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Elucidation and clinical application of stringent response controlling an MRSA infectious disease

Research Project

Project/Area Number 15K09581
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Infectious disease medicine
Research InstitutionJuntendo University

Principal Investigator

KATAYAMA YUKI  順天堂大学, 医学部, 助教 (60365591)

Research Collaborator AZECHI takuya  
ASAKURA kouta  
SASANO hiroshi  
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
KeywordsMRSA / Vancomycin / slow-VISA / stringent response / Infectious Disease / rpoB / staphylococcus / 薬剤耐性 / 難治感染症 / バンコマイシン / VISA / 緊縮応答 / 薬剤耐性菌 / rpoB 遺伝子 / ppGpp / 難治性感染症 / 院内感染 / 抗MRSA薬
Outline of Final Research Achievements

The slow-vancomycin-intermediate Staphylococcus aureus (VISA) strains can be difficult to detect because prolonged incubation is required and the phenotype is unstable. We found that mupirocin induced stable expression of vancomycin resistance. On the basis of these results, we developed a method for detection of slow-VISA using by mupirocin 0.032 ug/ml (Patent Application No. PCT/JP2017/008975filed on March 7, 2017). Using this method, we detected 53 (15.6%) slow-VISA isolates among clinical MRSA isolates. In contrast, the VISA phenotype was detected in fewer than 1% of isolates. Moreover, we revealed that slow-VISA strains survive in small numbers among hVISA isolates according to deep-sequencing analysis, and when the cells are incubated again in the presence of vancomycin. The existence of this slow-VISA parent population may result in a recurrent MRSA infection. These findings may account in part for the recurrence and persistence of slow-VISA in MRSA infection.

Academic Significance and Societal Importance of the Research Achievements

Antimicrobial Resistance;AMRによる死亡者数は2050年にガンによる死亡者数を越えると想定されている (G7 OECD report,2015)。そこでWHOや主要国首脳会議から抗菌薬使用制限が提言され、本邦も2020年までに「数十%の抗菌薬耐性菌の減少」の成果指標を設定した(感染症対策閣僚会議, 2016)。特に本邦におけるMRSAのヒトにおける検出の割合は、他国と比較して高い(WHO 2014)。本研究では、新規高度薬剤耐性の国際基準を確立し、耐性化機構の解明、検出方法、実用化に向けた治療戦略の臨床開発を遂行し AMRアクションプランの成果指標に貢献した。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (60 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (3 results) Journal Article (9 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 8 results,  Open Access: 8 results,  Acknowledgement Compliant: 5 results) Presentation (41 results) (of which Int'l Joint Research: 6 results,  Invited: 10 results) Remarks (4 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 2 results)

  • [Int'l Joint Research] University of California San Francisco(米国)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] University of California San Francisco(米国)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] University of California San Francisco(米国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Rapid and easy detection of low-level resistance to vancomycin in methicillin-resistant Staphylococcus aureus by matrix-assisted laser desorption ionization time-of-flight mass spectrometry.2018

    • Author(s)
      Asakura K, Azechi T, Sasano H, Matsui H, Hanaki H, Miyazaki M, Takata T, Sekine M, Takaku T, Ochiai T, Komatsu N, Shibayama K, Katayama Y, Yahara K.
    • Journal Title

      PLoS One.

      Volume: 13(3) Issue: 3 Pages: e0194212-e0194212

    • DOI

      10.1371/journal.pone.0194212

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prevalence of Slow-Growth Vancomycin Nonsusceptibility in Methicillin-Resistant Staphylococcus aureus2017

    • Author(s)
      Katayama Yuki、Azechi Takuya、Miyazaki Motoyasu、Takata Tohru、Sekine Miwa、Matsui Hidehito、Hanaki Hideaki、Yahara Koji、Sasano Hiroshi、Asakura Kota、Takaku Tomoiku、Ochiai Tomonori、Komatsu Norio、Chambers Henry F.
    • Journal Title

      Antimicrobial Agents and Chemotherapy

      Volume: 61 Issue: 11

    • DOI

      10.1128/aac.00452-17

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 抗菌薬耐性菌の出現と蔓延を抑制する微生物診断法の臨床開発2017

    • Author(s)
      片山由紀
    • Journal Title

      実験医学

      Volume: 11 Pages: 3106-3106

    • Related Report
      2017 Research-status Report
    • Open Access
  • [Journal Article] Why Won’t the Intractable MRSA Infections Go Away?2016

