Immunological activation and bone mineral loss in patients with HIV

• Project/Area Number: 15K09582
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Infectious disease medicine
• Research Institution: Teikyo University
• Principal Investigator: Ota Yasuo 帝京大学, 医学部, 教授 (80292936)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: HIV / 骨密度 / cART

Outline of Final Research Achievements

Clinical factors that were related to bone mineral density (BMD) loss in 31 HIV patients who started cART were studied. Tenofovir and protease inhibitors were related to BMD loss one year after initiation of cART. In addition, BMD loss decreased larger in HIV patients with lower CD4 T lymphocytes, suggesting that immunological activation might play some roles in BMD loss. However, LPS-induced monocyte activation was not associated with CD4 T lymphocytes counts. We need to take some measures that prevent from BMD loss especially in patients with low CD4 T lymphocytes counts.

Research Products

• [Journal Article] The Clinical Value of Cystatin C as a Marker of Renal Function in HIV Patients Receiving Dolutegravir. (2017)
  • Author(s): Yoshino Y, Koga I, Seo K, Kitazawa T, Ota Y.
  • Journal Title: AIDS Res Hum Retroviruses. Volume: 33(11) Pages: 1080-1082
  • Peer Reviewed
• [Journal Article] Decreased serum bone specific alkaline phosphatase and increased urinary N-terminal telopeptide of type I collagen as prognostic markers for bone mineral density loss in HIV patients on cART. (2016)
  • Author(s): Koga I, Seo K, Yoshino Y, Kitazawa T, Kurahashi I, Ota Y.
  • Journal Title: J Infect Chemother. Volume: 22 Issue: 8 Pages: 543-547
  • DOI: 10.1016/j.jiac.2016.05.005
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Increase of 25-hydroxyvitamin D levels after initiation of combination antiretroviral therapy (2015)
  • Author(s): Koga I, Seo K, Yoshino Y, Kitazawa T, Ota Y
  • Journal Title: J Infect Chemother Volume: 21 Issue: 10 Pages: 737-41
  • DOI: 10.1016/j.jiac.2015.07.003
  • Peer Reviewed / Open Access
• [Presentation] 未治療男性HIV患者における骨密度低下の状況及び治療開始後の変化 (2017)
  • Author(s): 吉野 友祐, 三須 恵太, 妹尾 和憲, 古賀 一郎, 北沢 貴利, 太田 康男
  • Organizer: 日本エイズ学会
• [Presentation] The clinical value of cystatin C as a marker of renal function in HIV patients receiving dolutegravir. (2017)
  • Author(s): Yusuke Yoshino, Keita Misu, Kazunori Seo, Ichiro Koga, Takatoshi Kitazawa, Yasuo Ota
  • Organizer: ID week 2017
  • Int'l Joint Research
• [Presentation] The prevalence of bone loss and short term effect of anti-retroviral therapy on bone mineral density in male Japanese naïve patients with HIV. (2017)
  • Author(s): Yusuke Yoshino, Keita Misu, Kazunori Seo, Ichiro Koga, Takatoshi Kitazawa, Yasuo Ota
  • Organizer: 30th International Congress of Chemotherapy and Infection
  • Int'l Joint Research
• [Presentation] 日本人HIV感染症患者におけるcART導入後の経過期間ごとの骨密度減少の推移 (2015)
  • Author(s): 古賀 一郎, 妹尾 和憲, 北沢 貴利, 太田 康男
  • Organizer: 第29回日本エイズ学会総会
  • Place of Presentation: 東京ドームホテル（東京都文京区）
  • Year and Date: 2015-11-30