Prediction of DiabetesMellitus by using with iPS cell technology
| Project/Area Number |
15K09625
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kumamoto University |
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Principal Investigator |
MATSUMOTO SHIROU 熊本大学, 大学院生命科学研究部(医), 准教授 (70467992)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAMURA KIMITOSHI 熊本大学, 大学院生命科学研究部小児科学分野, 教授 (30336234)
KIDO JUN 熊本大学, 医学部附属病院小児科学分野, 特任助教 (70721215)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 小児糖尿病 / iPS細胞 / エネルギー代謝 / 1型糖尿病 / β細胞 / 再生医療 / バイオマーカー / 糖尿病 / 細胞内代謝機能 / メタボローム解析 |
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| Outline of Final Research Achievements |
We tried to establish for prediction of DiabetesMellitus by using with iPS cell technology and novel therapeutic strategy with stem cells. We could isolated iPS cells originated from healthy control and type 1 Diabetes Mellitus, which were differentiated into beta cells. We could establish the way to purify the insulin producing cells and expansion methods with these iPS cells. We could also establish the method of mass culture suitable to clinical therapy. In addition, we analyzed metabolome investigation in beta cells differentiated from iPS cells and it is indicated that mitochondrial dysfunction may influence type 1 diabetes.
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Report
(4 results)
Research Products
(8 results)
