Elucidation of immunological pathophysiology of non-herpetic acute limbic encephalitis: IgG subclass-complement dependent disorder
Project/Area Number |
15K09634
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders |
Principal Investigator |
Takahashi Yukitoshi 独立行政法人国立病院機構(静岡・てんかん神経医療センター臨床研究部), その他部局等, その他 (70262764)
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Research Collaborator |
NISHIMURA Shigeko
TAKAO Emiko
KASAI Risa
ENOKIDA Kaoru
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | 非ヘルペス性急性辺縁系脳炎 / 免疫病態 / GluN2B抗体 / GluN1抗体 / IgGサブクラス / 活性化補体 / 免疫複合体 / 補体 |
Outline of Final Research Achievements |
Results: Before immunomodulation therapy (IT), mean level of C5a of NHALE was higher than that of DCs (p=0.0271), and 36.8% of patients had higher levels than mean+2SD of DCs. Evolution of C5a suggested peak level around 10 days after onsets. Before IT, mean level of iC3b in NHALE was higher than that of DCs(p<0.0001), and 66.7% of patients had higher levels than mean+2SD of DCs. Evolution of iC3b suggested peak level around 10 days after onsets. Before IT, mean level of MAC in NHALE was higher than that of DCs (p<0.0001), and 51.4% of patients had higher levels than mean+2SD of DCs. The mean level in NHALE was also higher (p=0.0003) after IT. Before & after IT, mean level of CD59 was not different between two groups. Conclusion: In approximately half of NHALE patients, increased activated complements may contribute to the impairment of neuronal cells in acute stage.
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Report
(4 results)
Research Products
(76 results)
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[Journal Article] Prospective HLA-A*31:01 screening and the incidence of carbamazepine-induced cutaneous adverse reactions in Japanese.2018
Author(s)
Mushiroda T, Takahashi Y, Onuma T, Yamamoto Y, Kamei T, Hoshida T, Takeuchi K, Otsuka K, Okazaki M, Watanabe M, Kanemoto K, Oshima T, Watanabe A, Minami S, Saito K, Tanii H et al; GENCAT Study Group.
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Journal Title
JAMA Neurology
Volume: 75
Issue: 7
Pages: 842-849
DOI
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Peer Reviewed
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[Journal Article] Kikuchi-Fujimoto disease (histiocytic necrotizing lymphadenitis) with atypical encephalitis and painful testitis: a case report,2017
Author(s)
Hidenori Kido, Osamu Kano, Asami Hamai, Hiroyuki Masuda, Yutaka Fuchinoue, Masaaki Nemoto, Chiaki Arai, Teppei Takeda, Fumihito Yamabe, Toshihiro Tai, Mizuki Kasahara, Kenichi Suzuki, Nobuyuki Shiraga, Sota Sadamoto, Megumi Wakayama, Yukitoshi Takahashi, Yasuo Iwasaki, Kazutoshi Shibuya, Yoshihisa Urita
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Journal Title
BMC Neurology
Volume: 17
Pages: 22-22
Related Report
Peer Reviewed
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[Journal Article] A case of early onset epileptic encephalopathy with de novo mutation in SLC35A2: Clinical features and treatment for epilepsy2017
Author(s)
Kimizu T, Takahashi Y, Oboshi T, Horino A, Koike T, Yoshitomi S, Mori T, Yamaguchi T, Ikeda H, Okamoto N, Nakashima M, Saitsu H, Kato M, Matsumoto N, Imai K
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Journal Title
Brain & Development
Volume: 39
Pages: 256-260
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Peer Reviewed
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[Journal Article] Anti-N-methyl-D-aspartate receptor antibodies are associated with fibromyalgia in patients with systemic lupus erythematosus: a case-control study2017
Author(s)
.Shin-Seok Lee, D. Park, Y. Takahashi, J. Kang, Y. Yim, J. Kim, J. Lee, K. Lee, J. Lee, S. Lee,
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Journal Title
