Infect Chemother

      Volume: 23 Issue: 6 Pages: 403-406

    • DOI

      10.1016/j.jiac.2016.12.018

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characteristics of mucoid Streptococcus pyogenes isolates from two patients with pneumonia in a local community2016

    • Author(s)
      Nobuaki Mori, Sakiko Hosoo, Takashi Takahashi, et al.
    • Journal Title

      IDCases

      Volume: 6 Pages: 43-46

    • DOI

      10.1016/j.idcr.2016.09.002

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epidemiological study of erythromycin-resistant Streptococcus pyogenes from Korea and Japan by emm genotyping and multilocus sequence typing2016

    • Author(s)
      Takashi Takahashi, Kazuaki Arai, Haruno Yoshida, et al.
    • Journal Title

      Ann Lab Med

      Volume: 36 Issue: 1 Pages: 9-14

    • DOI

      10.3343/alm.2016.36.1.9

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 化膿レンサ球菌による子宮内感染症2015

    • Author(s)
      高橋 孝、吉田春乃
    • Journal Title

      Medical Practice

      Volume: 32 Pages: 1714-1714

    • Related Report
      2015 Research-status Report
  • [Presentation] Exotoxin profiles of Streptococcus pyogenes isolates from vaginal discharges as compared to those from throat swabs in Japan2018

    • Author(s)
      Takashi Takahashi
    • Organizer
      第29回日本臨床微生物学会総会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Genome Profiling (GP)法を用いたムコイド型化膿レンサ球菌流行株の識別2017

    • Author(s)
      高橋 孝、森 伸晃
    • Organizer
      第91回日本感染症学会学術講演会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2017-04-06
    • Related Report
      2016 Research-status Report
  • [Presentation] Epidemiological characteristics of Streptococcus pyogenes isolated from vaginal discharges in 2014, Japan: differences with respect to those obtained in 20122017

    • Author(s)
      Takashi Takahashi, Kazuaki Arai, Miho Ogawa, et al.
    • Organizer
      20th General Meeting of Korean Society of Clinical Microbioogy
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Epidemiological characteristics of Streptococcus pyogenes isolated from vaginal discharges as compared with those from throat swabs in Japan2015

    • Author(s)
      Takashi Takahashi, Kazuaki Arai, Haruno Yoshida, et al.
    • Organizer
      14th East Asian Conference on Infection Control and Prevention
    • Place of Presentation
      アクロス福岡(福岡県福岡市)
    • Year and Date
      2015-11-12
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Book] 感染症の診断って、こんなちょっとしたことで差がついちゃうんですね:遺伝子検査(分担項目)2017

    • Author(s)
      高橋 孝(分担執筆)
    • Publisher
      南江堂
    • Related Report
      2016 Research-status Report
  • [Remarks] 北里大学大学院感染制御科学府・感染症学研究室・研究の概要

    • URL

      https://www.kitasato-u.ac.jp/lisci/life/chart/LSI-lab15.html

    • Related Report
      2017 Annual Research Report 2016 Research-status Report 2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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