    • Author(s)
      片山 由紀
    • Journal Title

      生化学

      Volume: 88 Issue: 3 Pages: 386-390

    • DOI

      10.14952/SEIKAGAKU.2016.880386

    • ISSN
      0037-1017
    • Year and Date
      2016-06-25
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Complete Genome Sequence of a Vancomycin-Intermediate Staphylococcus aureus Strain MI (HIP5827),2016

    • Author(s)
      Tomomi Hishinuma, Yuki Katayama*, Miki Matsuo, Takashi Sasaki, and Keiichi Hiramatsu.
    • Journal Title

      Genome Announcements

      Volume: April,4 Issue: 2

    • DOI

      10.1128/genomea.00123-16

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Complete reconstitution of the VISA phenotype of Mu50 in Vancomycin-Susceptible Staphylococcus aureus.2016

    • Author(s)
      Yuki Kayayama*, Miwa Sekine, Tomomi Hishinuma, Yoshifumi Aiba and Keiichi Hiramatsu
    • Journal Title

      Antimicrobial Agents and Chemotherapy

      Volume: 60 Issue: 6 Pages: 3730-3743

    • DOI

      10.1128/aac.00420-16

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] バンコマイシン中間耐性MRSA (VISA)の耐性機構と復帰抗生物質.2016

    • Author(s)
      平松啓一、森本ゆふ、馬場理、佐々木崇、菱沼知美、片山由紀、松尾美記、桑原京子、上原由紀、五十嵐雅之
    • Journal Title

      Japanese Journal of Chemotherapy

      Volume: 64 Pages: 503-512

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 難治性MRSA感染症はなぜ再燃するのか2016

    • Author(s)
      片山 由紀
    • Journal Title

      日本生化学会雑誌

      Volume: 88-3

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A mutation of RNA polymerase beta subunit (RpoC) converts heterogeneously vancomycin-intermediate S. aureus (hVISA) into ‘slow-VISA’ (sVISA)2015

    • Author(s)
      Miki Matsuo, Tomomi Hishinuma, Yuki Katayama, and Keiichi Hiramatsu
    • Journal Title

      Antimicrobial Agents and Chemotherapy.

      Volume: 59 Issue: 7 Pages: 4215-4225

    • DOI

      10.1128/aac.00135-15

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 血液培養液由来slow-growth vancomycin non-susceptible S.aureusの バンコマイシン耐性化機構について2018

    • Author(s)
      片山由紀、畦地拓哉、宮崎元康、矢原耕史、鈴木仁人、仲村佳彦、松井秀仁、朝倉 、笹野央、高田徹、柴山恵吾、花木秀明
    • Organizer
      MRSAフォーラム2018
    • Related Report
      2018 Annual Research Report 2017 Research-status Report
  • [Presentation] ダプトマイシン治療後に再燃したslow-VISA感染症の解析2018

    • Author(s)
      畦地拓哉、片山由紀、宮崎元康、矢原耕史、鈴木仁人、松井秀仁、岡村圭祐、仲村佳彦、小宮ゆきえ、浦田秀則、笹野央、朝倉弘太、山口 哲央、柴山恵吾、花木秀明、高田徹
    • Organizer
      MRSAフォーラム2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] ダプトマイシン治療後に再燃したslow-VISA感染症の解析2018

    • Author(s)
      畦地拓哉、片山由紀、宮崎元康、矢原耕史、鈴木仁人、松井秀仁、岡村圭祐、仲村佳彦、小宮ゆきえ、浦田秀則、笹野央、朝倉弘太、山口哲央、柴山恵吾、花木秀明、高田徹
    • Organizer
      MRSAフォーラム2018
    • Related Report
      2017 Research-status Report
  • [Presentation] MRSA感染症再燃患者血液培養液から初めて分離されたslow-VISA(Vancomycin-Intermediate Staphylococcus aureus)の解析。2017

    • Author(s)
      畦地拓哉、片山由紀、宮崎元康、矢原耕史、鈴木仁人、笹野央、朝倉弘太、高田徹
    • Organizer
      第65回日本化学療法学会総会。
    • Place of Presentation
      京王プラザホテル (東京都新宿区)
    • Year and Date
      2017-04-06
    • Related Report
      2016 Research-status Report
  • [Presentation] 骨・関節のMRSA再燃感染症から検出されたslow-VISA。2017

