Investigation for pathogenesity of "osteolysis" in multcentric carpotarsal osteolysis
Project/Area Number |
15K09623
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | Okayama University |
Principal Investigator |
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Research Collaborator |
HIGUCHI Yousuke
YAMASHITA Miho
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 骨形成 / 骨吸収 / 骨芽細胞 / 軟骨細胞 |
Outline of Final Research Achievements |
We conducted functional analysis of Wild and mutant (T62P and R63G) in MC3T3E1 and ATDC5. Overexpression of wild MafB induced apoptosis in MC3T3E1. In ATDC5, we analyzed runx2 mRNA expression before confluent state and after confluent state and we observed different runx2 mRNA expression according to the differentiation stage (Before confluent state, wild=T62P>R63G; after confluent state, runx2 R63G>T52P>wild).
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Neonatal-Onset Hereditary Coproporphyria: A New Variant of Hereditary Coproporphyria.2017
Author(s)
Hasegawa K, Tanaka H, Yamashita M, Higuchi Y, Miyai T, Yoshimoto J, Okada A, Suzuki N, Iwatsuki K, Tsukahara H.
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Journal Title
JIMD Rep.
Volume: 印刷中
Pages: 99-106
DOI
ISBN
9783662563588, 9783662563595
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Vitamin D resistance in hypovitaminosis D2015
Author(s)
Hiroyuki Tanaka, Moe Takatsuka, Chika Okahara, Yoshie Noguchi, Kazuo Ogura, Tsutomu Takata, Kosei Hasegawa
Organizer
The 11th Asian Society For Pediatric Research
Place of Presentation
Osaka
Year and Date
2015-04-15
Related Report
Int'l Joint Research
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