Clinical and Experimental Rheumatology
Volume: 35 S105
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Peer Reviewed / Int'l Joint Research
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[Journal Article] TuberOus SClerosis registry to increase disease Awareness (TOSCA) baseline data on 2093 patients2017
Author(s)
John C Kingswood, Maria Dahlin, Petrus J de Vries, Martha Feucht, Carla Fladrowski, Gabriella Gislimberti, Christoph Hertzberg, Sergiusz Jozwiak, John A Lawson, Alfons Macaya, Rima Nabbout, Finbar O’Callaghan, Mirjana P Benedik, Jiong Qin, Marques Ruben, Valentin Sander, Matthias Sauter, Yukitoshi Takahashi, et al.,
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Journal Title
Orphanet Journal of Rare Diseases
Volume: 12
Pages: 2-2
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Peer Reviewed / Int'l Joint Research
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[Journal Article] Ovarian Teratoma Development after Anti-NMDA Receptor Encephalitis Treatment2017
Author(s)
Taku Omata, Kazuo Kodama, Yoshimi Watanabe, Yukiko Iida, Yoshiaki Furusawa, Akiko Takashima, Yukitoshi Takahashi, Hiroshi Sakuma, Keiko Tanaka, Katsunori Fujii, and Naoki Shimojo
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Journal Title
Brain & Development
Volume: 39
Pages: 448-451
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Peer Reviewed
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[Journal Article] Kikuchi-Fujimoto disease (histiocytic necrotizing lymphadenitis) with atypical encephalitis and painful testitis: a case report2017
Author(s)
10.Hidenori Kido, Osamu Kano, Asami Hamai, Hiroyuki Masuda, Yutaka Fuchinoue, Masaaki Nemoto, Chiaki Arai, Teppei Takeda, Fumihito Yamabe, Toshihiro Tai, Mizuki Kasahara, Kenichi Suzuki, Nobuyuki Shiraga, Sota Sadamoto, Megumi Wakayama, Yukitoshi Takahashi, Yasuo Iwasaki, Kazutoshi Shibuya, Yoshihisa Urita
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Related Report
Peer Reviewed
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[Journal Article] Antibodies against peptides of NMDA-type GluR in cerebrospinal fluid of patients with epileptic spasms2016
Author(s)
4.Tatsuo Mori, Yukitoshi Takahashi, Nami Araya, Taikan Oboshi, Hirokazu Watanabe, Kazuki Tsukamoto, Tokito Yamaguchi, Shinsaku Yoshitomi, Hirosato Nasu, Hiroko Ikeda, Hideyuki Otani, Katsumi Imai, Hideo Shigematsu, Yushi Inoue
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Journal Title
European Journal of Paediatric Neurology
Volume: 20
Pages: 865-873
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Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Factors that influence the pharmacokinetics of lamotrigine in Japanese patients with epilepsy2016
Author(s)
6.Kazuyuki Inoue, Yoshiaki Yamamoto, Eri Suzuki, Toshiki Takahashi, Akiko Umemura, Yukitoshi Takahashi, Katsumi Imai, Yushi Inoue, Keita Hirai, Daiki Tsuji, Kunihiko Itoh
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Journal Title
Eur J Clin Pharmacol
Volume: 72
Pages: 555-562
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Peer Reviewed
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[Journal Article] Acute encephalitis with refractory, repetitive partial seizures: Pathological findings and a new therapeutic approach using tacrolimus2016
Author(s)
8.Yuko Sato, Yurika Numata-Uematsu, Mitsugu Uematsu, Atsuo Kikuchi, Tojo Nakayama, Yosuke Kakisaka, Tomoko Kobayashi, Naomi Hino-Fukuyo, Hiroyoshi Suzuki, Yukitoshi Takahashi, Yoshiaki Saito, Naoyuki Tanuma, Masaharu Hayashi, Masaki Iwasaki, Kazuhiro Haginoya, Shigeo Kure
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Journal Title
Brain & Development
Volume: 38
Pages: 772-776
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Peer Reviewed
