Study the role of mucosal immunity of intestine in bacterial translocation
| Project/Area Number |
15K09584
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | バクテリアルトランスロケーション / 粘膜免疫 / 炎症性腸疾患 / NKT細胞 / バクテリアル・トランスロケーション |
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| Outline of Final Research Achievements |
Bacterial translocation (BT) is the phenomenon of invasion of indigenous intestinal bacteria through the gut mucosa to normally sterile tissues and the internal organs. The mucosal immune response in the intestine might play a role in BT. Therefore, the aim of this study was to evaluate the NKT cell in the relation to BT by using mouse model of inflammatory bowel disease (IBD). Mortality rate of CD1d knockout mice which lack NKT cells was significantly lower than that of control mice. Evaluation of the body weight changes and bloody stool score after the induction of IBD suggested that the more severe inflammation was shown in the wild type control mice. These results suggested that NKT cells may play a role in the progression of IBD.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Evolution and single-nucleotide polymorphisms in methicillin-resistant Staphylococcus aureus strains with reduced susceptibility to vancomycin and daptomycin, based on determination of the complete genome.2015
Author(s)
Yamaguchi T, Suzuki S, Okamura S, Miura Y, Tsukimori A, Nakamura I, Ito N, Masuya A, Shiina T, Matsumoto T.
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Journal Title
Antimicrob Agents Chemother.
Volume: 59
Issue: 6
Pages: 3585-3587
DOI
Related Report
Peer Reviewed
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