Study the role of mucosal immunity of intestine in bacterial translocation

• Project/Area Number: 15K09584
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Infectious disease medicine
• Research Institution: Tokyo Medical University
• Principal Investigator: Matsumoto Tetsuya 東京医科大学, 医学部, 主任教授 (10256688)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: バクテリアルトランスロケーション / 粘膜免疫 / 炎症性腸疾患 / NKT細胞 / バクテリアル・トランスロケーション

Outline of Final Research Achievements

Bacterial translocation (BT) is the phenomenon of invasion of indigenous intestinal bacteria through the gut mucosa to normally sterile tissues and the internal organs. The mucosal immune response in the intestine might play a role in BT. Therefore, the aim of this study was to evaluate the NKT cell in the relation to BT by using mouse model of inflammatory bowel disease (IBD). Mortality rate of CD1d knockout mice which lack NKT cells was significantly lower than that of control mice. Evaluation of the body weight changes and bloody stool score after the induction of IBD suggested that the more severe inflammation was shown in the wild type control mice. These results suggested that NKT cells may play a role in the progression of IBD.

Research Products

• [Journal Article] Epidemiological Trends Observed from Molecular Characterization of Methicillin-Resistant Staphylococcus aureus Isolates from Blood Cultures at a Japanese University Hospital, 2012-2015. (2018)
  • Author(s): Miura Y, Yamaguchi T, Nakamura I, Koyama S, Tamai K, Okanda T, Matsumoto T.
  • Journal Title: Microb Drug Resist. Volume: 24 Issue: 1 Pages: 70-75
  • DOI: 10.1089/mdr.2017.0008
  • Peer Reviewed
• [Journal Article] Peripheral venous catheter-related bloodstream infection is associated with severe complications and potential death: a retrospective observational study. (2017)
  • Author(s): Sato A, Nakamura I, Fujita H, Tsukimori A, Kobayashi T, Fukushima S, Fujii T, Matsumoto T.
  • Journal Title: BMC Infect Dis. Volume: 17 Issue: 1 Pages: 434-439
  • DOI: 10.1186/s12879-017-2536-0
  • Peer Reviewed / Open Access
• [Journal Article] Serotype distribution and antimicrobial susceptibility of Streptococcus pneumoniae strains isolated in Japan after introduction of the routine immunization program. (2017)
  • Author(s): Miyazaki H, Shibuya R, Midorikawa N, Chang B, Ohnishi M, Matsumoto T.
  • Journal Title: J Infect Chemother Volume: 23 Issue: 4 Pages: 234-240
  • DOI: 10.1016/j.jiac.2016.12.016
  • Peer Reviewed
• [Journal Article] Fatal sepsis caused by multidrug-resistant Bacteroides fragilis, harboring a cfiA gene and an upstream insertion sequence element, (2017)
  • Author(s): Nakamura I, Aoki K, Miura Y, Yamaguchi T, Matsumoto T.
  • Journal Title: Anaerobe Volume: 44 Pages: 36-39
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Number of Bacteria and Time of Coincubation With Bacteria Required for the Development of Acanthamoeba Keratitis. (2017)
  • Author(s): Nakagawa H, Hattori T, Koike N, Ehara T, Narimatsu A, Kumakura S, Matsumoto T, Goto H.
  • Journal Title: Cornea Volume: 36 Issue: 3 Pages: 353-357
  • DOI: 10.1097/ico.0000000000001129
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Evaluation of the rapid influenza detection tests GOLD SIGN FLU and Quick Navi-Flu for the detection of influenza A and B virus antigens in adults during the influenza season. (2016)