    • Author(s)
      笹野央、片山由紀、内山勝文、畦地拓哉、朝倉弘太、鈴木仁人、矢原耕史、松井秀人、花木秀明
    • Organizer
      第91回日本感染症学会総会。
    • Place of Presentation
      京王プラザホテル (東京都新宿区)
    • Year and Date
      2017-04-06
    • Related Report
      2016 Research-status Report
  • [Presentation] The mechanism of resistance to vancomycin in slow-growth VISA possibly responsible for recurrent MRSA infection.2017

    • Author(s)
      Yuki Katayama
    • Organizer
      Clinicalmicrobiology 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] MAIDI-TOF MSデータを用いたバンコマイシン低感受性 MRSA株の自動判別2017

    • Author(s)
      朝倉弘太、片山由紀、畦地拓哉、宮崎元康、笹野央、松井秀仁、高田徹、花木秀明、矢原耕史。
    • Organizer
      MRSAフォーラム2017
    • Related Report
      2017 Research-status Report
  • [Presentation] 骨・関節のMRSA再燃感染症から検出されたslow-VISA2017

    • Author(s)
      笹野央、片山由紀、内山勝文、矢原耕史、鈴木仁人、畦地拓哉、朝倉弘太、松井秀仁、柴山恵吾、花木秀明
    • Organizer
      MRSAフォーラム2017
    • Related Report
      2017 Research-status Report
  • [Presentation] MRSA再燃感染症の血液培養液から分離されたslow-VISAの解析2017

    • Author(s)
      片山由紀、畦地拓哉、笹野央、宮崎元康、岡村圭祐、矢原耕史、鈴木仁人、小宮ゆきえ、朝倉弘太、浦田秀則、柴山 恵吾、高田徹
    • Organizer
      MRSAフォーラム2017
    • Related Report
      2017 Research-status Report
  • [Presentation] 血液培養液由来MRSA 株におけるslow-growth vancomycin non-susceptible S.aureusの全国疫学調査と バンコマイシン耐性化機構の検討2017

    • Author(s)
      片山由紀、畦地拓哉、宮崎元康、矢原耕史、鈴木仁人、仲村佳彦、関根美和、笹野央、朝倉弘太、松井秀仁、高田徹、柴山恵吾、花木秀明
    • Organizer
      MRSAフォーラム2017
    • Related Report
      2017 Research-status Report
  • [Presentation] MAIDI-TOF-MSデータを用いたバンコマイシン低感受性 MRSA株の自動判別。2017

    • Author(s)
      朝倉弘太、片山由紀、畦地拓哉、笹野央、松井秀仁、花木秀明、矢原耕史。
    • Organizer
      第65回日本化学療法学会総会。
    • Related Report
      2017 Research-status Report 2016 Research-status Report
  • [Presentation] 骨・関節のMRSA再燃感染症から検出されたslow-VISA。2017

    • Author(s)
      笹野央、片山由紀、内山勝文、畦地拓哉、朝倉弘太、鈴木仁人、矢原耕史、松井秀人、花木秀明
    • Organizer
      第91回日本感染症学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] MRSA感染症再燃患者血液培養液から初めて分離されたslow-VISA(Vancomycin-Intermediate Staphylococcus aureus)の解析。2017

    • Author(s)
      畦地拓哉、片山由紀、宮崎元康、矢原耕史、鈴木仁人、笹野央、朝倉弘太、高田徹。
    • Organizer
      第65回日本化学療法学会総会。
    • Related Report
      2017 Research-status Report
  • [Presentation] 骨・関節のMRSA再燃感染症から検出されたslow-VISA。2017

    • Author(s)
      ○笹野央、片山由紀、内山勝文、矢原耕史、鈴木仁人、畦地拓哉、朝倉弘太、松井秀仁、柴山恵吾、花木秀明。
    • Organizer
      MRSAフォーラム2017
    • Place of Presentation
      京王プラザホテル (東京都新宿区)
    • Related Report
      2016 Research-status Report
  • [Presentation] 「MAIDI-TOF MSデータを用いたバンコマイシン低感受性 MRSA株の自動判別」2017

    • Author(s)
      朝倉弘太、片山由紀、畦地拓哉、宮崎元康、笹野央、松井秀仁、高田徹、花木秀明、矢原耕史。
    • Organizer
      MRSAフォーラム2017
    • Place of Presentation
      京王プラザホテル (東京都新宿区)
    • Related Report
      2016 Research-status Report
  • [Presentation] MRSA再燃感染症の血液培養液から分離されたslow-VISAの解析。2017

