Identification of reactivation factors for human herpes viruses

• Project/Area Number: 15K09591
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Infectious disease medicine
• Research Institution: National Cancer Center Japan
• Principal Investigator: SEO SACHIKO 国立研究開発法人国立がん研究センター, 東病院, 医長 (60401121)
• Co-Investigator(Kenkyū-buntansha): 塚崎 邦弘 埼玉医科大学, 造血器腫瘍科, 准教授 (40274659)
• Co-Investigator(Renkei-kenkyūsha): TSUCHIHARA KATSUYA 国立がん研究センター, 先端医療開発センター, 分野長 (00415514) ; TACHIKAWA AI 国立感染症研究所, エイズ研究センター, 室長 (10396880)
• Research Collaborator: MORI YUKI 虎の門病院, 血液内科, 医長 ; CHIBA SHIGERU 筑波大学付属病院, 血液内科, 教授 ; KANDA YOSHINOBU 自治医大さいたま医療センター, 血液科, 教授 ; AOTSUKA NOBUYUKI 成田赤十字病院, 血液腫瘍科, 部長 ; SAKAIDA EMIKO 千葉大学, 医学部付属病院・血液内科, 教授 ; ONODA MASAHIRO 千葉市立青葉病院, 血液内科, 部長
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: ヘルペスウィルス / 再活性化 / 造血幹細胞移植 / サイトメガロウィルス / HHV-6 / サイトカイン / 日和見感染症 / ウィルス再活性化

Outline of Final Research Achievements

In order to identify reactivation factors for human herpes viruses, we compared cytokine levels in hematopoietic cell transplant recipients with or without reactivation of human cytomegalovirus or human herpes virus-6. In results, we found that the levels of ST2(Stimulation 2) and LYVE1 (Lymphocyte vessel endothelial receptor1）have significantly changed at cytomegalovirus reactivation.

Research Products

• [Journal Article] Human rhinovirus detection in the lower respiratory tract of hematopoietic cell transplant recipients: association with mortality (2017)
  • Author(s): Seo S, Waghmare A, Scott EM, Xie H, Kuypers JM, Hackman RC, Campbell AP, Choi SM, Leisenring WM, Jerome KR, Englund JA, Boeckh M
  • Journal Title: Haematologica Volume: 印刷中 Issue: 6 Pages: 1120-1130
  • DOI: 10.3324/haematol.2016.153767
  • Peer Reviewed / Open Access
• [Journal Article] Herpes Zoster in Autologous Hematopoietic Cell Transplant Recipients in the Era of Acyclovir or Valacyclovir Prophylaxis and Novel Treatment and Maintenance Therapies (2017)
  • Author(s): Sahoo F, Hill JA, Xie H, Leisenring W, Yi J, Goyal S, Kimball LE, Lee I, Seo S, et al.
  • Journal Title: Biology of Blood and Marrow Transplantation Volume: 23 Issue: 3 Pages: 505-511
  • DOI: 10.1016/j.bbmt.2016.12.620
  • Peer Reviewed / Open Access
• [Journal Article] Bronchoalveolar Lavage DNA Quantification in Cytomegalovirus Pneumonia after Hematopoietic Cell Transplantation (2017)
  • Author(s): Boeckh M, Stevens-Ayers T, Travi G, Huang ML, Cheng GS, Xie H, Leisenring W, Erard V, Seo S, et al.
  • Journal Title: Bronchoalveolar Lavage DNA Quantification in Cytomegalovirus Pneumonia after Hematopoietic Cell Transplantation Volume: 印刷中 Issue: 10 Pages: 1514-1522
  • DOI: 10.1093/infdis/jix048
  • Peer Reviewed / Open Access
• [Journal Article] Clinical significance of human coronavirus in bronchoalveloar lavage samples from hematopoietic cell transplantation recipients and patients with hematologic malignancies (2017)
  • Author(s): Ogimi C, Waghmare AA, Kuypers JM, Xie H, Yeung CC, Leisenring WM, Seo S, et al.