  • Author(s): Akaishi Y, Matsumoto T, Harada Y, Hirayama Y.
  • Journal Title: Int J Infect Dis Volume: 52 Pages: 55-58
  • DOI: 10.1016/j.ijid.2016.10.002
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Evolution and single-nucleotide polymorphisms in methicillin-resistant Staphylococcus aureus strains with reduced susceptibility to vancomycin and daptomycin, based on determination of the complete genome. (2015)
  • Author(s): Yamaguchi T, Suzuki S, Okamura S, Miura Y, Tsukimori A, Nakamura I, Ito N, Masuya A, Shiina T, Matsumoto T.
  • Journal Title: Antimicrob Agents Chemother. Volume: 59 Issue: 6 Pages: 3585-3587
  • DOI: 10.1128/aac.05159-14
  • Peer Reviewed
• [Journal Article] Combination Therapy against Polymicrobial Infection, Including by NDM-1-Producing Enterobacteriaceae Resistant to Colistin. (2015)
  • Author(s): Nakamura I, Sakamoto N, Ida Y, Imai R, Aoki K, Ando R, Yamaguchi T, Matsumura H, Matsumoto T. Combination
  • Journal Title: Antimicrob Agents Chemother. Volume: 59 Issue: 8 Pages: 5092-5093
  • DOI: 10.1128/aac.00746-15
  • Peer Reviewed
• [Presentation] プロバイオティクス菌株のin vitroにおける緑膿菌抑制効果 (2017)
  • Author(s): 松本哲哉, 宮崎治子, 大神田敬
  • Organizer: 第91回日本感染症学会総会
• [Presentation] revalence of resistant bacteria in ex- and in-hospital environments in Bangladesh (2017)
  • Author(s): Anwarul Haque, 江原友子, 大神田敬, 宮崎治子, 松本哲哉
  • Organizer: 第91回日本感染症学会総会
• [Presentation] MRSAに対するリゾホスファチジルコリンの作用とバンコマイシンとの併用効果 (2017)
  • Author(s): 三好菜摘, 宮崎治子, 江原友子, 松本哲哉
  • Organizer: MRSAフォーラム2017
• [Presentation] 肺炎球菌に類似した性状を示すStreptococcus属の検査学的・臨床的検討 (2017)
  • Author(s): 渋谷理恵, 宮崎治子, 大楠清文, 松本哲哉
  • Organizer: 第91回日本感染症学会総会
• [Presentation] ワクチン非含有血清型の肺炎球菌臨床分離株における病原性についての検討 (2017)
  • Author(s): 宮崎治子, 渋谷理恵, 常彬, 松本哲哉
  • Organizer: 第91回日本感染症学会総会
• [Presentation] Multi Drug Resistant Bacteria in Environment in Dhaka, Bangladesh (2016)
  • Author(s): Anwarul Haque，江原友子，高橋 涼，大楠清文，松本哲哉
  • Organizer: 第90回日本感染症学会総会・学術講演会
  • Place of Presentation: 仙台国際センター
• [Presentation] 肺炎球菌ワクチン導入後の臨床分離肺炎球菌における疫学的検討 (2016)
  • Author(s): 宮崎治子，渋谷理恵，小栗豊子，松本哲哉
  • Organizer: 第90回日本感染症学会総会・学術講演会
  • Place of Presentation: 仙台国際センター
• [Presentation] Resistant Bacteria in Environment in Dhaka, Bangladesh (2015)
  • Author(s): Anwarul H , Ehara T , Ohkusu K , Matsumoto T.
  • Organizer: 55th Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC)
  • Place of Presentation: San Diego (USA)
  • Year and Date: 2015-09-19
  • Int'l Joint Research
• [Presentation] Molecular diagnosis of extrapulmonary mycobacterial infections (2015)
  • Author(s): 1.Ohkusu K , Ezaki T, Matsumoto T.
  • Organizer: 25th ECCMID
  • Place of Presentation: Copenhagen (Denmark)
  • Year and Date: 2015-04-25
  • Int'l Joint Research
• [Book] 臨床微生物学 (2017)
  • Author(s): 松本哲哉、他
  • Total Pages: 421
  • Publisher: 医歯薬出版
• [Book] 内科学 第11版 (2017)
  • Author(s): 松本哲哉、他
  • Total Pages: 2385
  • Publisher: 朝倉書店
• [Book] 新呼吸器専門医テキスト (2015)
  • Author(s): 松本哲哉
  • Total Pages: 598
  • Publisher: 南江堂
• [Remarks] 東京医科大学微生物学講座
• [Remarks] 東京医科大学微生物学分野
  • URL: http://www.tokyo-med.ac.jp/microbiology/
• [Remarks] 東京医科大学微生物学講座
  • URL: http://www.tokyo-med.ac.jp/microbiology/index.html