    • Author(s)
      畦地拓哉、片山由紀、宮崎元康、岡村圭祐、矢原耕史、鈴木仁人、小宮ゆきえ、笹野央、朝倉弘太、浦田秀則、柴山 恵吾、高田徹。
    • Organizer
      MRSAフォーラム2017
    • Place of Presentation
      京王プラザホテル (東京都新宿区)
    • Related Report
      2016 Research-status Report
  • [Presentation] 血液培養液由来MRSA 株におけるslow-growth vancomycin non-susceptible S.aureusの全国疫学調査と バンコマイシン耐性化機構の検討。2017

    • Author(s)
      ○片山由紀、畦地拓哉、宮崎元康、矢原耕史、鈴木仁人、仲村佳彦、関根美和、笹野央、朝倉弘太、松井秀仁、高田徹、柴山恵吾、花木秀明。
    • Organizer
      MRSAフォーラム2017
    • Place of Presentation
      京王プラザホテル (東京都新宿区)
    • Related Report
      2016 Research-status Report
  • [Presentation] 難治性MRSA 感染症の克服2016

    • Author(s)
      ○Yuki Katayama
    • Organizer
      第17回Pharmaco-Hematology シンポジウム
    • Place of Presentation
      帝京大学 板橋キャンパス(東京都板橋区)
    • Year and Date
      2016-09-03
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Potential Pitfall in Vancomycin Therapy against MRSA infection by slow-VISA2016

    • Author(s)
      Yuki Katayama
    • Organizer
      17th ISSSI (International Symposium on Staphylococci and Staphylococcal Infection)
    • Place of Presentation
      Soul, Korea
    • Year and Date
      2016-08-30
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Potential Pitfall in Vancomycin Therapy against MRSA infection by slow-VISA2016

    • Author(s)
      ○Yuki Katayama
    • Organizer
      17th ISSSI (International Symposium on Staphylococci and Staphylococcal Infection),
    • Place of Presentation
      Nine Tree Convention Gwanghwamun (Soul, Korea)
    • Year and Date
      2016-08-30
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] MRSA感染症の再燃と致死性の関与が推測される新規表現型のMRSA “slow-VISA”の検出2016

    • Author(s)
      ○片山由紀、畦地拓哉、宮崎元康、高田徹、相羽由詞、関根美和、花木秀明
    • Organizer
      MRSAフォーラム2016
    • Place of Presentation
      岐阜市文化産業交流センター(岐阜県岐阜市)
    • Year and Date
      2016-07-23
    • Related Report
      2015 Research-status Report
  • [Presentation] Detection of high-level resistance to vancomycin ‘slow VISA’ among clinical isolates2016

    • Author(s)
      ○Yuki Katayama
    • Organizer
      University of California San Francisco (UCSF), Division of Infectious Diseases meeting
    • Place of Presentation
      University of California San Francisco, (San Francisco, CA, US)
    • Year and Date
      2016-06-21
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] The Mechanism of Resistance to Vancomycin in slow-VISA Possibly Responsible for Recurrent MRSA Infection2016

    • Author(s)
      Yuki Katayama
    • Organizer
      ASM Microb and ICAAC 2016
    • Place of Presentation
      Boston, MA, US
    • Year and Date
      2016-06-16
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] The Mechanism of Resistance to Vancomycin in slow-VISA Possibly Responsible for Recurrent MRSA Infection2016

    • Author(s)
      ○Yuki Katayama, Yoshifumi Aiba, Miwa Sekine, Motoyasu Miyazaki, Tohru Takata, Miki Matsuo, Takuya Azechi, Tomomi Hishinuma, Hideaki Hanaki, and Keiichi Hiramatsu
    • Organizer
      ASM Microb and ICAAC 2016
    • Place of Presentation
      Boston Convention and Exhibition Center (Boston, MA, US)
    • Year and Date
      2016-06-16
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] MRSA感染症再燃の関与が推測されるslow-VISAの臨床分離株からの検出。2016

    • Author(s)
      畦地拓哉、片山由紀、松尾美記、宮崎元康、高田徹、相羽由詞、花木秀明。
    • Organizer
      第64回日本化学療法学会総会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県神戸市)
    • Year and Date
      2016-06-09
    • Related Report
      2016 Research-status Report
  • [Presentation] メチシリン耐性黄色ブドウ球菌(MRSA)におけるβラクタム薬高度耐性に関与する因子の網羅的同定2016