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[Journal Article] Effects of donepezil and serotonin re-uptake inhibitor on acute regression during adolescence in Down syndrome2016
Author(s)
Akiko Tamasaki, Yoshiaki Saito, Riyo Ueda, Koyo Ohno, Katsutoshi Yokoyama, Takahiro Satake, Hiroshi Sakuma, Yukitoshi Takahashi, Tatsuro Kondoh, Yoshihiro Maegaki,
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Journal Title
Brain & Development
Volume: 38
Pages: 113-117
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Peer Reviewed
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[Journal Article] Immediate suppression of seizure clusters by corticosteroids in PCDH19 female epilepsy2015
Author(s)
Norimichi Higurashi, Yukitoshi Takahashi, Ayako Kashimada, Yuji Sugawara, Hiroshi Sakuma, Yuko Tomono, Takahito Inoue, Megumi Hoshina, Ruri Satomi, Masaharu Ohfu, Kazuya Itomi, Kyoko Takano, Tomoko Kirino, Shinichi Hirose,
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Journal Title
Seizure
Volume: 27
Pages: 1-5
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Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Semi-quantitative analyses of antibodies to N-methyl-D-aspartate type glutamate receptor subunits (GluN2B & GluN1) in the clinical course of Rasmussen syndrome2015
Author(s)
Tetsuhiro Fukuyama, Yukitoshi Takahashi, Yuko Kubota, Yukiko Mogami, Katsumi Imai, Yoshiyuki Kondo, Hiroshi Sakuma, Koji Tominaga, Hirokazu Oguni, Shigeko Nishimura.
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Journal Title
Epilepsy Research,
Volume: 113
Pages: 34-43
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Peer Reviewed / Acknowledgement Compliant
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[Journal Article] CSF cytokine profile distinguishes multifocal motor neuropathy from progressive muscular atrophy.2015
Author(s)
Takahiro Furukawa, Naoko Matsui, Koji Fujita, Hiroyuki Nodera, Fumitaka Shimizu, Katsuichi Miyamoto, Yukitoshi Takahashi, Takashi Kanda, Susumu Kusunoki, Yuishin Izumi, Ryuji Kaji,
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Journal Title
Neurol Neuroimmunol Neuroinflamm
Volume: 2
Issue: 5
DOI
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Peer Reviewed
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[Journal Article] Three patients manifesting early infantile epileptic spasms associated with 2q24.3 microduplications2015
Author(s)
Shinsaku Yoshitomi, Yukitoshi Takahashi, Mamiko Hotate Ishizuka, Tokito Yamaguchi, Akito Watanabe, Hirosato Nasu, Yuki Ueda, Hideyuki Ohtani, Hiroko Ikeda, Katsumi Imai, Hideo Shigematsu, Yushi Inoue, Yoshihiro Tanahashi, Kaori Aiba, Hodaka Ohta, Shino Shimada, Toshiyuki Yamamoto,
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Journal Title
Brain & Development
Volume: 37
Pages: 874-879
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Brain FDG-PET reflecting clinical course of depression induced by systemic lupus erhythematosus: two case reports2015
Author(s)
Tomoyuki Saito, Maasa Hama, Yuhei Chiba, Omi Katsuse, Ayuko Kamada, Takahiro Ikura, Kaoru Minegishi, Atsushi Ihata, Yukitoshi Takahashi, Yoshiaki Ishigatsubo, Yoshio Hirayasu
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Journal Title
Journal of the Neurological Scences
Volume: 358
Pages: 464-466
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Peer Reviewed
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[Presentation] West syndrome NHO-Japan 342 ACTH cases study: Developmental outcome of the initial ACTH therapy2016
Author(s)
18.Yukitoshi Takahashi, Akiko Oota, Yushi Inoue, Jun Tohyama, Hiroshi Fujita, Nishizato Chizuru, Jyunya Takahashi, Shigeki Tanaka, Nagao Masayoshi, Shiraga Hiroshi, Hideo Kaneko, Yasuko Sawai,
Organizer
第58回日本小児神経学会
Place of Presentation
東京
Year and Date
2016-06-02
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