| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Outline of Final Research Achievements |
In this study, we aimed to clarify epigenetic mechanisms in development of the testicular supporting cells, Sertoli cells.
Peptidylarginine deiminases (PADs) are a family of enzymes that change the charge of target proteins through citrullination. We identified Padi2 which encodes PAD2 was exclusively expressed in Sertoli cells of fetal developing testes. Our data suggested that Padi2 was a novel gene in fetal testis development which was specifically expressed in Sertoli cells through the regulation of SOX9 and FOXL2 and supported regulation by SOX9 for target genes. The phenotype of Padi2(-/-)XY indicates that a redundant factor compensates for the role of PAD2 in testicular development.
|
