| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Intraperitoneal pentylenetetrazole injection elicited seizures of variable severity in the polymicrogyria rats (PMG). Neuron degeneration and reactive axonal elongation were significantly and widely distributed in the interneurons of PMG, suggesting that the relatively selective vulnerability of inhibitory interneurons constitutes the basis for the decreased seizure threshold observed in this model of polymicrogyria. In the clinical investigations of patients with severe motor and intellectual disabilities (SMID), an electroencephalogram analysis revealed that multifocal spike discharge was more frequently detected in the profound SMID group than in the non-profound SMID group. Multifocal epileptogenesis was thought to be one of the most characteristic findings in SMID patients, which may be closely associated with a factor involved in the intractability of epilepsy in these patients.
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