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Molecular mechanism for maintenance of mature synapse - to elucidate the regression phenomenon of Rett syndrome -

Research Project

Project/Area Number 15K09602
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionTokyo Women's Medical University

Principal Investigator

Yagasaki Yuki  東京女子医科大学, 医学部, 助教 (90392422)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords脳・神経 / 神経疾患 / レット症候群 / MeCP2 / 成熟シナプスの維持機構 / 脳・神経、神経疾患 / mGluR1 / 脳・神経、脳神経疾患
Outline of Final Research Achievements

Retinogeniculate (RG) synapses in the mouse dorsal lateral geniculate nucleus (dLGN) are known to develop into the mature circuit through three phases: synapse formation (P0-P10), synapse elimination (P10-P20), and the experience-dependent maintenance (P20-30) phases. Methyl CpG binding protein 2 (MeCP2), a transcriptional regulator associated with Rett syndrome, has been reported to be involved in experience-dependent maintenance of RG synapses. The MeCP2 expression pattern in the mouse dLGN, however, is not fully understood during the three phases. We found that the MeCP2 protein level in the dLGN gradually increased in glutamatergic but not GABAergic neurons during development. Interestingly, dark rearing from P21 for 10 days decreased MeCP2 expression only in glutamatergic neurons in the dLGN. These results suggest that the MeCP2 expression level in glutamatergic neurons is regulated in a visual experience-dependent manner during the RG synapse maintenance phase.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2017 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (5 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Afferent fiber remodeling in the somatosensory thalamus of mice as a neural basis of somatotopic reorganization in the brain and ectopic mechanical hypersensitivity after peripheral sensory nerve injury2017

    • Author(s)
      Yuichi Takeuchi,Hironobu Osaki,Yuki Yagasaki,Yoko Katayama,Mariko Miyata
    • Journal Title

      eNeuro

      Volume: 4 Issue: 2 Pages: ENEURO.0345-16.2017

    • DOI

      10.1523/eneuro.0345-16.2017

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Metabotropic Glutamate Receptor Subtype 1 Mediates Experience-Dependent Maintenance of Mature Synaptic Connectivity in the Visual Thalamus2016

    • Author(s)
      Madoka Narushima, Motokazu Uchigashima, Yuki Yagasaki, Takeshi Harada, Yasuyuki Nagumo, Naofumi Uesaka, Kouichi Hashimoto, Atsu Aiba, Masahiko Watanabe, Mariko Miyata and Masanobu Kano
    • Journal Title

      Neuron

      Volume: 91 Issue: 5 Pages: 1097

    • DOI

      10.1016/j.neuron.2016.07.035

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 発達期マウス外側膝状体におけるMeCP2タンパク質の発現制御機構2017

    • Author(s)
      矢ヶ崎 有希、 三好 悟一、宮田 麻理子
    • Organizer
      第94回 日本生理学会
    • Place of Presentation
      アクトシティ浜松(静岡県浜松市)
    • Related Report
      2016 Research-status Report
  • [Presentation] 神経発達症因子 FoxG1によるGABA抑制性回路の発達機構2016

    • Author(s)
      三好 悟一、植田 禎史、尾崎 弘展 、矢ヶ崎 有希、花嶋 かりな 、Gord Fishell、 宮田 麻理子
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2016-03-23
    • Related Report
      2015 Research-status Report
  • [Presentation] 1型代謝型グルタミン酸受容体による網膜-外側膝状体シナプスの成熟型結合パタンの維持2016

    • Author(s)
      鳴島 円、内ヶ島 基政 、矢ヶ崎 有希 、原田 武志、南雲 康 、上阪 直史、渡邉 貴樹、 橋本 浩一、饗場 篤、渡辺 雅彦、宮田 麻理子、狩野 方伸
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
  • [Presentation] Type I metabotropic glutamate receptor is crucial for visual experience-dependent maintenance of mature connectivity of retinogeniculate synapses2016

    • Author(s)
      Madoka Narushima, Motokazu Uchigashima, Yuki Yagasaki, Takeshi Harada, Yasuyuki Nagumo, Naofumi Uesaka, Kouichi Hashimoto, Atsu Aiba, Masahiko Watanabe, Mariko Miyata, Masanobu Kano
    • Organizer
      10th FENS Forum of Neuroscience
    • Place of Presentation
      Copenhagen, Denmark
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 網膜―視床外側膝状体シナプス維持期におけるMeCP2タンパク質の発現制御2015

    • Author(s)
      矢ヶ崎 有希、 宮田 麻理子
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場・神戸国際展示場
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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