  • Journal Title: Clinical Infectious Diseases Volume: 印刷中 Issue: 11 Pages: 1532-1539
  • DOI: 10.1093/cid/cix160
  • Peer Reviewed / Open Access
• [Journal Article] Impact of low-dose TBI on outcomes of reduced intensity conditioning allogeneic hematopoietic stem cell transplantation for AML (2016)
  • Author(s): Aoki J, Seo S, Kanamori H, Tanaka M, Fukuda T, Onizuka M, Kobayashi N, Kondo T, Sawa M, Uchida N, Iwato K, Ichinohe T, Atsuta Y, Yano S, Takami A
  • Journal Title: Bone Marrow Transplantation Volume: 51 Issue: 4 Pages: 604-606
  • DOI: 10.1038/bmt.2015.297
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] GVHD after HLA-matched sibling BMT or PBSCT: Comparison of North American Caucasian and Japanese populations (2016)
  • Author(s): Kanda J, Brazauskas R, Hu Z, Kuwatsuka Y, Nagafuji K, Kanamori H, Kanda Y, Miyamura K, Murata M, Fukuda T, Sakamaki H, Kimura F, Seo S, Aljurf M, Yoshimi A, Milone G, Wood WA, Ustun C, Hashimi S, Pasquini M, Bonfim C, Dalal J, Hahn T, Atsuta Y, Saber W
  • Journal Title: Biol Blood Marrow Transplant Volume: 22 Issue: 4 Pages: 744-751
  • DOI: 10.1016/j.bbmt.2015.12.027
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The incidence, mortality and timing of Pnuemocystis jiroveci pneumonia after hematopoietic cell transplantation: a CIBMTR analysis (2016)
  • Author(s): Williams KM, Ahn KW, Chen M, Aljurf MD, Agwu AL, Chen AR, Walsh TJ, Szabolcs P, Boeckh MJ, Auletta JJ, Lindemans CA, Zanis-Neto J, Malvezzi M, , Lister J, de Toledo Codina JS, Sackey K, Chakrabarty JL, Ljungman P, Wingard JR, Seftel MD, Seo S, et al.
  • Journal Title: Bone Marrow Transplantation Volume: 51 Issue: 4 Pages: 573-580
  • DOI: 10.1038/bmt.2015.316
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Human metapneumovirus infections following hematopoietic cell transplantation: Factors associated with disease progression (2016)
  • Author(s): Seo S, Gooley TA, Kuypers JM, Stednick Z, Jerome KR, Englund JA, Boeckh M
  • Journal Title: Clinical Infectious Diseases Volume: 62 Issue: 2 Pages: 178-185
  • DOI: 10.1093/cid/ciw284
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Incidentally-detected t(9;22)(q34;q11)/BCR-ABL1- positive clone developing into chronic phase chronic myeloid leukaemia after four years of dormancy (2016)
  • Author(s): Morita K, Nakamura F, Taoka K, Satoh Y, Iizuka H, Masuda A, Seo S, Nannya Y, Yatomi Y, Kurokawa M
  • Journal Title: British Journal of Haematology Volume: 173 Issue: 5 Pages: 815-817
  • DOI: 10.1111/bjh.13804
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Allogeneic transplantation provides durable remission in a subset of DLBCL patients relapsing after autologous transplantation (2016)
  • Author(s): Fenske T, Ahn KW, Graff TM, DiGilio A, Bashir Q, Kamble RT, Ayala R, Bacher U, Brammer JE, Cairo M, Chen A, Chen YB, Chhabara S, D’Souza A, Farooq U, Freytes C, Ganguly S, Hertzberg M, Inwards D, Jaglowski S, Kharfan-Dabaja MA, Lazarus HM, Nathan S, Pawarode A, Perales MA, Reddy N, Seo S, et al.