    • Author(s)
      松尾美記、相羽由詞、片山由紀、平松啓一
    • Organizer
      第64回日本化学療法学会総会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県神戸市)
    • Year and Date
      2016-06-09
    • Related Report
      2016 Research-status Report
  • [Presentation] The Mechanism of Resistance to Vancomycin in ‘slow-VISA Possibly Responsible for Recurrent MRSA Infection。2016

    • Author(s)
      片山由紀、相羽由詞、関根美和、松尾美記、菱沼知美、平松啓一
    • Organizer
      第64回日本化学療法学会総会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県神戸市)
    • Year and Date
      2016-06-09
    • Related Report
      2016 Research-status Report
  • [Presentation] The Mechanism of Resistance to Vancomycin in ‘slow-VISA Possibly Responsible for Recurrent MRSA Infection2016

    • Author(s)
      ○片山由紀、相羽由詞、関根美和、松尾美記、菱沼知美、平松啓一
    • Organizer
      第64回日本化学療法学会総会
    • Place of Presentation
      神戸ポートビアホテル(兵庫県神戸市)
    • Year and Date
      2016-06-09
    • Related Report
      2015 Research-status Report
  • [Presentation] MRSA感染症再燃の関与が推測されるslow-VISAの臨床分離株からの検出2016

    • Author(s)
      ○畦地拓哉、片山由紀、松尾美記、宮崎元康、高田徹、相羽由詞、花木秀明
    • Organizer
      第64回日本化学療法学会総会
    • Place of Presentation
      神戸ポートビアホテル(兵庫県神戸市)
    • Year and Date
      2016-06-09
    • Related Report
      2015 Research-status Report
  • [Presentation] メチシリン耐性黄色ブドウ球菌(MRSA)におけるβラクタム薬高度耐性に関与する因子の網羅的同定2016

    • Author(s)
      ○松尾美記、相羽由詞、片山由紀、平松啓一
    • Organizer
      第64回日本化学療法学会総会
    • Place of Presentation
      神戸ポートビアホテル(兵庫県神戸市)
    • Year and Date
      2016-06-09
    • Related Report
      2015 Research-status Report
  • [Presentation] 臨床分離株における難治性MRSA感染症再燃に寄与するslow-VISA(バンコマイシン中間耐性黄色ブドウ球菌)の検出。2016

    • Author(s)
      畦地拓哉、○片山由紀、松尾 美記、高田 徹、花木秀明
    • Organizer
      第90 回日本感染症学会総会・学術講演会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-04-15
    • Related Report
      2016 Research-status Report
  • [Presentation] 臨床分離株における難治性MRSA感染症再燃に寄与するslow-VISA(バンコマイシン中間耐性黄色ブドウ球菌)の検出2016

    • Author(s)
      畦地拓哉、○片山 由紀、松尾 美記、高田 徹、花木秀明
    • Organizer
      第90 回日本感染症学会総会・学術講演会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-04-15
    • Related Report
      2015 Research-status Report
  • [Presentation] The Mechanism of Resistance to Vancomycin in ‘slow-VISA’ possibly responsible for Recurrent MRSA Infection.2016

    • Author(s)
      ○Yuki Katayama, Takuya Azechi, Motoyasu Miyazaki, Thoru Takada, Yoshifumi Aiba, Tomomi Hishinuma Miki Matsuo、Hideaki Hanaki. and Keiichi Hiramatsu.
    • Organizer
      第89回日本細菌学会総会
    • Place of Presentation
      大阪国際交流センター(大阪府大阪市)
    • Year and Date
      2016-03-23
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 難治性MRSA 感染症の克服2016

    • Author(s)
      Yuki Katayama
    • Organizer
      第17回Pharmaco-Hematology シンポジウム
    • Place of Presentation
      帝京大学 板橋キャンパス 東京
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] MRSA感染症の再燃と致死性の関与が推測される新規表現型のMRSA “slow-VISA”の検出。2016

