| Project/Area Number |
15K09588
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Osaka Medical College |
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Principal Investigator |
Takahide Ito 大阪医科大学, 医学部, 講師 (00319550)
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| Co-Investigator(Kenkyū-buntansha) |
石坂 信和 大阪医科大学, 医学部, 教授 (20270879)
浮村 聡 大阪医科大学, 医学部, 教授 (50257862)
寺崎 文生 大阪医科大学, 医学部, 教授 (20236988)
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| Research Collaborator |
KANZAKI Yumiko 大阪医科大学, 医学部, 講師 (80445999)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | influenza / cardiac function / electrocardiogram / echocardiogram / cardiac enzymes / インフルエンザ心筋炎 / 心機能障害 / 左室拡張障害 / 心電図異常 / インフルエンザ感染症 / 心筋炎 / 心電図 / 心エコー / 心筋障害 / インフルエンザ / 前向き研究 |
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| Outline of Final Research Achievements |
Although life-threatening cardiac complications are rare in influenza infection, subclinical influenza-associated cardiac abnormalities may occur more frequently. A total of 102 subjects underwent a first set of examinations, including electrocardiography (ECG), echocardiography, and the measurement of cardiac enzyme levels. Those with one or more abnormal findings among these examinations were encouraged to undergo a repeat examination 2 weeks later. Among the 102 subjects, 20 (19.6%) were judged to have cardiac findings, those including ST-T abnormalities, pericardial effusion, diastolic dysfunction, and cardiac enzyme elevation. Eighteen of these 20 subjects underwent a second screening, and 11 of the 18 subjects were found free from cardiac findings. In conclusion the cardiac findings after influenza infection were only mild and transient; however, physicians should be aware of influenza infection-associated cardiac abnormalities because such abnormalities may not be rare.
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