  • Journal Title: British Journal of Haematology Volume: 173 Issue: 2 Pages: 235-248
  • DOI: 10.1111/bjh.14046
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Reduced Mortality of Cytomegalovirus Pneumonia After Hematopoietic Cell Transplantation Due to Antiviral Therapy and Changes in Transplantation Practices (2015)
  • Author(s): Erard V, Guthrie KA, Seo S, Smith J, Huang M, Chien J, Flowers ME, Corey L, Boeckh M
  • Journal Title: Clinical Infectious Diseases Volume: 61 Issue: 1 Pages: 31-39
  • DOI: 10.1093/cid/civ215
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Idiopathic pneumonia syndrome after hematopoietic cell transplantation:evidence of occult infectious etiologies (2015)
  • Author(s): Seo S, Renaud C, Kuypers JM, Chiu CY, Huang ML, Samayoa E, Xie H, Yu G, Fisher CE, Gooley TA, Miller S, Hackman RC, Myerson D, Sedlak RH, Kim YJ, Fukuda T, Fredricks DN, Madtes DK, Jerome KR, Boeckh M
  • Journal Title: Blood Volume: 125 Issue: 24 Pages: 3789-3797
  • DOI: 10.1182/blood-2014-12-617035
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Contribution of chemotherapy mobilization to disease control in multiple myeloma treated with autologous hematopoietic cell transplantation (2015)
  • Author(s): Uy GL, Costa LJ, Hari PN, Zhang MJ, Huang JX, Anderson KC, Bredeson CN, Callander NS, Cornell RF, Perez MA, Dispenzieri A, Freytes CO, Gale RP, Garfall A, Gertz MA, Gibson J, Hamadani M, Lazarus HM, Kalaycio ME, Kamble RT, Kharfan-Dabaja MA, Krishnan AY, Kumar SK, Kyle RA, Landau HJ, Lee CH, Maiolino A, et al.
  • Journal Title: Bone Marrow Transplantation Volume: 50 Issue: 12 Pages: 1513-1518
  • DOI: 10.1038/bmt.2015.190
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Biomarkers for idiopathic pneumonia syndrome after hematopoietic cell transplantation : Predictors for occurrence and survival (2017)
  • Author(s): Seo S, Yu J, Jenkins IC, Leisenring WM, Stevens-Ayers TL, Kuypers JM, Huang M, Jerome KR, Boeckh M, Paczesny S
  • Organizer: The 43rd Annual Meeting of the European Society for Blood and Marrow Transplantation
  • Place of Presentation: Marseille, France
  • Year and Date: 2017-03-26
  • Int'l Joint Research
• [Presentation] Microbiome of the lung in patient with idiopathic pneumonia syndrome (IPS) after HCT (2017)
  • Author(s): Seo S, Tamburini F, Hill J, Duke F, Stevens-Ayers T, Jerome KR, Bhatt A, Boeckh M
  • Organizer: 2017 BMT tandem meetings
  • Place of Presentation: Florida, USA
  • Year and Date: 2017-02-22
  • Int'l Joint Research
• [Presentation] Respiratory virus infections in hematopoietic cell transplant recipients (2016)
  • Author(s): 瀬尾 幸子
  • Organizer: 日本血液学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-13
  • Invited
• [Presentation] 血液腫瘍内科における薬-薬連携 (2016)
  • Author(s): 小室雅人、望月伸夫、瀬尾幸子、松井礼子、成川研介、塚崎邦弘、齊藤真一郎
  • Organizer: 第4回日本臨床腫瘍薬学会学術集会
  • Place of Presentation: 鹿児島
