| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Outline of Final Research Achievements |
Genomic analysis studies on patients with developmental disorders have led the synaptic dysfunction to be considered the essence of the disorder. However, it is almost always that synaptic pathology is suspected from genomic information, and the actual state of molecular pathology at the cell level is hardly understood yet. Therefore, we analyzed the pathological condition at the level of neurons differentiated from human iPS cells and attempted to clarify the molecular dysfunction and its pathology. As a result, it was shown that gene knockdown reduces spine density in neuronal dendrites. We are planning to investigate whether this phenomenon can be rescued by drug administration in the future.
|