    • Author(s)
      片山由紀、畦地拓哉、宮崎元康、高田徹、相羽由詞、関根美和、花木秀明。
    • Organizer
      MRSAフォーラム2016。
    • Place of Presentation
      岐阜市文化産業交流センター(岐阜県岐阜市)
    • Related Report
      2016 Research-status Report
  • [Presentation] A mutation of RNA polymerase β´ subunit (RpoC) converts heterogeneously vancomycin intermediate Staphylococcus aureus (hVISA) into “slow-VISA” (sVISA)2015

    • Author(s)
      ○松尾美記、菱沼知美、片山由紀、平松啓一
    • Organizer
      第38回日本分子生物学会、第88回日本生化学大会、合同大会
    • Place of Presentation
      神戸ポートビアホテル(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] 新規VISA表現型slow-VISA による難治性MRSA感染症の再燃について2015

    • Author(s)
      ○Yuki Katayama, Tomomi Hishinuma, Miki Matsuo, Yoshifumi Aiba, Takashi Sasaki, Miwa Sekine and Keiichi Hiramatsu.
    • Organizer
      第98回日本細菌学会関東支部総会
    • Place of Presentation
      東京歯科大学血脇ホール(東京都千代田区)
    • Year and Date
      2015-10-29
    • Related Report
      2015 Research-status Report
  • [Presentation] 難治性MRSA感染症の再燃に関与しているslow-VISA(バンコマイシン中間耐性黄色ブドウ球菌)について2015

    • Author(s)
      ○Yuki Katayama, Tomomi Hishinuma, Miki Matsuo, Yoshifumi Aiba, Miwa Sekine, Takashi Sasaki, and Keiichi Hiramatsu
    • Organizer
      第62回日本化学療法学会東日本支部総会
    • Place of Presentation
      ロイトン札幌(北海道札幌市)
    • Year and Date
      2015-10-21
    • Related Report
      2015 Research-status Report
  • [Presentation] 難治性MRSA 感染症の克服2015

    • Author(s)
      ○片山由紀
    • Organizer
      第60回ブドウ球菌研究会
    • Place of Presentation
      広島大学東京オフィス(東京港区)
    • Year and Date
      2015-09-19
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 難治MRSA感染症の再燃と薬剤耐性化のメカニズムについて2015

    • Author(s)
      ○片山由紀
    • Organizer
      福岡大学 医学部 腫瘍血液感染症内科主催セミナー
    • Place of Presentation
      福岡大学医学部 (福岡県福岡市)
    • Year and Date
      2015-08-18
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] なぜ難治性MRSA感染症は再燃するのか2015

    • Author(s)
      ○Yuki Katayama, Tomomi Hishinuma, Yoshifumi Aiba, Takashi Sasaki, Miwa Sekine, Takashi Sasaki, Miki Matsuo and Keiichi Hiramatsu
    • Organizer
      第16回Pharmaco-Hematology シンポジウム
    • Place of Presentation
      日本薬学会長い記念ホール(東京都渋谷区)
    • Year and Date
      2015-05-13
    • Related Report
      2015 Research-status Report
  • [Remarks] 順天堂大学 研究者データベース

    • URL

      http://www.juntendo.ac.jp/graduate/kenkyudb/search/researcher.php?MID=784

    • Related Report
      2017 Research-status Report
  • [Remarks] Research map

    • URL

      https://researchmap.jp/read0162215/

    • Related Report
      2017 Research-status Report
  • [Remarks] 学校法人 順天堂 研究者情報データベース

    • URL

      http://www.juntendo.ac.jp/graduate/kenkyudb/search/researcher.php?MID=784

    • Related Report
      2016 Research-status Report
  • [Remarks] 順天堂大学 片山由紀

    • URL

      https://www.juntendo.ac.jp/graduate/kenkyudb/search/achievement.php?MID=784

    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] 特許権2017

    • Inventor(s)
      片山由紀
    • Industrial Property Rights Holder
      順天堂大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Acquisition Date
      2017
    • Related Report
      2017 Research-status Report
    • Overseas
  • [Patent(Industrial Property Rights)] slow-growth non-vancomycin susceptible Staphylococcs aureusの検出法2017

    • Inventor(s)
      Yuki Katayama
    • Industrial Property Rights Holder
      順天堂大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017-03-07
    • Related Report
      2016 Research-status Report
    • Overseas
  • [Patent(Industrial Property Rights)] slow-VISAの検出法2016

    • Inventor(s)
      片山由紀
    • Industrial Property Rights Holder
      片山由紀
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-046496
    • Filing Date
      2016-03-10
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2022-02-21  

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