  • Year and Date: 2016-03-12
• [Presentation] 非血縁者間骨髄移植におけるドナー年齢の影響: JSHCTワーキンググループ研究 (2016)
  • Author(s): 瀬尾幸子、諫田淳也、熱田由子、内田直之、大橋一輝、福田隆浩、高橋聡、小澤幸泰、鬼塚真仁、高梨美乃子、塚田信弘、加藤俊一、木村文彦、神田善伸、宮村耕一
  • Organizer: 第38回日本造血幹細胞移植学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2016-03-03
• [Presentation] Biomarkers for idiopathic pneumonia syndrome (IPS) after hematopoietic cell transplantation (HCT): Comparison with viral infectious pneumonia (2016)
  • Author(s): Seo S, Yu J, Jenkins IC, Stevens-Ayers TL, Kuypers JM, Huang M, Leisenring WM, Jerome KR, Boeckh M, Paczesny S
  • Organizer: 2016 BMT tandem meetings
  • Place of Presentation: Ｈａｗａｉｉ， Ｕ．Ｓ．Ａ．
  • Year and Date: 2016-02-18
  • Int'l Joint Research
• [Presentation] The impact of donor age on outcome after unrelated bone marrow transplantation: comparison with unrelated cord blood transplantation (2015)
  • Author(s): Seo S, Kanda J, Atsuta Y, Uchida N, Ohashi K, Fukuda T, Takahashi S, Ozawa Y, Onizuka M, Takanashi M, Tsukada N, Kato S, Kimura F, Kanda Y, Miyamura K
  • Organizer: The 57th Annual Meeting of American Society of Hematology
  • Place of Presentation: Ｏｒｌａｎｄ， Ｕ．Ｓ．Ａ．
  • Year and Date: 2015-12-05
  • Int'l Joint Research
• [Presentation] Outcome of gastric diffuse large B-cell lymphoma and usefulness of PET-CT in detecting gastric lesion (2015)
  • Author(s): Kadota T, Seo S, Nakagami Y, Fuse H, Ueda Y, Ishii G, Ito K, Yano T, Kaneko K, Tsukasaki K
  • Organizer: The 57th Annual Meeting of American Society of Hematology
  • Place of Presentation: Ｏｒｌａｎｄ， Ｕ．Ｓ．Ａ．
  • Year and Date: 2015-12-05
  • Int'l Joint Research
• [Presentation] Human metapneumovirus infections in hematopoietic cell transplant recipients: Seasonality and factors associated with progression to lower respiratory tract disease (2015)
  • Author(s): Seo S, Gooley TA, Kuypers JM, Stednick Z, Jerome KR, Englund JA, Boeckh M
  • Organizer: The 20th Congress of APBMT
  • Place of Presentation: 沖縄
  • Year and Date: 2015-10-30
  • Int'l Joint Research
• [Presentation] 胃びまん性大細胞型B細胞リンパ腫の予後と胃病変診断におけるPETの有用性 (2015)
  • Author(s): 門田智裕、瀬尾幸子、 中神佳宏、布施弘恵、 小濵知佐、石井源一郎、 岡村直香、伊藤國明、 根津雅彦、矢野友規、塚崎邦弘
  • Organizer: 第53回日本癌治療学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2015-10-29
• [Presentation] 単施設におけるMethotrexate関連リンパ増殖性疾患(MTX-associated lymphoproliferative disorders)19例と薬剤師の役割 (2015)
  • Author(s): 山口亜由美、松井礼子、岡村直香、瀬尾幸子、根津雅彦、伊藤國明、石井源一郎、斎藤真一郎、塚崎邦弘.
  • Organizer: 第13回日本臨床腫瘍学会学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2015-07-16
• [Presentation] ステロイド単独療法で寛解したMTX中止抵抗性のMTX関連リンパ増殖性疾患の1例 (2015)
  • Author(s): 岡村直香、山口亜由美、松井礼子、瀬尾幸子、根津雅彦、斎藤真一郎、伊藤國明、田丸淳一、石井源一郎、塚崎邦弘
  • Organizer: 第55回リンパ網内系学会総会
  • Place of Presentation: 岡山
  • Year and Date: 2015-07-09
• [Book] Thomas’ Hematopoietic Cell Transplantation The 5th edition (2016)
  • Author(s): Seo S, Boeckh M
  • Total Pages: 1416
  • Publisher: Wiley-Blackwell